What is it?
Dissociatives are a class of hallucinogen, which distort perceptions of sight and sound and produce feelings of detachment - dissociation - from the environment and self. This is done through reducing or blocking signals to the conscious mind from other parts of the brain. Although many kinds of drugs are capable of such action, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include sensory deprivation, dissociation, hallucinations, and dream-like states or trances. Some, which are nonselective in action and affect the dopamine and/or opioid systems, may be capable of inducing euphoria. Many dissociatives have general depressant effects and can produce sedation, respiratory depression, analgesia, anesthesia, and ataxia, as well as cognitive and memory impairment and amnesia.
The primary area of activation for dissociatives is blockade of the Ca++ ion in the NDMA receptor. Also known as uncompetitive NMDA receptor antagonists.
Noncompetitive antagonists result in the same effect on the receptor, but achieve it in a slightly different way.
Another well known dissociative Dextromethorphan (DXM) has a very opioid like structure. It is classified as a morphinan
NMDA receptor antagonists
kappa-opioid agonists are an entirely different type of drug that can have dissociative effects. κ-opioid wikipedia page
Very little is known about this receptor and its effects on the body. Evidence points towards dynorphin, the endogenous κ-opioid agonist, to play a major role in substance addiction.
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