Phenetylamine

What is Phenetylamine / PEA

Phenetylamine is a naturaly occuring alkaloid, and it is the base structure for several other psychedelic alkaloids. It is apparently inactive in humans by itself. An orally active psychedelic dosage was not reached with up to 1600mg (shulgin & shulgin 1991)

Chemistry and analysis

• Ultraviolet absorption spectra and apparent acidic dissociation constants were reported (Kappe and Armstrong, 1965}; a quantitative colorimetric screening method was described for urine analysis (Rutter, 1972t and TLC methods were described (Bussey and Backer, 1974). Synthesis, TLC and Gas chromatographic properties, UV spectra, and other physical properties w ere reported (Ono et al., 1976). Analysis of phenethylamine, tyramine, and octopamine from human plasma by GC/MS of the trifluoroacetate derivatives was described (Baker et al., 1980). The conformation of the aryl methoxy groups of several psychedelics was established by [13C]-NMR spectral analysis (Knittel and Makriyannis, 1981), and [13C]-NMR spectra for methoxylated phenethylamines and amphetamines were shown to be distinctive and suitable for identification (Bailey and Legault, 1983). Analysis by HPLC employing fluorescamine derivatization for detection was described (Shimamine, 1984).

• An exacting crystallographic anaJysis was made of PEA (Hornet al., 1990}. FTIR spec-tral analysis was used for PEA identification (Praisler et al., 2000).

• fragmentation patterns of some fifty-five phenethylamines were determined by a variety of mass spectrometry techniques (Kolliker and Oehme, 2004). Identification of phenethylamines with IR data analyzed with neural networks and neural networks coupled with principal component analysis was reported (Cosav et al., 2005). Assay of PEA in rat brain and human CSF by chemical ionization GC/ MS was reported (Lauber and Waldmeier, 1984), and quantitative

determination of PEA in human blood plasma was achieved by GC/ MS analysis of the heptafluorobutyrate amides (Habrdova et al., 2005).