Dissociative

What is it?

Dissociatives are a class of hallucinogen, which distort perceptions of sight and sound and produce feelings of detachment - dissociation - from the environment and self. This is done through reducing or blocking signals to the conscious mind from other parts of the brain. Although many kinds of drugs are capable of such action, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include sensory deprivation, dissociation, hallucinations, and dream-like states or trances. Some, which are nonselective in action and affect the dopamine and/or opioid systems, may be capable of inducing euphoria. Many dissociatives have general depressant effects and can produce sedation, respiratory depression[citation needed], analgesia, anesthesia, and ataxia, as well as cognitive and memory impairment and amnesia.

The primary area of activation for dissociatives is blockade of the Ca++ ion in the NDMA receptor. Also known as uncompetitive NMDA receptor antagonists.

Noncompetitive antagonists result in the same effect on the receptor, but achieve it in a slightly different way.

See images D & E

Dissociatives can also be classified by molecular structure. The most well known dissociatives used recreationally and in medicine are known as arylcyclohexylamines

Another well known dissociative Dextromethorphan (DXM) has a very opioid like structure. It is classified as a morphinan

NMDA receptor antagonists

Safety profile
Category: NMDA receptor antagonists
Main effects: Dissociation, Anesthesia, Analgesia(neuropathic pain), Euphoria, immersive out of body experiences (The Hole), auditory hallucinations
Side effects: Raised blood pressure (Hypertension), loss of motor coordination (Ataxia), Confusion and disorientation, increase in heart rate, slurred speech
Health risks: Addiction (psychological dependency), delusions of grandeur, risk of accidental self-injury due to analgesic effects (high doses), chronic exposure [<5g per day] causes urinary tract and bladder damage (ketamine)
Important safety remarks: Dissociatives can seem like they are too good to be true in comparison with serotogenic hallucinogens because they ARE! They carry serious longterm mental and physical risks with their usage.

Adamantanes

Amantadine

Memantine

Rimantadine

Arylcyclohexylamines

Dieticyclidine

Esketamine

Eticyclidine

Gacyclidine

Ketamine

Metaphit

Methoxetamine (MXE)

Neramexane

Phencyclidine (PCP)

Phenylhexylcyclopyrrolidine

Rolicyclidine

Tenocyclidine

Tiletamine

Methoxydine (4-MeO-PCP)

Morphinans

Dextromethorphan

Dextrorphan

Methorphan

Morphanol

Others

2-MDP

8A-PDHQ

Aptiganel

Dexoxadrol

Diethyl ether

Dizocilpine

Etoxadrol

Midafotel

NEFA

Nitrous oxide

Noribogaine

Perzinfotel

Remacemide

Selfotel

Xenon

κ-opioid agonists

kappa-opioid agonists are an entirely different type of drug that can have dissociative effects. κ-opioid wikipedia page

Very little is known about this receptor and its effects on the body. Evidence points towards dynorphin, the endogenous κ-opioid agonist, to play a major role in substance addiction.

Safety profile
Category: κ-opioid receptor agonists
Main effects: Dissociation, Dysphoria (occasional euphoria), immersive out of body experiences, strong visual and auditory hallucinations, potential to aid addiction recovery
Side effects: Strange, uncomfortable body sensations (physical pressures), loss of motor coordination (Ataxia), Confusion and disorientation, increase in heart rate, temporary paralysis, extreme fear
Health risks: Risk of accidental self-injury due to intense dissociation (deleriant effects), (READ DANGEROUS OF Ibogaine)
Important safety remarks: Ibogaine has some serious health risks and should be researched further before dosing.

2-EMSB

2-MMSB

Alazocine

Bremazocine

Butorphanol

Cyclazocine

Cyprenorphine

Dezocine

Enadoline

Herkinorin

HZ-2

Ibogaine

Ketazocine

Metazocine

Nalbuphine

Nalfurafine

Nalorphine

Noribogaine

Phenazocine

Pentazocine

Salvinorin A

Spiradoline

Tifluadom

U-50488