Difference between revisions of "Dissociative"

Revision as of 22:32, 9 December 2012

What is it?

Dissociatives are a class of hallucinogen, which distort perceptions of sight and sound and produce feelings of detachment - dissociation - from the environment and self. This is done through reducing or blocking signals to the conscious mind from other parts of the brain. Although many kinds of drugs are capable of such action, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include sensory deprivation, dissociation, hallucinations, and dream-like states or trances. Some, which are nonselective in action and affect the dopamine and/or opioid systems, may be capable of inducing euphoria. Many dissociatives have general depressant effects and can produce sedation, respiratory depression[citation needed], analgesia, anesthesia, and ataxia, as well as cognitive and memory impairment and amnesia.

The primary area of activation for dissociatives is blockade of the Ca++ ion in the NDMA receptor. Also known as uncompetitive NMDA receptor antagonists.

Noncompetitive antagonists result in the same effect on the receptor, but achieve it in a slightly different way.

See images D & E

Dissociatives can also be classified by molecular structure. The most well known dissociatives used recreationally and in medicine are known as arylcyclohexylamines

Another well known dissociative Dextromethorphan (DXM) has a very opioid like structure. It is classified as a morphinan

NMDA receptor antagonists

Adamantanes

Amantadine

Memantine

Rimantadine

Arylcyclohexylamines

Dieticyclidine

Esketamine

Eticyclidine

Gacyclidine

Ketamine

Metaphit

Methoxetamine (MXE)

Neramexane

Phencyclidine (PCP)

Phenylhexylcyclopyrrolidine

Rolicyclidine

Tenocyclidine

Tiletamine

Methoxydine (4-MeO-PCP)

Morphinans

Dextromethorphan

Dextrorphan

Methorphan

Morphanol

Others

2-MDP

8A-PDHQ

Aptiganel

Dexoxadrol

Diethyl ether

Dizocilpine

Etoxadrol

Midafotel

NEFA

Nitrous oxide

Noribogaine

Perzinfotel

Remacemide

Selfotel

Xenon

κ-opioid agonists

kappa-opioid agonists are an entirely different type of drug that can have dissociative effects.

Very little is known about this receptor and its effects on the body.

2-EMSB 2-MMSB Alazocine Bremazocine Butorphanol Cyclazocine Cyprenorphine Dezocine Enadoline Herkinorin HZ-2 Ibogaine Iboga Ketazocine Metazocine Nalbuphine Nalfurafine Nalorphine Noribogaine Phenazocine Pentazocine Salvinorin A (found in Salvia divinorum)Salvia Spiradoline Tifluadom U-50488