Difference between revisions of "25I-NBOH"
From DMT-Nexus Wiki
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* Open and closed eye visuals, euphoria, change in perception of time | * Open and closed eye visuals, euphoria, change in perception of time | ||
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| − | * Nausea (possible), [ | + | * Nausea (possible), [https://en.wikipedia.org/wiki/Vasoconstriction vasoconstriction], unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing (possible), enlarged pupils |
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| − | * paranoia (possible), fear (possible), panic (possible), [ | + | * paranoia (possible), fear (possible), panic (possible), [https://en.wikipedia.org/wiki/Dystonia dystonia] (rare), seizure (rare), death (rare) |
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* 25I-NBOH is a very new substance, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known. | * 25I-NBOH is a very new substance, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known. | ||
* Elaborate studies on this substance have not been performed, so long term effects are UNKNOWN! | * Elaborate studies on this substance have not been performed, so long term effects are UNKNOWN! | ||
* Warning: This chemical is active in the '''microgram''' (µg) range! Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are VITAL! '''Please start with doses of 500µg or less!''' | * Warning: This chemical is active in the '''microgram''' (µg) range! Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are VITAL! '''Please start with doses of 500µg or less!''' | ||
| − | * Do not ingest 25I-NBOH while under the influence of a second medicine/substance/drug/MAOI! | + | * Warning: Do not ingest 25I-NBOH while under the influence of a second medicine/substance/drug/MAOI! |
| − | * Do not ingest 25I-NBOH when your mental or physical health is poor. '''Observe the [ | + | * Warning: Do not ingest 25I-NBOH when your mental or physical health is poor. '''Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting]!''' |
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| − | '''25I-NBOH''' (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen [ | + | '''25I-NBOH''' (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen [https://en.wikipedia.org/wiki/2C-I 2C-I]. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, '''making it some twelve times the potency of 2C-I itself'''. In contrast to '''[[25x-NBOME|25I-NBOMe]]''' with a Ki of 0.044 nM ('''sixteen times the potency of 2C-I''').<ref>wikipedia.org: [https://en.wikipedia.org/wiki/25I-NBOH 25I-NBOH]</ref><ref>wikipedia.org: [https://en.wikipedia.org/wiki/25I-NBOMe 25I-NBOMe]</ref> Therefore treat the NBOH series substances like the NBOMe series substances. |
It was discovered in 2006 by a team at Purdue University. | It was discovered in 2006 by a team at Purdue University. | ||
| − | *Activity via sublingual or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses | + | *Activity via '''[https://en.wikipedia.org/wiki/Sublingual_administration sublingual administration]''' or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses! |
*Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined. | *Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined. | ||
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==Links== | ==Links== | ||
Revision as of 14:17, 19 April 2014
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25I-NBOH (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen 2C-I. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, making it some twelve times the potency of 2C-I itself. In contrast to 25I-NBOMe with a Ki of 0.044 nM (sixteen times the potency of 2C-I).[1][2] Therefore treat the NBOH series substances like the NBOMe series substances.
It was discovered in 2006 by a team at Purdue University.
- Activity via sublingual administration or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses!
- Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined.
Links
- bluelight.org: The Big Dandy 25I-NBOH Thread
- isomerdesign.com: 25I-NBOH
- wikipedia.org: 25I-NBOH
- eve-rave.ch: 25i/c-nboh (German)
- drugs-forum.com: 25I-NBOH Experiences
