Chilled Acetone with IPA and Naphtha
Contents
Introduction
This TEK uses freezer chilled acetone[1] to extract salvinorin while minimizing the extraction of other plant material. The dry residue is washed with naphtha and then recrystallized in boiling 99% IPA[2] with a cosolvent naphtha addition[3].
Safety
Do not proceed unless you are familiar with handling acetone, 99% IPA, and naphtha. If you are not familiar with these chemicals, learn about their safety and make your personal adult decision on using them or not.
Salvinorin is a powerful substance. Proper dose and a sitter in a controlled environment are important (involuntary movement has been reported).
Following these suggestions does not guarantee safety. Proceed at your personal discretion.
Steps
Step 1
Place ~100g of dry salvia leaves in a quart mason jar. Leaves do not need to be ground, but some pushing/compressing will be needed to make them fit. Cool leaves and jar in the refrigerator before the next step.
Step 2
Add about 1/3 of a quart of freezer chilled acetone and cover with an acetone resistant lid such as the type pictured below:
Shake for 60s. Uncover and use metal ring to screw on a coffee filter, tear off excess filter paper, and pour acetone into new quart jar (a small puncture hole may be needed at the top of the filter for air flow if wet). Repeat this extraction two more times to obtain about 3/4 of a quart of extract (some acetone will remain on leaves).
Step 3
Place extract with acetone resistant lid in freezer until sediment stops forming (~overnight). Decant to shallow glass baking dish leaving solids behind.
Step 4
Evaporate acetone in a well ventilated area. It is recommended to avoid direct sunlight. Some water will be absorbed and a fan can speed evaporation towards the end when mostly water remains. Scrape up green powdery residue and transfer it to a small mason jar.
Step 5
Wash powder with naphtha. Allow time to settle and ensure naphtha is clear before decanting to not lose any product. Repeat until solvent is no longer a deep green (light green is OK). Allow napthata to evaporate.
Step 6
Washed powder will still be green. Dissolve it in warm/boiling 99% IPA leaving any insoluble matter behind. Use a hot water bath to heat up the IPA (do not have flames anywhere near solvents).
Step 7
Allow IPA too cool and add an equal volume of naphtha. Place cloudy solution in freezer for several days. White xtals will grow over time, for example:
Decant green liquid, rinse with Naphtha, and recover xtals. Typical yield is 0.2% to 0.3% (100g of dry leaf will give ~250mg of white powder). Optionally, dissolve product in acetone and evaporate slowly to yield larger crystals (for cosmetic purposes).
Product Information
This produces a relatively pure powder thought to have ~ 80% of salvinorin A[4]. One milligram is considered a large dose when vaporized. A potential method of dosing is dissolving the powder in a known volume of in acetone (which saturates at about ~20mg/ml) and calculate the dosage per drop (measure the drop weight on a scale, drops are typically ~20mg wich can carry up to ~0.5mg of product if it is made near saturation). Verify that acetone does not evaporate from dropper bottle which would throw off the dosage. Add the desired dosage by counting drops to your smoking device and allow the acetone to fully evaporate. High vaping temperatures are not required and it has been reported that on an e-mesh a 180C setting can be sufficient[5].
