Psilocin and Psilocybin

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Brief overview - What is Bufotenine?

Chemical and physical properties


4-HO-DMT - 4-Hydroxy-N,N-dimethyl-tryptamine

Freebase Psilocin

  • CAS Registry Number: 520-53-6
  • Composition: C12H16N2O
  • Molecular Weight: 204.27 g/mol
  • Melting Point: 103-104°C (TIHKAL) , 173-176°C (Merck Index)
  • XLogP3: 2.1 (PubChem)
  • Colorimetric reagent results: Here
  • Stability/Degradation: Unstable in solution, especially alkaline solution (Merck Index).
  • Solubility:

Soluble in 70% ethanol. Poorly soluble in dry ethanol, and poorly soluble in ethanol less than 60%. Very slightly soluble in water (sources: Merck Index , scientific publications)


4-PO-DMT - O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine

Psilocybin (Psilocin Phosphate Ester)

  • CAS Registry Number: 520-52-5
  • Composition: C12H17N2O4P
  • Molecular Weight: 284.248141 g/mol
  • Melting Point: 220-228° from boiling water; 185-195° from boiling methanol (Merck Index)
  • XLogP3: -1.6 (PubChem)
  • Colorimetric reagent results: Here
  • Stability/Degradation: Dephosphorylated into Psilocin under acidic conditions. Also when ingested, by phosphatases enzymes.
  • Solubility:

Soluble in water. Soluble in 20 parts boiling water (= 0.79g/ml in boiling water), 120 parts boiling methanol (= 0.0932g/ml in boiling methanol); very soluble in 70% methanol saturated with KNO3, soluble in dry methanol, difficultly soluble in ethanol, increasingly less soluble in methanol less than 80%. Practically insoluble in chloroform, benzene (sources: Merck Index , scientific publications)


Pharmacology, toxicity and general safety

Plants containing bufotenine

Extraction teks

Dosages and consumption methods

History of usage

Analysis of bufotenine

Scientific publications

Other links of interest