Difference between revisions of "Other ergolines"

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(Other ergolines)
(Other ergolines)
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== Other ergolines ==
 
== Other ergolines ==
  
on the 8 position :
+
1)on the 8 position :
  
- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg.
+
- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg. it still unknown if these can cause gangreen / nercosis in certain people.
 
source (J.ott in Pharmacotheon )
 
source (J.ott in Pharmacotheon )
(it still unknown if these can cause gangreen / nercosis in certain people..)
 
  
-(s)Lasba : a(stereoseective butyl analoog on the 8-amide) has been found active in humans, but mostly act as a stimulant (perdue uni/nichols/personal exprience)
+
 
nice info to be found here : [http://bitnest.ca/Silo42/10.1007/BF02245940.pdf]
+
-(S)Lasba : a stereoseective butyl analoog on the 8-amide has been found active in humans, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience)
 +
nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url]
 +
 
  
 
-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)
 
-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)
 +
 +
 +
on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.
 +
  
 
promising :
 
promising :
- future research is being done to replace the carboxylic acid to a "thoiacid" (actually a thioeaster)
+
- future research is being done to replace the carboxylic acid to a "thoiacid"  
this means at the top the oxygen will be repaced with a sulphur(=thio) and then still have room for the   N-diethyl amide. (activity of these compound are still unknown.)
+
this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide.  
 +
Warnig : activity and safeties of these compounds are still unknown.
 +
 
  
 
- non-psychoactive ergolines :
 
- non-psychoactive ergolines :
  bromocryptine, dihydroergotamine , dihydrolysergic, carbagoline and a bunch more , now used as proper migrane- an other-medicine.
+
bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more,  
 +
these are now used as proper migrane- an other-medicine.
  
on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.
+
 
 +
- and then there is the sub-family called the clavines, but the main rearch focus is on the ergots.

Revision as of 13:33, 11 March 2014

Other ergolines

1)on the 8 position :

- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg. it still unknown if these can cause gangreen / nercosis in certain people. source (J.ott in Pharmacotheon )


-(S)Lasba : a stereoseective butyl analoog on the 8-amide has been found active in humans, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience) nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url]


-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)


on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.


promising : - future research is being done to replace the carboxylic acid to a "thoiacid" this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide. Warnig : activity and safeties of these compounds are still unknown.


- non-psychoactive ergolines : bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more, these are now used as proper migrane- an other-medicine.


- and then there is the sub-family called the clavines, but the main rearch focus is on the ergots.