Other ergolines

Other ergolines

on the 8 position :

- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg. source (J.ott in Pharmacotheon )

(it still unknown if these can cause gangreen / nercosis in certain people..)

-(s)Lasba : a(stereoseective butyl analoog on the 8-amide) has been found active in humans, but mostly act as a stimulant (perdue uni/nichols/personal exprience) nice info to be found here : [1]

-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)

promising : - future research is being done to replace the carboxylic acid to a "thoiacid" (actually a thioeaster)

this means at the top the oxygen will be repaced with a sulphur(=thio) and then still have room for the   N-diethyl amide. (activity of these compound are still unknown.)

- non-psychoactive ergolines :

 bromocryptine, dihydroergotamine , dihydrolysergic, carbagoline and a bunch more , now used as proper migrane- an other-medicine.

on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.