Difference between revisions of "Other ergolines"
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== Other ergolines == | == Other ergolines == | ||
| − | on the 8 position : | + | 1)on the 8 position : |
| − | - some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg. | + | - some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg. it still unknown if these can cause gangreen / nercosis in certain people. |
source (J.ott in Pharmacotheon ) | source (J.ott in Pharmacotheon ) | ||
| − | |||
| − | -( | + | |
| − | nice info to be found here : [http://bitnest.ca/Silo42/10.1007/BF02245940.pdf] | + | -(S)Lasba : a stereoseective butyl analoog on the 8-amide has been found active in humans, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience) |
| + | nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url] | ||
| + | |||
-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.) | -also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.) | ||
| + | |||
| + | |||
| + | on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin. | ||
| + | |||
promising : | promising : | ||
| − | - future research is being done to replace the carboxylic acid to a "thoiacid" | + | - future research is being done to replace the carboxylic acid to a "thoiacid" |
| − | + | this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide. | |
| + | Warnig : activity and safeties of these compounds are still unknown. | ||
| + | |||
- non-psychoactive ergolines : | - non-psychoactive ergolines : | ||
| − | + | bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more, | |
| + | these are now used as proper migrane- an other-medicine. | ||
| − | + | ||
| + | - and then there is the sub-family called the clavines, but the main rearch focus is on the ergots. | ||
Revision as of 12:33, 11 March 2014
Other ergolines
1)on the 8 position :
- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg. it still unknown if these can cause gangreen / nercosis in certain people. source (J.ott in Pharmacotheon )
-(S)Lasba : a stereoseective butyl analoog on the 8-amide has been found active in humans, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience)
nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url]
-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)
on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.
promising :
- future research is being done to replace the carboxylic acid to a "thoiacid"
this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide.
Warnig : activity and safeties of these compounds are still unknown.
- non-psychoactive ergolines :
bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more,
these are now used as proper migrane- an other-medicine.
- and then there is the sub-family called the clavines, but the main rearch focus is on the ergots.
