Separating 5-MeO-DMT from DMT

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Warning: The validity of this tek working or not is in dispute. DON'T USE THIS TEK UNTIL THIS IS RESOLVED! [1]

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Note: This page is a transcription of 69ron's Separating 5-MeO-DMT from DMT[2]. The content is to remain accurate as such.

5-MeO-DMT citrate is nearly insoluble in acetone, but DMT citrate is very soluble in acetone.

Here is the method recommended by SWIM to separate 5-MeO-DMT from DMT.

To separate the two, dissolve freebase 5-MeO-DMT and freebase DMT in a small amount of acetone, add 10% citric acid solution pre-dissolved in acetone, stir and 5-MeO-DMT citrate precipitates out of the acetone and the DMT citrate stays dissolved in the acetone along with the remaining excess citric acid.

Citrate Acetone Precipitation

Dissolve the mixed alkaloids in acetone. Add 10% citric acid solution (pre-dissolved in acetone). This causes a cloud to form. Continue adding the citric acid solution and precipitates start falling out of the acetone. Stop adding citric acid solution when no more precipitates form. The precipitates will contain the 5-MeO-DMT citrate (and 5-HO-DMT citrate if there was any). The acetone will contain DMT citrate. Pour off the acetone through a filter and wash the precipitates with acetone to obtain 5-MeO-DMT citrate. NOTE: Before vaporizing 5-MeO-DMT, it needs to be freebased.

To separate 5-MeO-DMT from 5-HO-DMT SWIM does the following during an A/B extraction before doing the Citrate Acetone Precipitation above:

Selective Solvent A/B Extraction

During the freebase phase of an A/B extraction, first extract the freebase DMT and 5-MeO-DMT with naphtha, heptane, xylene, or d-limonene. The freebase 5-HO-DMT will not get extracted because it’s insoluble in those solvents. You can then extract freebase 5-HO-DMT with DCM (dichloromethane), ether, or chloroform.


5-MeO-DMT is sort of a dissociative on it’s own. It doesn’t usually produce many visual effects. High doses usually cause one to experience “the void”. When vaporizing even small doses (2-10 mg) it can be terrifying for some people because the effects hit really fast (before you exhale). Probably the most pleasant method of using 5-MeO-DMT is sublingually as a salt. This way the trip is much less jolting. The peak gradually builds and the whole trip lasts longer. SWIM enjoys it much more this way, but not if freebase is used because it BURNS LIKE HELL. Instead 5-MeO-DMT fumarate is used sublingually. 5-MeO-DMT fumarate doesn’t burn. It’s mild and tastes like sour plastic. Just 5 mg under the tongue is enough for pretty good effects. There’s not much visuals and there are a lot of mental effects going on. It’s mentally very active and similar to LSD. There are some unusually sensations felt that are hard to describe. 5-MeO-DMT in some ways is like alcohol, in that you feel a little cloudy. At least this is how SWIM feels from it.

Once SWIM accidentally vaporized 20 mg of 5-MeO-DMT thinking it was DMT. It was an extremely frightening experience. There were very few visuals, mostly just visual distortions, but mentally nothing made any sense at all. SWIMs heart was racing. He had a hard time breathing. SWIM felt he had gone completely insane and was suffering brain damage. It was hard to make sense of anything at all. The experience was over in about 15 minutes and SWIM was so glad to be back to normal. SWIM does not enjoy high doses of 5-MeO-DMT, and most of his friends feel the same way. But small doses sublingually can be very nice.


  1. Dispute about this tek working or not [1][2]
  2. Separating 5-MeO-DMT from DMT by 69ron [3]