MXE

Brief overview - What is MXE?

Methoxetamine or 3-MeO-2-Oxo-PCE; is a Dissociative/Psychedelic/Anesthetic.

This compound is the birth child of rational drug design.

Chemical and physical properties

Methoextamine or (RS)2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone

Identifiers

CAS number - 1239943-76-0

ChemSpider - 24721792

Chemical data

Formula - C15H21NO2

Mol. mass - 247.33 g/mol

Pharmacology, toxicity and general safety

• • • This is all pure subjective observations and speculation from my history with other Arylcyclohexylamines.

-Pharmacology

• Mild mu-opiate Receptor Agonist, Moderate Dopamine Receptor Agonist, Mild Sigma Receptor Agonist, Moderate-High NMDA-Receptor Antagonist.

-Toxicity and Safety

• Methoxetamine is a very young compound, having only been sold to the open public for around 2 years now. Much care and respect should be taken in handling these unresearched chemicals, dosing should start very low for checking of allergies and purity. Remember to titrate your dose up very slowly; monitoring vitals, breathing, and make sure you always have help on hand and nearby.

• As mentioned before Methoxetamine was developed with rational design involved, it is a Ketamine analogue and has it's N-ethyl group chosen specifically to increase the over-all potency by weight of the compound. By altering this compound it can be dosed in smaller amounts, greatly reducing the possible risk of interstitial cystitis that may be possible from norketamine build-up in heavy Ketamine users for example.

• This compound was also originally designed for daily use in treatment of the creators Phantom Limb Syndrome/Neurological Pain/Emotional Depression, this does not in any way make it safe to dose daily. Dissociatives have a bad reputation but contrary they are not nearly as toxic as many make them out to be, this said I recommend anyone to dose only once every 2-3 weeks and even then infrequently; we are still dealing with unresearched chemicals here.

• This compound also behaves as a sedative/opioid so precautions should be taken; do not move around too much, do not mix with any sedatives such as benzodiazepines, high dose kava kava and other opioids without proper knowledge and supervision. Your heart rate might also be raised from the DRI effect, take care to not mix with any other stimulants or heavy vasodilators, or especially MAOis.

• Methoxetamine can go well with low doses of natural tryptamines, such as DMT and Psilocybin; in fact they compliment each other very well. Also some low dose phenylethylamines can mix well but please do not mix unresearched chemicals, this is highly unsafe and dangerous; please respect your mind and body.

• Always know your dose, and compound; set and setting.

Dosages and consumption methods

-Methoxetamine can be taken in various routes of administration, each one slightly changing the effects, duration, and dose required.

• The compound may be taken Nasally, Orally, Rectally, IM, and IV.

• I do not condone the latter two because of various safety and procedure reasons. Because of this I will only list subjective doses for the former three routes; keep in mind everyone doses differently and these doses will not apply for everyone.

-Nasally

Duration - 3-4 hours, + 2-3 hours of after effects.

Mild - 5-20 mg.

Moderate - 25-50 mg.

High - 60-100 mg.

Very High/M-Hole - 150-200 mg.

-Orally

Duration - 5-6 hours, + 3-4 hours of after effects.

Mild - 5-15 mg.

Moderate - 20-45 mg.

High - 50-75 mg.

Very High/M-Hole - 100-150 mg.

-Rectally

Duration - 4-5 hours, + 2-3 hours of after effects.

Mild - 5-15 mg.

Moderate - 20-40 mg.

High - 50-70 mg.

Very High/M-Hole - 80-120 mg.

History of usage

• This compound has a very small amount of history in regards to human use, many users have reported the compound to be quite pleasurable and addicting; this leads some users to use the compound daily for months. No real health problems have been reported yet but long-term users report feeling their dopamine depleted on stopping; a crash where one feels sleepy, depressed, bored, and tired for a few days after use. This can be easily avoided by spacing your use out over a span of months instead of days.

• Also precautions can be taken in order to increase the chances of receptor recovery after Methoxetamine use; such as a few grams of Piracetam the day after use as well as a mild-GABAergic drug to help counter any possible GABA neuron toxicity. Remember to keep yourself hydrated as well throughout the experience, taking all these precautions will help insure this drug will have a positive long-term history of use.

Analysis of MXE

• Various users have performed Mass Spectrometry tests on various samples, but do to various skills of chemists and samples no formal literature on Methoxetamine has been analyzed and published to date.

Other links of interest

http://en.wikipedia.org/wiki/Methoxetamine - Methoxetamine Wiki

http://www.vice.com/read/interview-with-ketamine-chemist-704-v18n2 - Interview with the Creator of Methoxetamine