Known substance-interactions and their effects

WARNING:

THIS THREAD IS STILL 'IN THE MAKING' AND CAN CONTAIN WRONG DATA! DO NOT USE THIS THREAD AS A DRUG-INTERACTION GUIDE YET!

Introduction

This article is about the interactions and effects of mixing different entheogens, both with each other and with medicine. Some combinations have a good synergy while others can be a DEADLY combination! Taking any substance carries a high responsibility, please read the WARNING section with great care!

Warning!

THIS THREAD IS STILL 'IN THE MAKING' AND CAN CONTAIN WRONG DATA! DO NOT USE THIS THREAD AS A DRUG-INTERACTION GUIDE YET!
THIS THREAD IS STILL 'IN THE MAKING' AND CAN CONTAIN WRONG DATA! DO NOT USE THIS THREAD AS A DRUG-INTERACTION GUIDE YET!

Even though the interactions of certain substances are described here, it is extremely important to be safe at all times! This article is only to give information about interactions and their effects, this article is NOT meant for advice on taking any combination!

Many interactions described here are subjective descriptions, so what is shown here is only an indication on how certain combinations can affect you and how safe they are. Many times those effects are dependent on dose (of each substance), route of administration, timeline of administration, set and setting, your mood, your physical health, your mental health and many other factors.

Psychedelics

DMT

Some report dysphoria at lower doses. I (House) do not find this to be the case I find low doses incredibly euphoric. Higher doses can be known to go beyond human emotions and concepts. Higher doses of DMT are also known to cause strange bodily hallucinations like the feeling that you have stopped breathing, or that your heart has stopped beating. These hallucinations are common and can be countered with conscious relaxation and meditation prior and during the experience. You do not have to submit, per se, but beware that you may have to let go of certain intensities during the experience. It can easily be the most "intense" experience of your life for some people, and this is *NOT* a bad thing!

DMT + Harmalas (MAOI)

DMT + Harmalas (MAOI)
Combination:	OK
Generic information:	Harmalas potentiate and prolong the effects of DMT, while at the same time it adds a slight psychedelic effect of it's own. For DMT to be orally active, a MAOI is mandatory.
User descriptions:	House Oral activation. Potentiation. Slowed-down effect. The two go hand in hand creating a perfect synergy.

DMT + Mushrooms (psilocybin)

DMT + Mushrooms (psilocybin)
Combination:	OK
Generic information:	...
User descriptions:	House Another profound synergy that seems to unlock the potential of the mushroom. Either @ peak or after. The Traveler Euphoric Endlessness When DMT is smoked at the peak or post-peak of mushrooms, there is an extreme synergy that can make it for an incredible experience that can take one very very far! For some this is their favorite combo, for others not

DMT + LSD

DMT + LSD
Combination:	OK
Generic information:	...
User descriptions:	House Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak. The Traveler Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD. endlessness Same as above. For some people they feel its better to smoke at the comedown, or some people dont like it at all because they feel LSD acts as an anchor and holds one down, preventing breakthrough

DMT + MDMA

DMT + MDMA
Combination:	OK
Generic information:	...
User descriptions:	House Euphoric, not as deep of a trip, but there is zero anxiety present which can be useful and awesome in it's own right.

DMT + Mescaline

DMT + Mescaline
Combination:	OK But...
Generic information:	...
User descriptions:	House Great synergy here. Potentiates the mescaline and smooths it out. The Traveler The mescaline seems to 'dull' the DMT. So there was not as much effects from smoking the DMT on Mescaline as you would expect.

DMT + Alcohol

DMT + Alcohol
Combination:	SAFE But...
Generic information:	...
User descriptions:	House I find that combining the spice with a carcinogenic neurotoxin like alcohol completely negates the experience and masks it with toxic nullification (Yes, I am quite biased) The Traveler The alcohol did have a negative impact on me. I tried to drink a few beers beforehand to mitigate the anxiety of the pharmahuasca but that only resulted in dulling down, confusion and nausea. Dante The Spice doesn't like Alcohol, you'll either wont remember or get a bad vibe.

DMT + Cannabis

DMT + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House OK, although some people don't like it. If you are a daily cannabis smoker it shouldn't be a problem, but if you get anxiety from using Cannabis occasionally it may be wise not to mix it with DMT. Purges If I smoke DMT / Changa 1-2 hrs after my last hit of cannabis it is great, if I smoke DMT & Cannabis together it is not so great.

Harmalas (MAOI)

Side effects include contraindication with certain substances. Make sure you understand interactions with substances before using them! At higher doses users experience nausea and vomiting, but this also isn't necessarily a bad thing, since harmalas are anti-parasitic, purging is often considered cleansing to both the body and the mind. Chest pressure is also common with ayahuasca. Feelings of having something heavy sitting on you. This is normal and if experienced just relax and let it be, it's part of the serpents coil.

Harmalas (MAOI) + Caffeine

Harmalas + caffeine
Combination:	OK But...
Generic information:	...
User descriptions:	House I personally don't mind a low dose of harmalas on top of caffeine, it can counter act the sedation from the harmalas in the right dosages. Too much of both and you will experience uncomfortable heart rate. So new users to this synergy take caution and start low! gory dkalz I had one cup of average strength coffee about 2 hours after smoking changa and I got very edgy and nervous. Coffee barely even wakes me up but I was wired for about an hour. Quite uncomfortable. obliguhl For me, a cup of yerba matè plus ayahuasca equals awful experience. There seem to be some people who can't take caffeine and ayahuasca

Oral Harmalas (MAOI) + 5-MeO-DMT

Harmalas + 5-MeO-DMT
Combination:	OK But...
Generic information:	...
User descriptions:	rOm this could be hard on some metabolism, or dangerous, but IME, a great form of pharmahuasca, more nausea than with N,N-DMT, but also more euphorie. endlessness Harmalas will significantly increase potency of 5-MeO-DMT. 40-60mg harmaline + 10mg 5-MeO-DMT orally is equivalent to 30-35mg oral 5-MeO-DMT by itself or 10 mg intranasally (see Ott 2001 Note that 35mg by itself was not active dosage to shulgin but was for ott

Harmalas (MAOI) + Kava kava

Harmalas + Kava Kava
Combination:	BAD IDEA!
Generic information:	Hypertension, Serotonin Syndrome. Death can result out of this combination!
User descriptions:

Oral Harmalas (MAOI) + Opioids

Oral Harmalas (MAOI) + Opioids
Combination:	BAD IDEA!
Generic information:	Has the potential for adverse reactions, namely CNS excitation or depression (resulting in high or low blood pressure).
User descriptions:

Harmalas (MAOI) + Dissociatives

Harmalas (MAOI) + Dissociatives
Combination:	BAD IDEA!
Generic information:	Even though there are reports on the net of people combining MXE with harmalas, in the right dosages harmalas + dissociatives have the potential to cause cardiac arrest.
User descriptions:

Mushrooms (psilocybin)

I (House) think the most common side effect I hear about with shrooms is stomach discomfort. A lot of people don't know that you really are not supposed to consume any kind of raw mushroom. It's a rare case in the culinary and medicinal fields where raw mushrooms are told to be ingested. (I can think of a few exceptions, of course.) So for some ingesting the raw material can be very nauseating, myself included. Making a tea or the lemon tek is the way to go. By soaking raw mushrooms in lime juice, the citric acid literally cooks the mushrooms breaking down the cell walls. This is also known as a ceviche in the cooking world. Personally I just slip the shot of lime juice with the mushrooms in it back, it tastes good and I don't experience nausea this way. Some people filter out the mushroom material from the solution. Experiment. Taking too many mushrooms can lead to a feeling of being poisoned, but as far as I know no one has ever died from taking them on their own. Dose accordingly!

Mushrooms + Cannabis

Mushrooms + Cannabis
Combination:	Depends
Generic information:	...
User descriptions:	House I won't use mushrooms without cannabis; Noticeable synergy and eases any anxiety present. Some people who don't use cannabis often find that this combo causes paranoia.

Mushrooms + MDMA

Mushrooms + MDMA
Combination:	OK
Generic information:	...
User descriptions:	House OK. Profound synergy. Great for meditation and dance

Mushrooms + Harmalas (MAOI)

Mushrooms + Harmala (MAOI)
Combination:	SAFE But
Generic information:	...
User descriptions:	House I personally love the harmala + mushrooms synergy, but some have noted that the harmalas potentiate the mushrooms very much and have had rough trips! If you want to experiment with this combo, start low and work your way up!

Mushrooms + Alcohol

Mushrooms + Alcohol
Combination:	SAFE But
Generic information:	...
User descriptions:	Bedazzle Tends to dull the trip, slower than cocaine however. Also, people tend to get negative from this combo. One might hypothesize that alcohol tends to turn the trip in a darker direction. Dante Bad idea, high chances to end up puking and feeling miserable.

Mushrooms + Alcohol + Cocaine + MDMA

Mushrooms + Alcohol + Cocaine + MDMA
Combination:	BAD IDEA!
Generic information:	...
User descriptions:	Dante Bad bad idea. I took the MDMA, Coke and Alcohol at the end of a Shrooms trip. Anxiety and profound guilt were felt in my whole body

Mushrooms + Cocaine

Mushrooms + Cocaine
Combination:	SAFE But
Generic information:	...
User descriptions:	Bedazzle Tends to dull the trip, or even stop it dead in it's tracks.

LSD

LSD is a potent vasoconstricting substance. This means it causes an increase in blood pressure by tightening the blood vessels in the body. This can be countered with vasodilating substances. Some find that oral hash completely diminishes the vasoconstriction. I like using transdermal magnesium prior to a dose to also help with things like jaw tension. Also, conscious relaxation, deep breaths, and massage (even done by the self) can help curb tension experienced from the drug. If you feel over stimulated or uncomfortable, you probably need to "Flow", so to speak. Get up, stretch, dance around, laugh, have an orgasm, be creative, play a musical instrument, take a hot shower. Things like this help with getting energy flowing and making meditation easier. Eat a bit of fruit on the come-up if you feel some unease! Many people find cannabis greatly eases the transition, but of course not everybody.

LSD + DMT

LSD + DMT
Combination:	OK
Generic information:	...
User descriptions:	House Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak. The Traveler Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.

LSD + Ayahuasca + DMT

LSD + Ayahuasca +DMT
Combination:	OK
Generic information:	...
User descriptions:	House This is my favorite synergy of all time. First take the LSD, then take a comfortable dose of banisteriopsis caapi tea, then smoke as much DMT/Changa as you desire. Absolutely astonishing.

LSD + Mushrooms

LSD + Mushrooms
Combination:	Depends
Generic information:	...
User descriptions:	House A lot of people don't like this combination for some reason- both drugs are just so powerful they may not need to go together, with that said however some people like the combo and it is OK to take. endlessness Strong synergy with Psilocybe mushrooms. Dante I took the Mushrooms while coming down from the LSD and I didn't feel any effect whatsoever. (EDIT: You probably have to take lots of Shrooms to fight the tollerance) Shadowman-x I haven't experimented enough with this combination to say for sure. Only very small doses, and they were kind of hazy.

LSD + MDMA

LSD + MDMA
Combination:	OK
Generic information:	...
User descriptions:	House Classic Combo. Take at the same time or let the acid kick in then take the MDMA. Profound synergy! The Traveler The MDMA gives a euphoric effect to the LSD experience. ChaoticMethod MDMA and LSD together is one of the most amazing synergy in terms of dancefloor experience... Dante The only time I did it, I took the LSD a while after the MDMA. Everything was very smooth and shiny. Great dancing combo! Shadowman-x MDMA removes any negative experiences I feel with LSD. POWERFULLY beautiful combination! All aesthetics are increased 10x, music is beautiful and flowing, playing music is amazing, dancing is amazing. Cuddling, hugging, telling people you love them... yes, this is a winner.

LSD + MDAI

LSD + MDAI
Combination:	OK
Generic information:	...
User descriptions:	The Traveler The MDAI gives a euphoric effect to the LSD experience.

LSD + Mescaline

LSD + Mescaline
Combination:	OK
Generic information:	...
User descriptions:	House Nice synergy but it's hard to tell how each drug is affecting each other. A bit like LSD + MDMA but a deeper, so to speak.

LSD + Cannabis

LSD + Cannabis
Combination:	Depends
Generic information:	...
User descriptions:	House Cannabis vasodilates the vasoconstriction of LSD especially if taken orally. Potentiates and smooths out the trip. Great for daily smokers. Has been known to cause anxiety in those who don't use Cannabis too often. The Traveler I almost never use cannabis, I wanted to use the cannabis versus the stimulation of the LSD. It gave me more visuals but it also made me dizzy. Overall I did not like it. Universecannon Definitely has led to a bunch of paranoia at times (I'm prone to that with weed alone though) but if combined carefully it can be totally worth it although i never do it anymore (no lsd). If a large amount is smoked at the peak-especially if i have a low tolerance- then it can really catapult the experience into a sort of out of body type thing with full blown 3-d immerse visions, IME Dante It gives a bit of anxiety, although the effect of LSD is potentiated for a little while. Be aware, it's very hard to roll a spliff while tripping

LSD + Cannabis + Tobacco

LSD + Cannabis + Tobacco
Combination:	OK
Generic information:	...
User descriptions:	Shadowman-x I mostly smoke spliffs, but I find spliffs (a 50/50 mix of cannabis and tobacco) To be quite pleasant at all periods of the LSD comeup. Usually my physical form is quite shakey and or cold during the LSD comeup, and cannabis warms me up and calms down any tension or shakiness. Spliffs induce a deep trance state for me, very pleasant.

LSD + MXE

LSD + MXE
Combination:	Depends
Generic information:	...
User descriptions:	Aetherius Rimor Did 30mg of MXE in the 2nd hour of 2 hits. That's the only time I've not been at home and unable to verbalize/coordinate movement. Luckily that's what designated drivers are for! Won't combine them again. Definitely stronger effects than same dose of each independent of each other. The Traveler The MXE potentiates the LSD effects with more visuals but it also significantly alters motor function to the point of immobility at high doses. Pandora Radical and profound potentiation/synergy. 12+ hour trip and much longer to sleep. I really love the synergy of LSD+MXE but I'm the kind of person who naturally chills during a trip, so being pancaked by effects is just an extra plus for me.

LSD + Amphetamines

LSD + Amphetamines
Combination:	Depends
Generic information:	...
User descriptions:	ChaoticMethod Somewhat safe but...Makes the LSD less visual and a bit more difficult to handle mentally because of the stress caused by the stimulants. It can be an interesting mix if partying but I would try to avoid it if possible. At least try to get pharmaceutical grade stimulants and not dirty street pills.

LSD + Harmalas (MAOI)

LSD + Harmalas (MAOI)
Combination:	Depends
Generic information:	...
User descriptions:	House You MUST make sure you have pure LSD, however! You do not want to mix harmala (RIMA, MAOI) with an unknown drug laid on blotter. It's great taken with a dose or taken after the dose has kicked in, as the vasodilation of the harmala counters the vasoconstriction of the LSD. Enoon Super strong synergy, stronger than usual visuals, visions, OBE, but also nausea, imobility and substatial amount of apprehension endlessness Strong synergy/potentiation, first timers should take very small doses to see how they react and only raise gradually. Shadowman-x I must admit I'm a bit of a Harmala "fiend". I love them and I see no negative applications to them, pretty much, as long as you are physically safe. They potentiate the visuals of LSD, get rid of the shakes and nervousness, help me emotionally sort through things and make me warm and content and happy. This is a WINNING combination, especially with chocolate caffeine or spliffs. all very good in my books. Great for meditation, dancing, writing, drawing, or playing music.

LSD + Amanita Muscaria/Pantherina

LSD + Amanita Muscaria/Pantherina
Combination:	OK
Generic information:	...
User descriptions:	rOm Great synergy, tends to make the trip more challenging and more visionnary, more entheogenic also, but it is again harder than LSD on it's own.

LSD + Alcohol

LSD + Mescaline
Combination:	Depends
Generic information:	...
User descriptions:	House Doesn't make sense to me to combine a CNS depressant with the brilliant effects of LSD. Dante Great and jolly, but it makes the trip a bit blurry and less powerful. Don't over do it, your liver wont appreciate it!. Shadowman-x I don't enjoy alcohol in general, so I'm slightly bias. When I was younger (15-16) I would shotgun beers on LSD and that was quite nice, but any hard alcohol combined with LSD turns you into a flailing, falling idiot apologizing for making such a big mess.

LSD + GHB

LSD + GHB
Combination:	Depends
Generic information:	...
User descriptions:	Shadowman-x I don't have enough concrete experience with this combination, but I haven't experienced negative interactions the few times I have done them. the GHB is very warm and mellow, although a bit of nausea or headache or spinny-ness can occur at higher doses, if everything is kept moderate it is much more pleasant than alcohol, although not quite as pleasant as MDMA.

Mescaline

Mescaline is a phenethylamine that does not have an amphetamine group on the molecule, unlike MDMA. This allows it to be able to be used with harmalas without contraindication. A very gentle and long lasting psychedelic with great empathic and stimulating properties.

Mescaline + Caffeine

Mescaline + Caffeine
Combination:	OK
Generic information:	...
User descriptions:	House A great way to potentiate your mescaline dose is with caffeine, especially coffee. Yerba mate and other teas are good too. Even the days after a trip, a nice cup gets you right back in that lovely state-of-mind. Some may find this combo too stimulating, however. The coffee can also be used to get digestion flowing if you are having indigestion from the cactus.

Mescaline + Cannabis

Mescaline + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House Noticeable potentiation and takes the edge off the stimulation subsequently. These two go hand-in-hand if you are a regular cannabis user. If not, start low!

Mescaline + Harmalas (MAOI)

Mescaline + Harmala
Combination:	OK
Generic information:	...
User descriptions:	House No contraindication here. A nice synergy. The harmala takes away some of the stimulation of the mescaline and makes the experience more dreamy.

Mescaline + Alcohol

Mescaline + Alcohol
Combination:	Depends
Generic information:	...
User descriptions:	House You can drink a lot of alcohol on mescaline, but I don't see the point. Takes away from the profound effects of the psychedelic. Dante In high doses it's extremely confusing! Good chances to blackout and puke.

Mescaline + MDMA

Mescaline + MDMA
Combination:	OK
Generic information:	...
User descriptions:	Dante Nice combo, but it wasn't enough to understand its effects.

Iboga

Careful with this one! Much research and tests must be done before ingesting this substance. It is clinically proven to slow down a rhythm of the heart beat and has killed people because of this. A heart panel and EKG are common tests preformed before ingesting this substance. Please beware of this and do a lot of research before even considering this very profound medicine! Side effects include disorientation, immobility, nausea, in high doses for very long periods of time. Some people still can't drive a car 1 week after a flood dose, for example.

Iboga + LSD

Iboga + LSD
Combination:	OK
Generic information:	...
User descriptions:	House LSD becomes much more potent after Iboga and I would suggest taking it sometime between 1-7 days after taking a low dose of Iboga. For me I find that the LSD really puts the teachings of the Iboga into perspective. Be careful though, there is a definite potentiation. rOm very challenging in my experience so the LSD was probably very high (vial wash) with loads of noribogaine (2 grams RB every days for four to five days) in the system. I personnally wouldn't recommend it.

Iboga + Mushrooms

Iboga + Mushrooms
Combination:	OK
Generic information:	...
User descriptions:	House I find that psilocybe mushrooms are a really great synergy. They seem to kick in the Iboga about 3x as hard, so a low dose of both makes for a good journey. Euphoric, meditative, deep combination. Great for sorting things out in your life.

Iboga + Cannabis

Iboga + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House Great synergy with Iboga and cannabis. Noticeable potentiation. Also takes care of the intense nausea with higher doses of Iboga a bit. I believe this synergy is even used traditionally in some instances. rOm Iboga and canabis are great together, the iboga focus the train of thought from canabis while canabis relax the iboga (stimulant at low doses) experience.

Iboga + Harmalas (MAOI)

Iboga + Harmala
Combination:	Depends
Generic information:	...
User descriptions:	House While myself and others have found a low dose of harmala to be a nice synergy with Iboga, others have found the combination too intense. Start low and work your way up. rOm Iboga and harmalas must be treaten with caution though in low doses, it seems like a very good combo though questionnably safe (in regards of mixing RIMA and SSRI).

Iboga + Coffee

Iboga + Coffee
Combination:	Depends
Generic information:	...
User descriptions:	House I personally love a low dose of Iboga with a good cup of coffee, and cannabis. I find it stimulating both physically and with the clarity of mind. Some may find this too stimulating. Don't expect to sleep the night of taking this combo!

MDMA

The most common side effects of MDMA are jaw tension, feeling burnt-out the next day, and it's minimal amount of neurotoxicity. A lot of people "pre load" with substances that are neuroprotectant before, during, and after the experience. Neuroprotectants include cannabis, nootropics, vitamin C, 5-HTP, and others. Jaw tension can be countered again with transdermal magnesium, conscious relaxation, meditation and massage. As for feeling burnt-out, try to only redose a small amount one time or not at all. Constantly redosing can cause more burnout srensations. Also dosing too high. You might want to touch, hug, kiss, and tell how much you love everything around you, too.

Taking MDMA with MAOI and certain prescription medications can lead to seratonin syndrome and even death so plesse be careful!

MDMA + Harmalas (MAOI)

MDMA + Harmalas (MAOI)
Combination:	BAD IDEA!
Generic information:	Hypertension, Serotonin Syndrome. Death can result out of this combination!
User descriptions:

MDMA + Cannabis

MDMA + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House Great synergy with MDMA and cannabis. Smooths out the stimulation. Biologically speaking, the cannabis actually works as a neuroprotectant against the neurotoxicity of MDMA. They go hand-in-hand if you are a fan of cannabis! Dante Very nice, but you end up smoking way too much.

MDMA + LSD + Ketamine + Cannabis

MDMA + LSD + Ketamine + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	Purges Better than OK for me. Have had some of the best nights of my life with this cocktail.

MDMA + DMT + Ketamine

MDMA + DMT + Ketamine
Combination:	OK
Generic information:	...
User descriptions:	ChaoticMethod Out-of-this-world OEVisuals. The euphoria of the MDMA is present and the visual quality of the K synergizes with the DMT in a very strange way. I would suggest taking only small dosages with all of those three if you are to give this combo a try.

Ketamine

Ketamine + LSD

Ketamine + LSD
Combination:	OK
Generic information:	...
User descriptions:	House This is a pretty classic and noteable synergy that many people love. The K takes you very deep into yourself, and away from yourself at the same time. Purges OK. Similar to the 2CB combo, be careful, both of these drugs have a tendency to be a bit mind bending, and in combo, expect it to get wild! Shadowman-x LSD + Ketamine is definitely a strange combination. In my experience it lends itself to meditation because alot of the time the mind is too befuddled to properly draw a train of thought. I find this combination quite inarticulating, it's one of the few drug interactions that make me a bit of a "dumbass", and just puddle me on the floor. Lower doses of ketamine + lsd are good for dancing, higher doses, for trancing.

Ketamine + LSD + Cannabis

Ketamine + LSD + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House Love it! Purges OK. You will get lost in the deepest recesses of your mind for quite some time, I love comatose tripping, but it isn't for everyone.

Ketamine + Harmalas (MAOI)

Ketamine + Harmala
Combination:	BAD IDEA!
Generic information:	Harmalas are contraindicated with dissociatives, this means you do not want to combine them. At high doses the cardiovascular system can shut down.
User descriptions:	House Made the mistake of trying changa on top of LSD + K once and I will never do that again. Intense bronchial constriction and chest pain was noted.

Ketamine + Cannabis

Ketamine + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House I love coming back from the ketamine trance and smoking cannabis. Great for meditation and integration if you enjoy cannabis!

Ketamine + DMT

Ketamine + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House DMT on Ketamine is out of this world stellar. The dissociative properties of ketamine completely eliminate any anxiety present, and the two work together to take you deep into whatever it is that we are... endlessness Some people suggest ketamine may smooth the entry int tryptamine space and some report incredible experiences. Special care is needed with ketamine due to it's potentially addictive nature and due to being dissociative/anaesthetic and increased risks of physical accidents. Justin Case's best results have been reported when k dose is kept low and tryptamine dose is solid but not excessive.

Ketamine + LSD + DMT

Ketamine + LSD + DMT
Combination:	OK
Generic information:	...
User descriptions:	House Throwing DMT into the mix is just that much more powerful.

Ketamine + MDMA

Ketamine + MDMA
Combination:	OK
Generic information:	...
User descriptions:	Dante Some people love it, I don't. I don't like small bumps of K, so when I take it, it always end up taking over all the rest.

Ketamine + Alcohol

Ketamine + Alcohol
Combination:	Depends
Generic information:	...
User descriptions:	Dante I heard it's not very safe. I did it few times and the day after I always felt miserable.

Salvia Divinorum

Salvia + DMT

Salvia + DMT
Combination:	OK
Generic information:	...
User descriptions:	Mysmelf OK. can be extremely disturbing though or unbelievably profound and real.

Salvia + Changa + Cannabis

Salvia + Changa + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	Mysmelf This is probably my favorite mix. I've had some of my deepest experiences mixing these three including one with multiple breakthroughs one on top of the other cascading deeper with a new universe created and destroyed each time.

Salvia + Cannabis

Salvia + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	Mysmelf This is a very therapeutic anesthetic. This kills pain very well and leaves me in a dreamy visionary state without the mind warping dissociating effects that salvia has on its own. As long as you don't go heavy on the salvia! tigerstrike92 Good! Great way to take the edge off of the pre-flight anxiety for salvia, which can be pretty rough at times.

Salvia + DMT

Salvia + DMT
Combination:	OK
Generic information:	...
User descriptions:	endlessness Effects are dramatic but its not clear if there is synergy or more like additive effects.

RC's

2C-B

2C-B + Ketamine

2C-B + Ketamine
Combination:	Depends
Generic information:	...
User descriptions:	Purges Have seen 2 people lose the plot on this combo, so be careful. For me, it subdues the edginess of the phenethylamine buzz, while adding a trippy colourful edge to the Ketamine. Can get confusing, which I think was why people freaked out a bit.

MDMA + 2CB + K + Cannabis

MDMA + 2CB + K + Cannabis
Combination:	Depends
Generic information:	...
User descriptions:	Purges Similar to the above, moar euphoria, but again please be careful with dosages.

2C-I

2C-I + Cannabis

2C-I + Cannabis
Combination:	Depends
Generic information:	...
User descriptions:	Purges made me feel sick, smoking anything on 2CI wasn't nice.

MXE

MXE + Cannabis

MXE + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	Purges OK. deep, visual, introspective, make sure you don't have anything to do / people to entertain as chances are you will be lost in thought. Did experience a little muscle tremoring, but less than 2CI on its own.

5-MeO-DALT + MXE

5-MeO-DALT + MXE
Combination:	Depends
Generic information:	...
User descriptions:	gory dkalz While on ~50mg 5-MeO-DALT orally I did a little test bump of 15 mg MXE insufflated and within minutes felt my heart rate go up and felt very dizzy. Thought that I had finally done it and mixed the wrong stuff and I would have to go to the ER but it stopped escalating and I just waited it out.

25i-NBOMe

25i-NBOMe + Cannabis + DMT

25i-NBOMe + Cannabis + DMT
Combination:	OK
Generic information:	...
User descriptions:	billydgator Awesome! About 2.5 hours into an 25i nbome trip i took some small blasts of spice, brought me from ++ to ++++.

AM-2201

AM-2201 + MDMA

AM-2201 + MDMA
Combination:	OK
Generic information:	...
User descriptions:	Orion Nice high, feels good and very sedating, very happy and relaxed. But can be VERY hallucinogenic, only smoke a little! Bizarre and realistic and gory hallucinations (man with half a leg bleeding allover the place!) are possible, voices become distorted and merged and speak impossible ridiculous things. The hallucination is short lived.

MDAI

MDAI + DMT

MDAI + DMT
Combination:	OK
Generic information:	...
User descriptions:	Orion Vaporized hits of DMT seem harder to break through on, but the effect of the DMT seem prolonged. Strange visuals (small pinpoint kaleidoscope patters appear and dissappear), last for longer than the spice effects would last, by up to 25 minutes longer. Does not seem dangerous, but the fact it makes open eye visuals linger for so long is interesting...

Medicine

SSRI/SSRE

Harmalas (MAOI) + SSRI/SSRE

Harmalas (MAOI) + SSRI/SSRE
Combination:	BAD IDEA!
Generic information:	Hypertension, Serotonin Syndrome. Death can result out of this combination!
User descriptions:

MDMA + SSRI/SSRE

Harmalas (MAOI) + SSRI/SSRE
Combination:	BAD IDEA!
Generic information:	Hypertension, Serotonin Syndrome. Death can result out of this combination!
User descriptions:

Cannabis

Cannabis works as a potent anti-inflammatory and vasodilating medication. Those who use it often find that it goes well with almost every other drug, while those who seldom use it may find that when combined with psychedelic substances it can cause paranoia and uncomfortable potentiation. If you are unfamiliar with the ways cannabis synergizes with other substances, it is wise to start low and work your way up to a comfortable amount. Many find that oral cannabinoids act as a more potent vasodilator than smoked, making this a good option for countering the vasoconstriction of drugs like LSD and LSA. Many people also use cannabis to counter the nausea caused by other drugs.

Cannabis + Harmalas (MAOI)

Cannabis + Harmalas (MAOI)
Combination:	OK
Generic information:	...
User descriptions:	House Harmalas potentiate the effects of cannabis, adding a nice dreamy feel and tracers to the vision. Since they are both vasodilating compounds, some people experience headaches if combined in high doses.

Other

Nootropics/Piracetam/Aniracetam

Piracetam + Psychedelics/Amphetamines

Piracetam + Psychedelics/Amphetamines
Combination:	OK
Generic information:	...
User descriptions:	endlessness Trout notes that justin case, toad and others have reported substantial increase in potency of phenetylamines (such as MDMA, mescaline, amphetamines) and suggest dosage is halved. Possible potentiation of tryptamines too. There is very little data on the pharmacodynamics and toxicity of this mixture, so care is adviced, even though due to low toxicity of tryptamines and piracetam by itself, its possible the toxicity of mixture is also low.

LSD + Piracetam

LSD + Piracetam
Combination:	OK
Generic information:	...
User descriptions:	Shadowman-x I have been dosing piracetam daily for a few weeks now, and in that time I've done LSD twice. Definitely noticed that each time the piracetam VASTLY improves ability to articulate myself, ability to recall the trip and get into deeper meditative states. Piracetam also greatly helps my ability to write more clearly in my journals, improves my ability to play music and LSD enhances my musical creativity. All in all, very good combination.

Kava Kava

Kava Kava + DMT

Kava Kava + DMT
Combination:	OK
Generic information:	...
User descriptions:	House Kava kava is relaxing and aids in dissipating pre-flight anxiety. A warm cup is great after DMT insufflation or vaporization. There is a noticeable synergy between the two and no discomfort or side effects have been noted.

Kava Kava + LSD

Kava Kava + LSD
Combination:	OK
Generic information:	...
User descriptions:	House Kava Kava after the peak of LSD when it's wearing off is a great way to take the edge off and get some rest. It's very effective and enjoyable this way with no side effects noted.

Kava Kava + Cannabis

Kava Kava + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House Nice synergy. Very relaxing.

DXM

DXM + Cannabis

DXM + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	tigerstrike92 Good. Great way to up the psychedelic aspect of dex.

DXM + Tobacco

DXM + Tobacco
Combination:	OK
Generic information:	...
User descriptions:	tigerstrike92 Great. Dex really makes tobacco shine, brings out the best world of nicotiana.

DXM + NO2

DXM + NO2
Combination:	OK
Generic information:	...
User descriptions:	tigerstrike92 Very, Very intense. Too much for some people, but for others, euphoria.

DXM + HBWR (LSA)

DXM + HBWR(LSA)
Combination:	Depends
Generic information:	...
User descriptions:	tigerstrike92 It really increases the psychedelia of dex, brings some awesomely colorful visions, but be very careful. Not much is known about the interactions of these two. I would not go above 3 HBWR seeds in combo.

Chocolate/Theobromine

Theobromine, a methylated xanthine found in chocolate and yerba mate, is a stimulant and psychedelic potentiator.

Low doses combined with psychedelics causes noticeable potentiation and empathy. High doses have the potential to cause nausea and over stimulation, so start low and work up to a comfortable dose!

Theobromine + Caffeine

Theobromine + Caffeine
Combination:	OK
Generic information:	...
User descriptions:	House Aka The Mocha. Nice warm fuzzy sociable synergy.

Theobromine + Caffeine + Mescaline

Theobromine + Caffeine + Mescaline
Combination:	OK
Generic information:	...
User descriptions:	House OK. Definite potentiation and synergy.

Theobromine + Passionflower

Theobromine + Passion Flower
Combination:	OK
Generic information:	...
User descriptions:	House OK, but don't use a lot of theobromine. I have had psychedelic effects with this combination, but also intense nausea and bronchial-constriction at higher doses.

Theobromine + Harmalas (MAOI)

Theobromine + Harmalas (MAOI)
Combination:	OK
Generic information:	...
User descriptions:	House OK but do not use a lot of theobromine or harmala. A little goes a long way! Same thing goes here if you have a little too much of either theobromine or harmala expect nausea and vomiting. At appropriate doses however the synergy is very nice. Theobromine potentiates the harmalas and any psychedelics you take as well.

Theobromine + LSD

Theobromine + LSD
Combination:	OK
Generic information:	...
User descriptions:	House OK. Noticeable synergy and potentiation Shadowman-x I haven't experimented too heavily with eating cacao on LSD, but I usually eat one or two handfulls of raw cacao nibs. I found the stimulation synergistic, very good for walking or running through the forest. I found that the cacao gets rid of the "shivers" I experience from LSD and warms me from the inside.

Theobromine + Mushrooms

Theobromine + Mushrooms
Combination:	OK
Generic information:	...
User descriptions:	House OK. Noticeable synergy and potentiation

Kratom

Kratom + MXE

Kratom + MXE
Combination:	OK
Generic information:	...
User descriptions:	Pandora Effects: Like 10-15 mgs of Hydrocodone.

NO2

NO2 + DMT

NO2 + DMT
Combination:	OK
Generic information:	...
User descriptions:	endlessness When nitrous is inhaled immediately after dmt, its reported by some people to significantly enhance the experience.

NO2 + LSD

NO2 + LSD
Combination:	OK
Generic information:	...
User descriptions:	ChaoticMethod OK. Very powerful. Be prepared to lie down and be somewhat paralyzed, depending on dosage.

NO2 + Ketamine

NO2 + Ketamine
Combination:	OK
Generic information:	...
User descriptions:	ChaoticMethod Amazing visuals. Out of body experience, very comfortable but no contact at all with the body.

NO2 + Mushrooms

NO2 + Mushrooms
Combination:	OK
Generic information:	...
User descriptions:	Dante Amazing! For few minutes you are in a DMT like world. (I'd love to try LSD + NO2)

Alcohol (Ethanol)

DXM + Alcohol

DXM + Alcohol
Combination:	Safe but
Generic information:	...
User descriptions:	tigerstrike92 I have done this a few times and been safe, but I was very careful and spaced my drinks out. I have read horror reports of people drinking to much on dex, and puking for upwards of an hour or two.

Salvia + Alcohol

Salvia + Alcohol
Combination:	Depends
Generic information:	...
User descriptions:	tigerstrike92 Puke city.

MDMA + Alcohol

MDMA + Alcohol
Combination:	Safe but
Generic information:	...
User descriptions:	Bedazzle Another potential Show Stopper. The Alcohol really tends to lessen, dull, or end the effects of the mdma. Aside from that, there is the danger of dehydration--when you are rolling you should drink water. Dante Quite nice, but do not over do it! If you have been drinking too much, you'll be hit by a train when the MDMA comes down.

Bufotenine + Alcohol

Bufotenine + Alcohol
Combination:	Safe but
Generic information:	...
User descriptions:	Dante Not a good combo. The Bufotenin's nausea will probably make you puke and the Alcohol will diminish the Bufotenin visual effects.

Caffeine

Mushrooms + Caffeine

Mushrooms + Caffeine
Combination:	Depends
Generic information:	...
User descriptions:	obliguhl Not so good. Caffeine disturbs the mushroom flow.

LSD + Caffeine

LSD + Caffeine
Combination:	OK
Generic information:	...
User descriptions:	House I love coffee or yerba mate with LSD. Wonderful combo. Shadowman-x I'm a bit of a coffee / mate junkie, so I find the combination quite synergistic. Smoking a spliff and drinking coffee on LSD makes me feel like all is right in the world and I can sit in meditation and take a good 30 minutes to drink my coffee and have my smoke. It lends itself to visual enhancement and incredible tingling sensations in the body, which for some people could make them quite restless, but I enjoy meditation on stimulants.

Melatonin

Melatonin + Mushrooms + Harmala + Cannabis + Changa

Melatonin + Mushrooms + Harmala + Cannabis + Changa
Combination:	OK
Generic information:	...
User descriptions:	Universecannon 50-100mg melatonin (very meditative and harmala-esque for me. Combines well with others like a mind lube. A few hours later - lower dose of oral harmalas (preferably caapi) + mushrooms + smoked Cannabis + changa to top it off and push it all through. Amazing synergy. Need to balance the ratios accordingly though. You can leave out the melatonin if your not used to higher doses (they're not really that sleepy like the lower doses though, oddly). I prefer this combo after a day or to without sleep. Sleep deprivation is a powerful means of accessing altered states that's been used for thousands of years, like in the epic of Gilgamesh, for example. That's not for everyone though and works best with a raw, plant based diet.)

Benzos/Barbituates

Benzodiazepines can be reduce an agitated rough/unpleasant trip but are generally not recommended if other non-invasive supportive care-taking can be done, because these substances will dull the consciousness and might prevent the tripper from learning from the hard experience and integrating it.

Chlorpromazine + Psychedelics

Chlorpromazine + Psychedelics
Combination:	OK
Generic information:	...
User descriptions:	endlessness Chlorpromazine substantially diminishes the effects of DMT, LSD and other similar molecules (see Moore et al 1975, Shah & Hedden 1978

Links

• 'Known drug-interactions' Wiki page