Difference between revisions of "Gramine"

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== What is gramine ==
 
== What is gramine ==
  
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* Gramine is an indole alkaloid present in some plants such as from Phalaris and Arundo spp. It has been claimed to be potentially toxic, however recent evidence shows it to have very low toxicity (relative to other alkaloids such as tryptamines) and to have potential antimutagenic effects. It is found most commonly in Avena sativa (Oats).
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* Gramine is an indole alkaloid present in some plants such as Phalaris, Phargmites, and Arundo spp. While it has been previously feared by some to be potentially toxic, recent evidence shows it to have very low toxicity (relative to other alkaloids such as tryptamines) and to have potential antimutagenic effects. It is found most commonly in ''Avena sativa'' (Oats). <ref>''Safety evaluation of an oat grain alkaloid gramine by genotoxicity assays'', Manash Pratim Pathak et al. Drug Chem Toxicol. 2018 Apr. https://pubmed.ncbi.nlm.nih.gov/28523965/ </ref> <ref>https://forum.dmt-nexus.me/threads/phalaris-project.362215/post-3873447</ref>
  
 
== Chemical and physical properties ==
 
== Chemical and physical properties ==
  
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[Gramine properties http://wiki.dmt-nexus.me/Psychedelic_Compounds_Chemical_and_Physical_Properties#Gramine]
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Gramine (''3-(dimethylaminomethyl)-indole'') properties http://wiki.dmt-nexus.me/Psychedelic_Compounds_Chemical_and_Physical_Properties#Gramine]
  
 
== Extractions ==
 
== Extractions ==
  
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To eliminate gramine from extractions, so far there havent been many tested methods but potentially extracting with aliphatic naphtha/hexane/heptane/petroleum ether, and recrystallizing in one of these solvents should get rid of it considering Merck Index indicates it is not soluble in those solvents, as written in the chemical properties link above.
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Gramine is not soluble in naphtha or petroleum ether, therefore extractions using these solvents will not contain gramine. It is soluble in ethanol.
  
 
== Analysis ==
 
== Analysis ==
  
 
[https://www.dmt-nexus.me/forum/default.aspx?g=posts&m=295867#post295867 Gramine and other alkaloid's Rf for TLC and column chromatography]
 
[https://www.dmt-nexus.me/forum/default.aspx?g=posts&m=295867#post295867 Gramine and other alkaloid's Rf for TLC and column chromatography]
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== References ==
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<references/>

Latest revision as of 13:34, 3 November 2024

Graminefreebase.png

What is gramine

  • Gramine is an indole alkaloid present in some plants such as Phalaris, Phargmites, and Arundo spp. While it has been previously feared by some to be potentially toxic, recent evidence shows it to have very low toxicity (relative to other alkaloids such as tryptamines) and to have potential antimutagenic effects. It is found most commonly in Avena sativa (Oats). [1] [2]

Chemical and physical properties

Gramine (3-(dimethylaminomethyl)-indole) properties http://wiki.dmt-nexus.me/Psychedelic_Compounds_Chemical_and_Physical_Properties#Gramine]

Extractions

Gramine is not soluble in naphtha or petroleum ether, therefore extractions using these solvents will not contain gramine. It is soluble in ethanol.

Analysis

Gramine and other alkaloid's Rf for TLC and column chromatography

References

  1. ↑ Safety evaluation of an oat grain alkaloid gramine by genotoxicity assays, Manash Pratim Pathak et al. Drug Chem Toxicol. 2018 Apr. https://pubmed.ncbi.nlm.nih.gov/28523965/
  2. ↑ https://forum.dmt-nexus.me/threads/phalaris-project.362215/post-3873447
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