Difference between revisions of "25I-NBOH"
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* Warning: This chemical is active in the '''microgram''' (µg) range! Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are VITAL! '''Please start with doses of 500µg or less!''' | * Warning: This chemical is active in the '''microgram''' (µg) range! Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are VITAL! '''Please start with doses of 500µg or less!''' | ||
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| − | '''25I-NBOH''' (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen [[2C-I]]. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor | + | '''25I-NBOH''' (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen [[2C-I]]. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, '''making it some twelve times the potency of 2C-I itself'''. In contrast to 25I-NBOMe with a Ki of 0.044 nM, sixteen times the potency of 2C-I.<ref>wikipedia.org: [https://en.wikipedia.org/wiki/25I-NBOH 25I-NBOH]</ref><ref>wikipedia.org: [https://en.wikipedia.org/wiki/25I-NBOMe 25I-NBOMe]</ref> |
It was discovered in 2006 by a team at Purdue University. | It was discovered in 2006 by a team at Purdue University. | ||
Revision as of 13:58, 19 April 2014
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25I-NBOH (NBOH-2CI, Cimbi-27) is a derivative of the phenethylamine derived hallucinogen 2C-I. It acts as a potent agonist for the 5HT2A receptor, with a Ki of 0.061nM at the human 5HT2A receptor, making it some twelve times the potency of 2C-I itself. In contrast to 25I-NBOMe with a Ki of 0.044 nM, sixteen times the potency of 2C-I.[1][2]
It was discovered in 2006 by a team at Purdue University.
- Activity via sublingual or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses.
- Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined.
- Doses above one-two milligram(s) have produced profound effects including severe confusion, disorientation, and overwhelming visual distortions.
- Doses of more than three milligrams may produce seizures and doses of less than ten milligrams may be fatal (shown in other n-benzyl derivatives).
Links
- bluelight.org: The Big Dandy 25I-NBOH Thread
- isomerdesign.com: 25I-NBOH
- wikipedia.org: 25I-NBOH
- eve-rave.ch: 25i/c-nboh (German)
- drugs-forum.com: 25I-NBOH Experiences
