XlogP

Lower XlogP values are more water soluble, and higher XlogP values are more non-polar soluble.

Alkaloid XlogP list

• 0.1 - 6-methoxy-2-methyl-beta-Carboline
• 0.7 - Beta-carboline, 6-methoxy-1,2-dimethyl-1,2-Dimethyl-2H-beta-carbolin-6-yl methyl ether
• 1.0 - 5-HO-Tryptamine (serotonin)
• 1.3 - 5-HO-DMT N-oxide (Bufotenine N-oxide)
• 1.6 - 5-HO-DMT (bufotenine)
• 1.7 - N-Methylserotonin
• 1.7 - DMT N-oxide (Dimethyltryptamine N-oxide)
• 1.7 - 5-MeO-NMT (5-Methoxy-N-methyltryptamine)
• 1.7 - 2-Methyl-1,2,3,4-tetrahydro-beta-carboline
• 1.8 - NMT (N-Methyltryptamine)
• 1.9 - 5-MeO-DMT (methoxybufotenin)
• 2.0 - DMT (Dimethyltryptamine)

Solvent XlogP list

• -0.7 - DMSO
• -0.5 - Methanol
• -0.1 - Ethyl Alcohol
• 0.2 - Acetone
• 0.4 - IPA
• 0.4 - MEK (Methyl Ethyl Ketone)
• 0.7 - Ethyl Acetate
• 0.9 - Ethyl Ether
• 1.5 - DCM
• 2.1 - Chloroform
• 2.5 - Toluene
• 2.5 - Xylene
• 3.7 - Limonene
• 4.3 - Heptane (similar to naphtha)

Note:

Toluene and xylene, will only usually extract alkaloids with an XlogP of about 1.7 or higher. Heptane/naphtha will only extract the highly non-polar alkaloids with an XlogP of about 1.8 or higher (5-MeO-DMT, DMT, and NMT). As the solvent gets more non-polar, it extracts less and less alkaloids. XlogP calculations are never completely accurate and there are always exceptions to these solubility guides.

Links

• 69ron explaining XlogP