Known substance-interactions and their effects

WARNING:

THIS THREAD IS STILL 'IN THE MAKING' AND CAN CONTAIN WRONG DATA! DO NOT USE THIS THREAD AS A DRUG-INTERACTION GUIDE YET!

Introduction

This article is about the interactions and effects of mixing different entheogens, both with each other and with medicine. Some combinations have a good synergy while others can be a DEADLY combination! Taking any substance carries a high responsibility, please read the WARNING section with great care!

Warning!

THIS THREAD IS STILL 'IN THE MAKING' AND CAN CONTAIN WRONG DATA! DO NOT USE THIS THREAD AS A DRUG-INTERACTION GUIDE YET!
THIS THREAD IS STILL 'IN THE MAKING' AND CAN CONTAIN WRONG DATA! DO NOT USE THIS THREAD AS A DRUG-INTERACTION GUIDE YET!

Even though the interactions of certain substances are described here, it is extremely important to be safe at all times! This article is only to give information about interactions and their effects, this article is NOT meant for advice on taking any combination!

Many interactions described here are subjective descriptions, so what is shown here is only an indication on how certain combinations can affect you and how safe they are. Many times those effects are dependent on dose (of each substance), route of administration, timeline of administration, set and setting, your mood, your physical health, your mental health and many other factors.

Psychedelics

DMT

Some report dysphoria at lower doses. I (House) do not find this to be the case I find low doses incredibly euphoric. Higher doses can be known to go beyond human emotions and concepts. Higher doses of DMT are also known to cause strange bodily hallucinations like the feeling that you have stopped breathing, or that your heart has stopped beating. These hallucinations are common and can be countered with conscious relaxation and meditation prior and during the experience. You do not have to submit, per se, but beware that you may have to let go of certain intensities during the experience. It can easily be the most "intense" experience of your life for some people, and this is *NOT* a bad thing!

DMT + Harmalas (MAOI)

DMT + Harmalas (MAOI)
Combination:	OK
Generic information:	Harmalas potentiate and prolong the effects of DMT, while at the same time it adds a slight psychedelic effect of it's own. For DMT to be orally active, a MAOI is mandatory.
User descriptions:	House Oral activation. Potentiation. Slowed-down effect. The two go hand in hand creating a perfect synergy.

DMT + Mushrooms (psilocybin)

DMT + Mushrooms (psilocybin)
Combination:	OK
Generic information:	...
User descriptions:	House Another profound synergy that seems to unlock the potential of the mushroom. Either @ peak or after. The Traveler Euphoric

DMT + LSD

DMT + LSD
Combination:	OK
Generic information:	...
User descriptions:	House Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak. The Traveler Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.

DMT + MDMA

DMT + MDMA
Combination:	OK
Generic information:	...
User descriptions:	House Euphoric, not as deep of a trip, but there is zero anxiety present which can be useful and awesome in it's own right.

DMT + Mescaline

DMT + Mescaline
Combination:	OK But...
Generic information:	...
User descriptions:	House Great synergy here. Potentiates the mescaline and smooths it out. The Traveler The mescaline seems to 'dull' the DMT. So there was not as much effects from smoking the DMT on Mescaline as you would expect.

DMT + Alcohol

DMT + Alcohol
Combination:	SAFE But...
Generic information:	...
User descriptions:	House I find that combining the spice with a carcinogenic neurotoxin like alcohol completely negates the experience and masks it with toxic nullification (Yes, I am quite biased) The Traveler The alcohol did have a negative impact on me. I tried to drink a few beers beforehand to mitigate the anxiety of the pharmahuasca but that only resulted in dulling down, confusion and nausea.

DMT + Cannabis

DMT + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House OK, although some people don't like it. If you are a daily cannabis smoker it shouldn't be a problem, but if you get anxiety from using Cannabis occasionally it may be wise not to mix it with DMT. Purges If I smoke DMT / Changa 1-2 hrs after my last hit of cannabis it is great, if I smoke DMT & Cannabis together it is not so great.

Harmalas (MAOI)

Side effects include contraindication with certain substances. Make sure you understand interactions with substances before using them! At higher doses users experience nausea and vomiting, but this also isn't necessarily a bad thing, since harmalas are anti-parasitic, purging is often considered cleansing to both the body and the mind. Chest pressure is also common with ayahuasca. Feelings of having something heavy sitting on you. This is normal and if experienced just relax and let it be, it's part of the serpents coil.

Harmalas (MAOI) + Caffeine

Harmalas + caffeine
Combination:	OK But...
Generic information:	...
User descriptions:	House I personally don't mind a low dose of harmalas on top of caffeine, it can counter act the sedation from the harmalas in the right dosages. Too much of both and you will experience uncomfortable heart rate. So new users to this synergy take caution and start low! gory dkalz I had one cup of average strength coffee about 2 hours after smoking changa and I got very edgy and nervous. Coffee barely even wakes me up but I was wired for about an hour. Quite uncomfortable. obliguhl For me, a cup of yerba matè plus ayahuasca equals awful experience. There seem to be some people who can't take caffeine and ayahuasca

Harmalas (MAOI) + Kava kava

Harmalas + Kava Kava
Combination:	BAD IDEA!
Generic information:	Hypertension, Serotonin Syndrome. Death can result out of this combination!
User descriptions:

Oral Harmalas (MAOI) + Opioids

Oral Harmalas (MAOI) + Opioids
Combination:	BAD IDEA!
Generic information:	Has the potential for adverse reactions, namely CNS excitation or depression (resulting in high or low blood pressure).
User descriptions:

Mushrooms (psilocybin)

I (House) think the most common side effect I hear about with shrooms is stomach discomfort. A lot of people don't know that you really are not supposed to consume any kind of raw mushroom. It's a rare case in the culinary and medicinal fields where raw mushrooms are told to be ingested. (I can think of a few exceptions, of course.) So for some ingesting the raw material can be very nauseating, myself included. Making a tea or the lemon tek is the way to go. By soaking raw mushrooms in lime juice, the citric acid literally cooks the mushrooms breaking down the cell walls. This is also known as a ceviche in the cooking world. Personally I just slip the shot of lime juice with the mushrooms in it back, it tastes good and I don't experience nausea this way. Some people filter out the mushroom material from the solution. Experiment. Taking too many mushrooms can lead to a feeling of being poisoned, but as far as I know no one has ever died from taking them on their own. Dose accordingly!

Mushrooms + Cannabis

Mushrooms + Cannabis
Combination:	Depends
Generic information:	...
User descriptions:	House I won't use mushrooms without cannabis; Noticeable synergy and eases any anxiety present. Some people who don't use cannabis often find that this combo causes paranoia.

Mushrooms + MDMA

Mushrooms + MDMA
Combination:	OK
Generic information:	...
User descriptions:	House OK. Profound synergy. Great for meditation and dance

Mushrooms + Harmalas (MAOI)

Mushrooms + Harmala (MAOI)
Combination:	SAFE But
Generic information:	...
User descriptions:	House I personally love the harmala + mushrooms synergy, but some have noted that the harmalas potentiate the mushrooms very much and have had rough trips! If you want to experiment with this combo, start low and work your way up!

Mushrooms + Alcohol

Mushrooms + Alcohol
Combination:	SAFE But
Generic information:	...
User descriptions:	Bedazzle Tends to dull the trip, slower than cocaine however. Also, people tend to get negative from this combo. One might hypothesize that alcohol tends to turn the trip in a darker direction.

Mushrooms + Cocaine

Mushrooms + Cocaine
Combination:	SAFE But
Generic information:	...
User descriptions:	Bedazzle Tends to dull the trip, or even stop it dead in it's tracks.

LSD

LSD is a potent vasoconstricting substance. This means it causes an increase in blood pressure by tightening the blood vessels in the body. This can be countered with vasodilating substances. Some find that oral hash completely diminishes the vasoconstriction. I like using transdermal magnesium prior to a dose to also help with things like jaw tension. Also, conscious relaxation, deep breaths, and massage (even done by the self) can help curb tension experienced from the drug. If you feel over stimulated or uncomfortable, you probably need to "Flow", so to speak. Get up, stretch, dance around, laugh, have an orgasm, be creative, play a musical instrument, take a hot shower. Things like this help with getting energy flowing and making meditation easier. Eat a bit of fruit on the come-up if you feel some unease! Many people find cannabis greatly eases the transition, but of course not everybody.

LSD + DMT

LSD + DMT
Combination:	OK
Generic information:	...
User descriptions:	House Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak. The Traveler Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.

LSD + Ayahuasca + DMT

LSD + Ayahuasca +DMT
Combination:	OK
Generic information:	...
User descriptions:	House This is my favorite synergy of all time. First take the LSD, then take a comfortable dose of banisteriopsis caapi tea, then smoke as much DMT/Changa as you desire. Absolutely astonishing.

LSD + Mushrooms

LSD + Mushrooms
Combination:	Depends
Generic information:	...
User descriptions:	House A lot of people don't like this combination for some reason- both drugs are just so powerful they may not need to go together, with that said however some people like the combo and it is OK to take.

LSD + MDMA

LSD + MDMA
Combination:	OK
Generic information:	...
User descriptions:	House Classic Combo. Take at the same time or let the acid kick in then take the MDMA. Profound synergy! The Traveler The MDMA gives a euphoric effect to the LSD experience.

LSD + MDAI

LSD + MDAI
Combination:	OK
Generic information:	...
User descriptions:	The Traveler The MDAI gives a euphoric effect to the LSD experience.

LSD + Mescaline

LSD + Mescaline
Combination:	OK
Generic information:	...
User descriptions:	House Nice synergy but it's hard to tell how each drug is affecting each other. A bit like LSD + MDMA but a deeper, so to speak.

LSD + Cannabis

LSD + Cannabis
Combination:	Depends
Generic information:	...
User descriptions:	House Cannabis vasodilates the vasoconstriction of LSD especially if taken orally. Potentiates and smooths out the trip. Great for daily smokers. Has been known to cause anxiety in those who don't use Cannabis too often. The Traveler I almost never use cannabis, I wanted to use the cannabis versus the stimulation of the LSD. It gave me more visuals but it also made me dizzy. Overall I did not like it. Universecannon Definitely has led to a bunch of paranoia at times (I'm prone to that with weed alone though) but if combined carefully it can be totally worth it although i never do it anymore (no lsd). If a large amount is smoked at the peak-especially if i have a low tolerance- then it can really catapult the experience into a sort of out of body type thing with full blown 3-d immerse visions, IME

LSD + MXE

LSD + MXE
Combination:	Depends
Generic information:	...
User descriptions:	Aetherius Rimor Did 30mg of MXE in the 2nd hour of 2 hits. That's the only time I've not been at home and unable to verbalize/coordinate movement. Luckily that's what designated drivers are for! Won't combine them again. Definitely stronger effects than same dose of each independent of each other. The Traveler The MXE potentiates the LSD effects with more visuals but it also significantly alters motor function to the point of immobility at high doses. Pandora Radical and profound potentiation/synergy. 12+ hour trip and much longer to sleep. I really love the synergy of LSD+MXE but I'm the kind of person who naturally chills during a trip, so being pancaked by effects is just an extra plus for me.

LSD + Harmalas (MAOI)

LSD + Harmalas (MAOI)
Combination:	Depends
Generic information:	...
User descriptions:	House You MUST make sure you have pure LSD, however! You do not want to mix harmala (RIMA, MAOI) with an unknown drug laid on blotter. It's great taken with a dose or taken after the dose has kicked in, as the vasodilation of the harmala counters the vasoconstriction of the LSD. Enoon Super strong synergy, stronger than usual visuals, visions, OBE, but also nausea, imobility and substatial amount of apprehension

Mescaline

Mescaline is a phenethylamine that does not have an amphetamine group on the molecule, unlike MDMA. This allows it to be able to be used with harmalas without contraindication. I (House) would describe it as ancient, wise, stimulating, dreamy, empathic, psychedelic, and long lasting. If there was a divine, this would be it. It is very forgiving in high doses unlike some of the other psychedelics in the kingdom. It is found as an insecticide in the cacti family, and has been shown to be produced in higher amounts by stressed species.

Mescaline + Caffeine

Mescaline + Caffeine
Combination:	OK
Generic information:	...
User descriptions:	House A great way to potentiate your mescaline dose is with caffeine, especially coffee. Yerba mate and other teas are good too. Even the days after a trip, a nice cup gets you right back in that lovely state-of-mind. Some may find this combo too stimulating, however. The coffee can also be used to get digestion flowing if you are having indigestion from the cactus.

Mescaline + Cannabis

Mescaline + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House Noticeable potentiation and takes the edge off the stimulation subsequently. These two go hand-in-hand if you are a regular cannabis user. If not, start low!

Mescaline + Harmalas (MAOI)

Mescaline + Harmala
Combination:	OK
Generic information:	...
User descriptions:	House No contraindication here. A nice synergy. The harmala takes away some of the stimulation of the mescaline and makes the experience more dreamy.

Iboga

Careful with this one! Much research and tests must be done before ingesting this substance. It is clinically proven to slow down a rhythm of the heart beat and has killed people because of this. A heart panel and EKG are common tests preformed before ingesting this substance. Please beware of this and do a lot of research before even considering this very profound medicine! Side effects include disorientation, immobility, nausea, in high doses for very long periods of time. Some people still can't drive a car 1 week after a flood dose, for example.

Iboga + LSD

Iboga + LSD
Combination:	OK
Generic information:	...
User descriptions:	House LSD becomes much more potent after Iboga and I would suggest taking it sometime between 1-7 days after taking a low dose of Iboga. For me I find that the LSD really puts the teachings of the Iboga into perspective. Be careful though, there is a definitely potentiation.

Iboga + Mushrooms

Iboga + Mushrooms
Combination:	OK
Generic information:	...
User descriptions:	House I find that psilocybe mushrooms are a really great synergy. They seem to kick in the Iboga about 3x as hard, so a low dose of both makes for a good journey. Euphoric, meditative, deep combination. Great for sorting things out in your life.

Iboga + Cannabis

Iboga + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House Great synergy with Iboga and cannabis. Noticeable potentiation. Also takes care of the intense nausea with higher doses of Iboga a bit. I believe this synergy is even used traditionally in some instances.

Iboga + Harmalas (MAOI)

Iboga + Harmala
Combination:	Depends
Generic information:	...
User descriptions:	House While myself and others have found a low dose of harmala to be a nice synergy with Iboga, others have found the combination too intense. Start low and work your way up.

Iboga + Coffee

Iboga + Coffee
Combination:	Depends
Generic information:	...
User descriptions:	House I personally love a low dose of Iboga with a good cup of coffee, and cannabis. I find it stimulating both physically and with the clarity of mind. Some may find this too stimulating. Don't expect to sleep the night of taking this combo!

MDMA

The most common side effects of MDMA are jaw tension, feeling burnt-out the next day, and it's minimal amount of neurotoxicity. A lot of people "pre load" with substances that are neuroprotectant before, during, and after the experience. Neuroprotectants include cannabis, nootropics, vitamin C, 5-HTP, and others. Jaw tension can be countered again with transdermal magnesium, conscious relaxation, meditation and massage. As for feeling burnt-out, try to only redose a small amount one time or not at all. Constantly redosing can cause more burnout srensations. Also dosing too high. You might want to touch, hug, kiss, and tell how much you love everything around you, too.

Taking MDMA with MAOI and certain prescription medications can lead to seratonin syndrome and even death so plesse be careful!

MDMA + Harmalas (MAOI)

MDMA + Harmalas (MAOI)
Combination:	BAD IDEA!
Generic information:	Hypertension, Serotonin Syndrome. Death can result out of this combination!
User descriptions:

MDMA + Cannabis

MDMA + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House Great synergy with MDMA and cannabis. Smooths out the stimulation. Biologically speaking, the cannabis actually works as a neuroprotectant against the neurotoxicity of MDMA. They go hand-in-hand if you are a fan of cannabis!

MDMA + LSD + Ketamine + Cannabis

MDMA + LSD + Ketamine + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	Purges Better than OK for me. Have had some of the best nights of my life with this cocktail.

Ketamine

Ketamine + LSD

Ketamine + LSD
Combination:	OK
Generic information:	...
User descriptions:	House This is a pretty classic and noteable synergy that many people love. The K takes you very deep into yourself, and away from yourself at the same time. Purges OK. Similar to the 2CB combo, be careful, both of these drugs have a tendency to be a bit mind bending, and in combo, expect it to get wild!

Ketamine + LSD + Cannabis

Ketamine + LSD + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House Love it! Purges OK. You will get lost in the deepest recesses of your mind for quite some time, I love comatose tripping, but it isn't for everyone.

Ketamine + Harmalas (MAOI)

Ketamine + Harmala
Combination:	BAD IDEA!
Generic information:	Harmalas are contraindicated with dissociatives, this means you do not want to combine them. At high doses the cardiovascular system can shut down.
User descriptions:	House Made the mistake of trying changa on top of LSD + K once and I will never do that again. Intense bronchial constriction and chest pain was noted.

Ketamine + Cannabis

Ketamine + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House I love coming back from the ketamine trance and smoking cannabis. Great for meditation and integration if you enjoy cannabis!

Ketamine + DMT

Ketamine + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House DMT on Ketamine is out of this world stellar. The dissociative properties of ketamine completely eliminate any anxiety present, and the two work together to take you deep into whatever it is that we are...

Ketamine + LSD + DMT

Ketamine + LSD + DMT
Combination:	OK
Generic information:	...
User descriptions:	House Throwing LSD into the mix is just that much more powerful.

Salvia Divinorum

Salvia + DMT

Salvia + DMT
Combination:	OK
Generic information:	...
User descriptions:	Mysemelf OK. can be extremely disturbing though or unbelievably profound and real.

Salvia + Changa + Cannabis

Salvia + Changa + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	Mysemelf This is probably my favorite mix. I've had some of my deepest experiences mixing these three including one with multiple breakthroughs one on top of the other cascading deeper with a new universe created and destroyed each time.

Salvia + Cannabis

Salvia + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	Mysemelf This is a very therapeutic anesthetic. This kills pain very well and leaves me in a dreamy visionary state without the mind warping dissociating effects that salvia has on its own. As long as you don't go heavy on the salvia!

RC's

2C-B

2C-B + Ketamine

2C-B + Ketamine
Combination:	Depends
Generic information:	...
User descriptions:	Purges Have seen 2 people lose the plot on this combo, so be careful. For me, it subdues the edginess of the phenethylamine buzz, while adding a trippy colourful edge to the Ketamine. Can get confusing, which I think was why people freaked out a bit.

MDMA + 2CB + K + Cannabis

MDMA + 2CB + K + Cannabis
Combination:	Depends
Generic information:	...
User descriptions:	Purges Similar to the above, moar euphoria, but again please be careful with dosages.

2C-I

2C-I + Cannabis

2C-I + Cannabis
Combination:	Depends
Generic information:	...
User descriptions:	Purges made me feel sick, smoking anything on 2CI wasn't nice.

MXE

MXE + Cannabis

MXE + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	Purges OK. deep, visual, introspective, make sure you don't have anything to do / people to entertain as chances are you will be lost in thought. Did experience a little muscle tremoring, but less than 2CI on its own.

5-MeO-DALT + MXE

5-MeO-DALT + MXE
Combination:	Depends
Generic information:	...
User descriptions:	gory dkalz While on ~50mg 5-MeO-DALT orally I did a little test bump of 15 mg MXE insufflated and within minutes felt my heart rate go up and felt very dizzy. Thought that I had finally done it and mixed the wrong stuff and I would have to go to the ER but it stopped escalating and I just waited it out.

Medicine

SSRI/SSRE

Harmalas (MAOI) + SSRI/SSRE

Harmalas + Kava Kava
Combination:	BAD IDEA!
Generic information:	Hypertension, Serotonin Syndrome. Death can result out of this combination!
User descriptions:

Other

Kava Kava

Kava Kava + DMT

Kava Kava + DMT
Combination:	OK
Generic information:	...
User descriptions:	House Kava kava is relaxing and aids in dissipating pre-flight anxiety. A warm cup is great after DMT insufflation or vaporization. There is a noticeable synergy between the two and no discomfort or side effects have been noted.

Kava Kava + LSD

Kava Kava + LSD
Combination:	OK
Generic information:	...
User descriptions:	House Kava Kava after the peak of LSD when it's wearing off is a great way to take the edge off and get some rest. It's very effective and enjoyable this way with no side effects noted.

Kava Kava + Cannabis

Kava Kava + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House Nice synergy. Very relaxing.

Caffeine

Mushrooms + Caffeine

Mushrooms + Caffeine
Combination:	Depends
Generic information:	...
User descriptions:	obliguhl Not so good. Caffeine disturbs the mushroom flow.

Links

• 'Known drug-interactions' Wiki page