Difference between revisions of "Other ergolines"
(→Other ergolines) |
(→Other ergolines) |
||
| (4 intermediate revisions by one user not shown) | |||
| Line 1: | Line 1: | ||
== Other ergolines == | == Other ergolines == | ||
| − | + | the ergot molecuul is pretty fragile and decomposes easy in some moist/light/(some)air , the 3 best spots to change/improve the coumpound stabilitiet is reanforce at the most stable parts...those are the Nitrogens..in the moleculair ergot structur you see 3"N"'s , these are the nitrogens, one is at the bottom (position 1) , nr 2 is in the mid right position called position nr 6 and the third one is near the top connected to position 8 ( the positions are the number you get when you start counting the connections on the outside of the molecule anti-clockwise , try it !. | |
| + | people have tried to add more atoms /elements to the "N's possitions and one such experiment was hoffman 25th try for a new compound eventually known as lsd....but here are some lesser know other samples : | ||
| − | - some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg. | + | 1)on the 8 position : |
| + | |||
| + | - some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1-4 mg. it still unknown if these can cause gangreen / nercosis in certain people. | ||
source (J.ott in Pharmacotheon ) | source (J.ott in Pharmacotheon ) | ||
| − | |||
| − | -( | + | |
| − | nice info to be found here : [http://bitnest.ca/Silo42/10.1007/BF02245940.pdf] | + | -(S)Lasba : a stereoselective butyl analoog on the 8-amide has been found active in humans a few years ago, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience) |
| + | nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url] | ||
| + | |||
-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.) | -also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.) | ||
| + | |||
| + | |||
| + | on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin. | ||
| + | |||
promising : | promising : | ||
| − | - future research is being done to replace the carboxylic acid to a "thoiacid" | + | - future research is being done to replace the carboxylic acid to a "thoiacid" |
| − | + | this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide. | |
| + | Warnig : activity and safeties of these compounds are still unknown. | ||
| + | |||
- non-psychoactive ergolines : | - non-psychoactive ergolines : | ||
| − | + | bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more, | |
| + | these are now used as proper migrane- an other-medicine. | ||
| − | + | ||
| + | - and then there is the sub-family called the clavines who mostly have only 2 nitrogens in their structures which seems to have less medicinal properties and is sleightly less stabiel, therefor the main rearch woldwide is focused on the ergot-family. | ||
Latest revision as of 13:56, 11 March 2014
Other ergolines
the ergot molecuul is pretty fragile and decomposes easy in some moist/light/(some)air , the 3 best spots to change/improve the coumpound stabilitiet is reanforce at the most stable parts...those are the Nitrogens..in the moleculair ergot structur you see 3"N"'s , these are the nitrogens, one is at the bottom (position 1) , nr 2 is in the mid right position called position nr 6 and the third one is near the top connected to position 8 ( the positions are the number you get when you start counting the connections on the outside of the molecule anti-clockwise , try it !. people have tried to add more atoms /elements to the "N's possitions and one such experiment was hoffman 25th try for a new compound eventually known as lsd....but here are some lesser know other samples :
1)on the 8 position :
- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1-4 mg. it still unknown if these can cause gangreen / nercosis in certain people. source (J.ott in Pharmacotheon )
-(S)Lasba : a stereoselective butyl analoog on the 8-amide has been found active in humans a few years ago, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience)
nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url]
-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)
on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.
promising :
- future research is being done to replace the carboxylic acid to a "thoiacid"
this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide.
Warnig : activity and safeties of these compounds are still unknown.
- non-psychoactive ergolines :
bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more,
these are now used as proper migrane- an other-medicine.
- and then there is the sub-family called the clavines who mostly have only 2 nitrogens in their structures which seems to have less medicinal properties and is sleightly less stabiel, therefor the main rearch woldwide is focused on the ergot-family.
