Difference between revisions of "Other ergolines"
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Revision as of 12:59, 11 March 2014
Other ergolines
1)on the 8 position :
- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg. it still unknown if these can cause gangreen / nercosis in certain people. source (J.ott in Pharmacotheon )
-(S)Lasba : a stereoseective butyl analoog on the 8-amide has been found active in humans, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience)
nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url]
-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)
on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.
promising :
- future research is being done to replace the carboxylic acid to a "thoiacid"
this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide.
Warnig : activity and safeties of these compounds are still unknown.
- non-psychoactive ergolines :
bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more,
these are now used as proper migrane- an other-medicine.
- and then there is the sub-family called the clavines, which sems to have less medicinal properties therefor the main rearch woldwide is focused on the ergot-family.
