Difference between revisions of "25I-NBOH"
From DMT-Nexus Wiki
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* 25I-NBOH is a very new substance, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known. | * 25I-NBOH is a very new substance, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known. | ||
* Elaborate studies on this substance have not been performed, so long term effects are UNKNOWN! | * Elaborate studies on this substance have not been performed, so long term effects are UNKNOWN! | ||
| − | * Warning: This chemical is active in the '''microgram | + | * Warning: This chemical is active in the '''[https://en.wikipedia.org/wiki/Microgram microgram (µg)] range'''! Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are VITAL! '''Please start with doses of 500µg or less!''' |
| − | * Warning: Do not ingest 25I-NBOH while under the influence of a second medicine/substance/drug/MAOI! | + | * Warning: Do not ingest 25I-NBOH while '''under the influence of a second medicine/substance/drug/MAOI!''' |
* Warning: Do not ingest 25I-NBOH when your mental or physical health is poor. '''Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting]!''' | * Warning: Do not ingest 25I-NBOH when your mental or physical health is poor. '''Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting]!''' | ||
}} | }} | ||
| − | '''25I-NBOH''' (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen [https://en.wikipedia.org/wiki/2C-I 2C-I]. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, '''making it some twelve times the potency of 2C-I itself'''. In contrast to '''[[25x-NBOME|25I-NBOMe]]''' with a Ki of 0.044 nM ('''sixteen times the potency of 2C-I''').<ref>wikipedia.org: [https://en.wikipedia.org/wiki/25I-NBOH 25I-NBOH]</ref><ref>wikipedia.org: [https://en.wikipedia.org/wiki/25I-NBOMe 25I-NBOMe]</ref> Therefore treat | + | '''25I-NBOH''' (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen [https://en.wikipedia.org/wiki/2C-I 2C-I]. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, '''making it some twelve times the potency of 2C-I itself'''. In contrast to '''[[25x-NBOME|25I-NBOMe]]''' with a Ki of 0.044 nM ('''sixteen times the potency of 2C-I''').<ref>wikipedia.org: [https://en.wikipedia.org/wiki/25I-NBOH 25I-NBOH]</ref><ref>wikipedia.org: [https://en.wikipedia.org/wiki/25I-NBOMe 25I-NBOMe]</ref> Therefore treat 25I-NBOH like you would treat 25I-NBOMe. |
It was discovered in 2006 by a team at Purdue University. | It was discovered in 2006 by a team at Purdue University. | ||
| − | *Activity via '''[https://en.wikipedia.org/wiki/Sublingual_administration sublingual administration]''' or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses! | + | *Activity via '''[https://en.wikipedia.org/wiki/Sublingual_administration sublingual administration]''' or parenteral starts at well below one milligram (full activity at 500-700µg) and '''<span style="color:#FF2020">may be fatal in high doses</span>'''! |
*Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined. | *Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined. | ||
Revision as of 14:26, 19 April 2014
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25I-NBOH (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen 2C-I. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, making it some twelve times the potency of 2C-I itself. In contrast to 25I-NBOMe with a Ki of 0.044 nM (sixteen times the potency of 2C-I).[1][2] Therefore treat 25I-NBOH like you would treat 25I-NBOMe.
It was discovered in 2006 by a team at Purdue University.
- Activity via sublingual administration or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses!
- Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined.
Links
- bluelight.org: The Big Dandy 25I-NBOH Thread
- isomerdesign.com: 25I-NBOH
- wikipedia.org: 25I-NBOH
- eve-rave.ch: 25i/c-nboh (German)
- drugs-forum.com: 25I-NBOH Experiences
