Difference between revisions of "Tetrahydroharmine"

Revision as of 09:08, 12 February 2023

Brief overview - What is THH?

Tetrahydroharmine (THH) is a fluorescent pyschoactive indole alkaloid. It occurs naturally in B. Caapi. Like other harmala alkaloids it is a RIMA reversible inhibitor of monoamine oxidase A. However, unlike harmine and harmaline, THH also inhibits reuptake of serotonin.

Chemical and physical properties

Formula:C13H16N2O

Molar mass:216.284 g·mol−1

Solubility:

DMF: 1.5 mg/ml

PBS (pH 7.2): 0.25 mg/ml

DMSO: 2 mg/ml

Ethanol: 1.5 mg/ml

Ethyl Acetate: unknown mg/ml

Melting point: Unknown

Effects

Pharmacology, toxicity and general safety

Thought to be metabolized similarly to other harmala alkaloids. Toxicity thought to be similar to other harmala alkaloids i.e the LD50 of haamine is 243 mg/kg SC inmice models. Like other harmala alkaloids thought to be unsafe with certain drugs, could potentially cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant, stimulants, common migraine medication, certain herbs, most cold medicine, opiates, nicotine and caffeine.

Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity.

Plants containing THH

Conversion teks

THH_reduction

Future Research

Potential reduction pathways

Dosages and consumption methods

History of usage

Analysis of THH

GC-MS

https://www.dmt-nexus.me/forum/default.aspx?g=posts&m=189029#post189029

Scientific publications

Other links of interest