Other ergolines

Other ergolines

1)on the 8 position :

- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg. it still unknown if these can cause gangreen / nercosis in certain people. source (J.ott in Pharmacotheon )

-(S)Lasba : a stereoseective butyl analoog on the 8-amide has been found active in humans, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience) nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url]

-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)

on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.

promising : - future research is being done to replace the carboxylic acid to a "thoiacid" this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide. Warnig : activity and safeties of these compounds are still unknown.

- non-psychoactive ergolines : bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more, these are now used as proper migrane- an other-medicine.

- and then there is the sub-family called the clavines, but the main rearch focus is on the ergots.