Other ergolines

Other ergolines

the ergot molecuul is pretty fragile and decomposes easy in some Water/light/(some)air , the 3 best spots to change/improve the coumpound is at the most stable parts...those are the Nitrogens..in the moleculair ergot structur you see 3"N"'s , these are the nitrogens, one is at the bottom (position 1) , nr 2 is in the mid right position called position nr 6 and the third one is near the top connected to position 8 ( the positions are the number yuo get wen you srt counting the connection on the outside of the molecule anti clockwise , try it !. people have actually tried to change the "N's possitions through extenting these nitrogen the ergoline compounds lsd follow the same principle, but here are some lesser know other samples :

1)on the 8 position :

- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1-4 mg. it still unknown if these can cause gangreen / nercosis in certain people. source (J.ott in Pharmacotheon )

-(S)Lasba : a stereoselective butyl analoog on the 8-amide has been found active in humans a few years ago, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience) nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url]

-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)

on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.

promising : - future research is being done to replace the carboxylic acid to a "thoiacid" this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide. Warnig : activity and safeties of these compounds are still unknown.

- non-psychoactive ergolines : bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more, these are now used as proper migrane- an other-medicine.

- and then there is the sub-family called the clavines who mostly have only 2 nitrogens in their structures which seems to have less medicinal properties and is sleightly less stabiel, therefor the main rearch woldwide is focused on the ergot-family.