25I-NBOH

Safety profile
Category: Psychedelic
Main effects: Open and closed eye visuals, euphoria, change in perception of time
Side effects: Nausea (possible), vasoconstriction(mostly when combined with other vasoconstricting substances like LSD), unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing (possible), enlarged pupils
Health risks: paranoia (possible), fear (possible), panic (possible), dystonia (rare), seizure (rare), death (rare)
Important safety remarks: 25I-NBOH is a very new substance, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known. Elaborate studies on this substance have not been performed, so long term effects are UNKNOWN! Warning: This chemical is active in the microgram (µg) range! Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are VITAL! Please start with doses of 500µg or less! Do not ingest 25I-NBOH while under the influence of a second medicine/substance/drug/MAOI!

25I-NBOH (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen 2C-I. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, making it some twelve times the potency of 2C-I itself. In contrast to 25I-NBOMe with a Ki of 0.044 nM, sixteen times the potency of 2C-I.

It was discovered in 2006 by a team at Purdue University.

• Activity via sublingual or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses.

• Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined.

• Doses above one-two milligram(s) have produced profound effects including severe confusion, disorientation, and overwhelming visual distortions.

• Doses of more than three milligrams may produce seizures and doses of less than ten milligrams may be fatal (shown in other n-benzyl derivatives).

Links

• bluelight.org: The Big Dandy 25I-NBOH Thread
• isomerdesign.com: 25I-NBOH
• wikipedia.org: 25I-NBOH
• eve-rave.ch: 25i/c-nboh (German)
• drugs-forum.com: 25I-NBOH Experiences