Difference between revisions of "1P-LSD"

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* Psychedelic
 
* Psychedelic
 
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* Open and closed eye visuals, euphoria, change in perception of time. Anecdotal report of being indistinguishable from LSD.
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* Anecdotal report of being indistinguishable from LSD.<ref>[http://www.bluelight.org/vb/threads/745848-The-Big-amp-Dandy-1P-LSD-%281-propionyl-lysergic-acid-diethylamide%29-Thread bluelight.org: The Big & Dandy 1P-LSD (1-propionyl-lysergic acid diethylamide) Thread]</ref>
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* Possible main effects: open and closed eye visuals, euphoria, change in perception of time.
 
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* Possible side effects: nausea, [https://en.wikipedia.org/wiki/Vasoconstriction vasoconstriction], unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing
 
* Possible side effects: nausea, [https://en.wikipedia.org/wiki/Vasoconstriction vasoconstriction], unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing
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* 1P-LSD is a research chemical not mentioned in academic literature. The LD50 (median lethal dose) or long term / pharmacological / behavioral risks are not known.  
 
* 1P-LSD is a research chemical not mentioned in academic literature. The LD50 (median lethal dose) or long term / pharmacological / behavioral risks are not known.  
 
* 1P-LSD is likely a controlled substance analogue under US law if intended for human consumption.
 
* 1P-LSD is likely a controlled substance analogue under US law if intended for human consumption.
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* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are vital.  
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* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use caution when working with this substance, a calibrated milligram scale and liquid measurement are vital.  
 
* Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}
 
* Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}
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== Chemical and physical properties ==
 
[[Image:1P-LSD.png|right|thumb|200px|1P-LSD]]
 
[[Image:1P-LSD.png|right|thumb|200px|1P-LSD]]
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== Brief overview - What is 1P-LSD? ==
 
 
* Systematic (IUPAC) name: (6aR,9R)-4-propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
 
* Systematic (IUPAC) name: (6aR,9R)-4-propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
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* Synonym: 1-Propionyl-lysergic acid diethylamide
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== Chemical and physical properties ==
 
 
From an old Wikipedia draft:<ref>https://en.wikipedia.org/w/index.php?title=Draft:1P-LSD&oldid=647406505</ref><br />
 
From an old Wikipedia draft:<ref>https://en.wikipedia.org/w/index.php?title=Draft:1P-LSD&oldid=647406505</ref><br />
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Sharing a strong structural similarity with [[ALD-52]], the chemical purportedly used in the 1960's Orange Sunshine 1P-LSD follows the less common path of modifying the 1- position on the LSD molecule which in the past has been avoided due to unpredictable results or lack of activity.<ref>http://chemistry.mdma.ch/hiveboard/palladium/pdf/Ergot%20-%20The%20Genus%20Claviceps%20(1999)/TF3168ch8.pdf</ref>
 
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Lots of debate is surrounding the action of 1P-LSD and is unclear exactly how the chemical is functional with an unconfirmed quote from [[David E. Nichols]] believing the chemical should be inactive while most other speculation believing it would simply follow the same metabolic path as ALD-52 and undergo conversion in vivo to LSD.
 
  
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"I am sure that the 1-[[propionyl]] would also hydrolyze off of an [[indole]], but I don't know whether in vivo conditions would work.  In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too.  But in the body?  I don't know the answer to that.  The compound would not be active as the N-propionyl however.  Way that LSD docks into the [[5-HT2A receptor]], the indole NH hydrogen bonds to serine 5.46.  With the propionyl, it won't fit into the receptor."<ref>http://www.shroomery.org/forums/showflat.php/Number/21106929#21106929</ref>
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''Sharing a strong structural similarity with ALD-52, the chemical purportedly used in the 1960's Orange Sunshine 1P-LSD follows the less common path of modifying the 1- position on the LSD molecule which in the past has been avoided due to unpredictable results or lack of activity.<ref>http://chemistry.mdma.ch/hiveboard/palladium/pdf/Ergot%20-%20The%20Genus%20Claviceps%20(1999)/TF3168ch8.pdf</ref>
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<!--== Effects ==
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''Lots of debate is surrounding the action of 1P-LSD and is unclear exactly how the chemical is functional with an unconfirmed quote from David E. Nichols believing the chemical should be inactive while most other speculation believing it would simply follow the same metabolic path as ALD-52 and undergo conversion in vivo to LSD.''
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''"I am sure that the 1-propionyl would also hydrolyze off of an indole, but I don't know whether in vivo conditions would work.  In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too.  But in the body?  I don't know the answer to that.  The compound would not be active as the N-propionyl however.  Way that LSD docks into the 5-HT2A receptor, the indole NH hydrogen bonds to serine 5.46.  With the propionyl, it won't fit into the receptor."<ref>http://www.shroomery.org/forums/showflat.php/Number/21106929#21106929</ref>''
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<!--== Brief overview - What is 1P-LSD? ==
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== Effects ==
  
 
== Pharmacology, toxicity and general safety ==
 
== Pharmacology, toxicity and general safety ==

Latest revision as of 08:42, 24 February 2015

Safety profile Note error.png
Category:
  • Psychedelic
Main effects:
  • Anecdotal report of being indistinguishable from LSD.[1]
  • Possible main effects: open and closed eye visuals, euphoria, change in perception of time.
Side effects:
  • Possible side effects: nausea, vasoconstriction, unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing
Health risks:
  • Possible mental side effects: paranoia, fear, and panic. Hallucinogen persisting perception disorder.
  • No other known specific physical risks at this time.
Important safety remarks:
  • 1P-LSD is a research chemical not mentioned in academic literature. The LD50 (median lethal dose) or long term / pharmacological / behavioral risks are not known.
  • 1P-LSD is likely a controlled substance analogue under US law if intended for human consumption.
  • This chemical is active in the microgram (µg) range. Please use caution when working with this substance, a calibrated milligram scale and liquid measurement are vital.
  • Do not ingest 1P-LSD when your mental or physical health is poor. Observe the set and setting.


Chemical and physical properties

1P-LSD
  • Systematic (IUPAC) name: (6aR,9R)-4-propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
  • Synonym: 1-Propionyl-lysergic acid diethylamide

From an old Wikipedia draft:[2]

Sharing a strong structural similarity with ALD-52, the chemical purportedly used in the 1960's Orange Sunshine 1P-LSD follows the less common path of modifying the 1- position on the LSD molecule which in the past has been avoided due to unpredictable results or lack of activity.[3] Lots of debate is surrounding the action of 1P-LSD and is unclear exactly how the chemical is functional with an unconfirmed quote from David E. Nichols believing the chemical should be inactive while most other speculation believing it would simply follow the same metabolic path as ALD-52 and undergo conversion in vivo to LSD.

"I am sure that the 1-propionyl would also hydrolyze off of an indole, but I don't know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don't know the answer to that. The compound would not be active as the N-propionyl however. Way that LSD docks into the 5-HT2A receptor, the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won't fit into the receptor."[4]

Links

References

  1. ↑ bluelight.org: The Big & Dandy 1P-LSD (1-propionyl-lysergic acid diethylamide) Thread
  2. ↑ https://en.wikipedia.org/w/index.php?title=Draft:1P-LSD&oldid=647406505
  3. ↑ http://chemistry.mdma.ch/hiveboard/palladium/pdf/Ergot%20-%20The%20Genus%20Claviceps%20(1999)/TF3168ch8.pdf
  4. ↑ http://www.shroomery.org/forums/showflat.php/Number/21106929#21106929
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