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  • Psychedelic, Tryptamine, Synthetic
Main effects:
  • Comparable to other psychedelic tryptamines (e.g. psilocin, 4-aco-DMT): Open/closed-eye visuals, Distorted sense of time, Philosophical insights, Possible ego-loss or contact with non-human entities
Side effects:
  • There are anecdotal reports of body tremors and elevated heart rate. Anxiety, confusion, and motor impairment are among possible side effects as with many psychedelics.

Brief overview - What is 4-AcO-MET?

4-acetoxy-N-methyl-N-ethyltryptamine, aka Metacetin; is a synthetic psychedelic tryptamine.

Metacetin seems to be a fairly safe psychedelic comparable to other tryptamines of its class, but considering that it seems to have a much shorter history of human use it is best to always stay cautious. No deaths have been reported from ingestion of metacetin. There are anecdotal reports of body tremors and elevated heart rate.

It is believed that 4-AcO-MET will metabolize into 4-HO-MET once it enters the body, but no studies have been done to test this theory. Based on anecdotal reports, it seems possible that some 4-AcO-MET remains and has its own biological activities.

Chemical and physical properties

Metacetin or 4-acetoxy-N-methyl-N-ethyltryptamine


CAS number - 246-87-2

ChemSpider - 26633897

Chemical data

Formula - C15H20N2O2

Mol. mass - 260.33 g/mol

Dosages and consumption methods

Metacetin dosage charts are VERY tentative because of its short human history so far. Given here is the same dosage chart associated with 4-HO-MET, as they seem to be on relatively equal terms. Always start low and proceed with caution.


Threshold - 2-8 mg

Light - 5-10 mg

Common - 8-15 mg

Strong - 10-20 mg

Heavy - 25+ mg