Difference between revisions of "PKa"
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The pKa is the pH at which 50% of the alkaloid is in salt form and 50% is freebased. | The pKa is the pH at which 50% of the alkaloid is in salt form and 50% is freebased. | ||
| − | At pKa -2 1% is freebased and 99% is salted | + | * At pKa -2 1% is freebased and 99% is salted |
| − | At pKa -1 10% is freebased and 90% is salted | + | * At pKa -1 10% is freebased and 90% is salted |
| − | At pKa +0 50% is freebased and 50% is salted | + | * At pKa +0 50% is freebased and 50% is salted |
| − | At pKa +1 90% is freebased and 10% is salted | + | * At pKa +1 90% is freebased and 10% is salted |
| − | At pKa +2 99% is freebased and 1% is salted | + | * At pKa +2 99% is freebased and 1% is salted |
It’s not completely accurate to go by just the pKa of an alkaloid. There are other factors at play such as solubility of the various salts and the solubility of the freebased compound. | It’s not completely accurate to go by just the pKa of an alkaloid. There are other factors at play such as solubility of the various salts and the solubility of the freebased compound. | ||
| − | The solubility of various alkaloid salts differ from the solubility of each other and their parent freebase form. For example, DMT freebase is almost insoluble in water while DMT fumarate is water soluble but much less water soluble than DMT acetate; mescaline freebase is water soluble while mescaline sulfate is less water soluble and mescaline hydrochloride is highly water soluble, etc. | + | The solubility of various alkaloid salts differ from the solubility of each other and their parent freebase form. For example, [[DMT freebase]] is almost insoluble in water while [[DMT fumarate]] is water soluble but much less water soluble than [[DMT acetate]]; [[mescaline freebase]] is water soluble while [[mescaline sulfate]] is less water soluble and [[mescaline hydrochloride]] is highly water soluble, etc. |
== Links == | == Links == | ||
Revision as of 21:33, 27 March 2009
The pKa is the pH at which 50% of the alkaloid is in salt form and 50% is freebased.
- At pKa -2 1% is freebased and 99% is salted
- At pKa -1 10% is freebased and 90% is salted
- At pKa +0 50% is freebased and 50% is salted
- At pKa +1 90% is freebased and 10% is salted
- At pKa +2 99% is freebased and 1% is salted
It’s not completely accurate to go by just the pKa of an alkaloid. There are other factors at play such as solubility of the various salts and the solubility of the freebased compound.
The solubility of various alkaloid salts differ from the solubility of each other and their parent freebase form. For example, DMT freebase is almost insoluble in water while DMT fumarate is water soluble but much less water soluble than DMT acetate; mescaline freebase is water soluble while mescaline sulfate is less water soluble and mescaline hydrochloride is highly water soluble, etc.
