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  • Psychedelic
Main effects:
  • Open and closed eye visuals, euphoria, change in perception of time
Side effects:
  • Nausea (possible), vasoconstriction, unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing (possible), enlarged pupils
Health risks:
  • paranoia (possible), fear (possible), panic (possible), dystonia (rare), seizure (rare), death (rare)
Important safety remarks:
  • 25I-NBOH is a very new substance, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known.
  • Elaborate studies on this substance have not been performed, so long term effects are UNKNOWN!
  • Warning: This chemical is active in the microgram (µg) range! Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are VITAL! Please start with doses of 500µg or less!
  • Warning: Do not ingest 25I-NBOH while under the influence of a second medicine/substance/drug/MAOI!
  • Warning: Do not ingest 25I-NBOH when your mental or physical health is poor. Observe the set and setting!

25I-NBOH (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen 2C-I. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, making it some twelve times the potency of 2C-I itself. In contrast to 25I-NBOMe with a Ki of 0.044 nM (sixteen times the potency of 2C-I).[1][2] Therefore treat 25I-NBOH like you would treat 25I-NBOMe.

It was discovered in 2006 by a team at Purdue University.

  • Activity via sublingual administration or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses!
  • Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined.



  1. wikipedia.org: 25I-NBOH
  2. wikipedia.org: 25I-NBOMe