Gramine

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What is gramine

  • Gramine is an indole alkaloid present in some plants such as Phalaris, Phargmites, and Arundo spp. It has been previously claimed to be potentially toxic, however recent evidence shows it to have very low toxicity (relative to other alkaloids such as tryptamines) and to have potential antimutagenic effects. It is found most commonly in Avena sativa (Oats). [1] [2]

Chemical and physical properties

[Gramine (3-(dimethylaminomethyl)-indole) properties http://wiki.dmt-nexus.me/Psychedelic_Compounds_Chemical_and_Physical_Properties#Gramine]

Extractions

Gramine is not soluble in naphtha or petroleum ether, therefore extractions using these solvents will not contain gramine. It is soluble in ethanol.

Analysis

Gramine and other alkaloid's Rf for TLC and column chromatography

References

  1. Safety evaluation of an oat grain alkaloid gramine by genotoxicity assays, Manash Pratim Pathak et al. Drug Chem Toxicol. 2018 Apr. https://pubmed.ncbi.nlm.nih.gov/28523965/
  2. https://forum.dmt-nexus.me/threads/phalaris-project.362215/post-3873447