Difference between revisions of "25I-NBOH"
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* Open and closed eye visuals, euphoria, change in perception of time | * Open and closed eye visuals, euphoria, change in perception of time | ||
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| − | * Nausea (possible), [ | + | * Nausea (possible), [https://en.wikipedia.org/wiki/Vasoconstriction vasoconstriction], unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing (possible), enlarged pupils |
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| − | * paranoia (possible), fear (possible), panic (possible), [ | + | * paranoia (possible), fear (possible), panic (possible), [https://en.wikipedia.org/wiki/Dystonia dystonia] (rare), seizure (rare), death (rare) |
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* 25I-NBOH is a very new substance, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known. | * 25I-NBOH is a very new substance, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known. | ||
* Elaborate studies on this substance have not been performed, so long term effects are UNKNOWN! | * Elaborate studies on this substance have not been performed, so long term effects are UNKNOWN! | ||
| − | * Warning: This chemical is active in the '''microgram | + | * Warning: This chemical is active in the '''[https://en.wikipedia.org/wiki/Microgram microgram (µg)] range'''! Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are VITAL! '''Please start with doses of 500µg or less!''' |
| − | * Do not ingest 25I-NBOH while under the influence of a second medicine/substance/drug/MAOI! | + | * Warning: Do not ingest 25I-NBOH while '''under the influence of a second medicine/substance/drug/MAOI!''' |
| + | * Warning: Do not ingest 25I-NBOH when your mental or physical health is poor. '''Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting]!''' | ||
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| − | '''25I-NBOH''' (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen [ | + | '''25I-NBOH''' (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen [https://en.wikipedia.org/wiki/2C-I 2C-I]. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, '''making it some twelve times the potency of 2C-I itself'''. In contrast to '''[[25x-NBOME|25I-NBOMe]]''' with a Ki of 0.044 nM ('''sixteen times the potency of 2C-I''').<ref>wikipedia.org: [https://en.wikipedia.org/wiki/25I-NBOH 25I-NBOH]</ref><ref>wikipedia.org: [https://en.wikipedia.org/wiki/25I-NBOMe 25I-NBOMe]</ref> Therefore treat 25I-NBOH like you would treat 25I-NBOMe. |
It was discovered in 2006 by a team at Purdue University. | It was discovered in 2006 by a team at Purdue University. | ||
| − | *Activity via sublingual or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses | + | *Activity via '''[https://en.wikipedia.org/wiki/Sublingual_administration sublingual administration]''' or parenteral starts at well below one milligram (full activity at 500-700µg) and '''<span style="color:#FF2020">may be fatal in high doses</span>'''! |
*Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined. | *Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined. | ||
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==Links== | ==Links== | ||
* bluelight.org: [http://www.bluelight.org/vb/threads/663416-The-Big-Dandy-25I-NBOH-Thread The Big Dandy 25I-NBOH Thread] | * bluelight.org: [http://www.bluelight.org/vb/threads/663416-The-Big-Dandy-25I-NBOH-Thread The Big Dandy 25I-NBOH Thread] | ||
| + | * drugs-forum.com: [http://www.drugs-forum.com/forum/showthread.php?t=95632 25I-NBOH Experiences] | ||
* isomerdesign.com: [http://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=5379 25I-NBOH] | * isomerdesign.com: [http://isomerdesign.com/PiHKAL/explore.php?domain=pk&id=5379 25I-NBOH] | ||
* wikipedia.org: [https://en.wikipedia.org/wiki/25I-NBOH 25I-NBOH] | * wikipedia.org: [https://en.wikipedia.org/wiki/25I-NBOH 25I-NBOH] | ||
* eve-rave.ch: [http://eve-rave.ch/Forum/viewtopic.php?f=53&t=32464 25i/c-nboh] (German) | * eve-rave.ch: [http://eve-rave.ch/Forum/viewtopic.php?f=53&t=32464 25i/c-nboh] (German) | ||
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== Reference == | == Reference == | ||
Latest revision as of 14:26, 19 April 2014
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25I-NBOH (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen 2C-I. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, making it some twelve times the potency of 2C-I itself. In contrast to 25I-NBOMe with a Ki of 0.044 nM (sixteen times the potency of 2C-I).[1][2] Therefore treat 25I-NBOH like you would treat 25I-NBOMe.
It was discovered in 2006 by a team at Purdue University.
- Activity via sublingual administration or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses!
- Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined.
Links
- bluelight.org: The Big Dandy 25I-NBOH Thread
- drugs-forum.com: 25I-NBOH Experiences
- isomerdesign.com: 25I-NBOH
- wikipedia.org: 25I-NBOH
- eve-rave.ch: 25i/c-nboh (German)
