Known substance-interactions and their effects

WARNING:

THIS THREAD IS STILL 'IN THE MAKING' AND CAN CONTAIN WRONG DATA! DO NOT USE THIS THREAD AS A DRUG-INTERACTION GUIDE YET!

Introduction

This article is about the interactions and effects of mixing different entheogens, both with each other and with medicine. Some combinations have a good synergy while others can be a DEADLY combination! Taking any substance carries a high responsibility, please read the WARNING section with great care!

Warning!

THIS THREAD IS STILL 'IN THE MAKING' AND CAN CONTAIN WRONG DATA! DO NOT USE THIS THREAD AS A DRUG-INTERACTION GUIDE YET!
THIS THREAD IS STILL 'IN THE MAKING' AND CAN CONTAIN WRONG DATA! DO NOT USE THIS THREAD AS A DRUG-INTERACTION GUIDE YET!

Even though the interactions of certain substances are described here, it is extremely important to be safe at all times! This article is only to give information about interactions and their effects, this article is NOT meant for advice on taking any combination!

Many interactions described here are subjective descriptions, so what is shown here is only an indication on how certain combinations can affect you and how safe they are. Many times those effects are dependent on dose (of each substance), route of administration, timeline of administration, set and setting, your mood, your physical health, your mental health and many other factors.

Psychedelics

DMT

DMT + Harmalas (MAOI)

DMT + Harmalas (MAOI)
Combination:	OK
Generic information:	Harmalas potentiate and prolong the effects of DMT, while at the same time it adds a slight psychedelic effect of it's own. For DMT to be orally active, a MAOI is mandatory.
User descriptions:	House Oral activation. Potentiation. Slowed-down effect. The two go hand in hand creating a perfect synergy.

DMT + Mushrooms (psilocybin)

DMT + Mushrooms (psilocybin)
Combination:	OK
Generic information:	...
User descriptions:	House Another profound synergy that seems to unlock the potential of the mushroom. Either @ peak or after. The Traveler Euphoric

DMT + LSD

DMT + LSD
Combination:	OK
Generic information:	...
User descriptions:	House Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak. The Traveler Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.

DMT + MDMA

DMT + MDMA
Combination:	OK
Generic information:	...
User descriptions:	House Euphoric, not as deep of a trip, but there is zero anxiety present which can be useful and awesome in it's own right.

DMT + Mescaline

DMT + Mescaline
Combination:	OK But...
Generic information:	...
User descriptions:	House Great synergy here. Potentiates the mescaline and smooths it out. The Traveler The mescaline seems to 'dull' the DMT. So there was not as much effects from smoking the DMT on Mescaline as you would expect.

DMT + Alcohol

DMT + Alcohol
Combination:	SAFE But...
Generic information:	...
User descriptions:	House I find that combining the spice with a carcinogenic neurotoxin like alcohol completely negates the experience and masks it with toxic nullification (Yes, I am quite biased) The Traveler The alcohol did have a negative impact on me. I tried to drink a few beers beforehand to mitigate the anxiety of the pharmahuasca but that only resulted in dulling down, confusion and nausea.

DMT + Cannabis

DMT + Cannabis
Combination:	OK
Generic information:	...
User descriptions:	House OK, although some people don't like it. If you are a daily cannabis smoker it shouldn't be a problem, but if you get anxiety from using THC occasionally it may be wise not to mix it with DMT.

LSD

LSD + DMT

LSD + DMT
Combination:	OK
Generic information:	...
User descriptions:	House Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak. The Traveler Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.

LSD + Mushrooms

LSD + Mushrooms
Combination:	Depends
Generic information:	...
User descriptions:	House A lot of people don't like this combination for some reason- both drugs are just so powerful they may not need to go together, with that said however some people like the combo and it is OK to take.

LSD + MDMA

LSD + MDMA
Combination:	OK
Generic information:	...
User descriptions:	House Classic Combo. Take at the same time or let the acid kick in then take the MDMA. Profound synergy! The Traveler The MDMA gives a euphoric effect to the LSD experience.

LSD + MDAI

LSD + MDAI
Combination:	OK
Generic information:	...
User descriptions:	The Traveler The MDAI gives a euphoric effect to the LSD experience.

LSD + Mescaline

LSD + Mescaline
Combination:	OK
Generic information:	...
User descriptions:	House Nice synergy but it's hard to tell how each drug is affecting each other. A bit like LSD + MDMA but a deeper, so to speak.

LSD + Cannabis

LSD + Cannabis
Combination:	Depends
Generic information:	...
User descriptions:	House THC vasodilates the vasoconstriction of LSD especially if taken orally. Potentiates and smooths out the trip. Great for daily smokers. Has been known to cause anxiety in those who don't use THC too often. The Traveler I almost never use cannabis, I wanted to use the cannabis versus the stimulation of the LSD. It gave me more visuals but it also made me dizzy. Overall I did not like it.

LSD + MXE

LSD + MXE
Combination:	Depends
Generic information:	...
User descriptions:	Aetherius Rimor Did 30mg of MXE in the 2nd hour of 2 hits. That's the only time I've not been at home and unable to verbalize/coordinate movement. Luckily that's what designated drivers are for! Won't combine them again. Definitely stronger effects than same dose of each independent of each other. The Traveler The MXE potentiates the LSD effects with more visuals but it also significantly alters motor function to the point of immobility at high doses. Pandora Radical and profound potentiation/synergy. 12+ hour trip and much longer to sleep. I really love the synergy of LSD+MXE but I'm the kind of person who naturally chills during a trip, so being pancaked by effects is just an extra plus for me.

LSD + Harmalas (MAOI)

LSD + Harmalas (MAOI)
Combination:	Depends
Generic information:	...
User descriptions:	House You MUST make sure you have pure LSD, however! You do not want to mix harmala (RIMA, MAOI) with an unknown drug laid on blotter. It's great taken with a dose or taken after the dose has kicked in, as the vasodilation of the harmala counters the vasoconstriction of the LSD. Enoon Super strong synergy, stronger than usual visuals, visions, OBE, but also nausea, imobility and substatial amount of apprehension

Other

MDMA

The most common side effects of MDMA are jaw tension, feeling burnt-out the next day, and it's minimal amount of neurotoxicity. A lot of people "pre load" with substances that are neuroprotectant before, during, and after the experience. Neuroprotectants include cannabis, nootropics, vitamin C, 5-HTP, and others. Jaw tension can be countered again with transdermal magnesium, conscious relaxation, meditation and massage. As for feeling burnt-out, try to only redose a small amount one time or not at all. Constantly redosing can cause more burnout srensations. Also dosing too high. You might want to touch, hug, kiss, and tell how much you love everything around you, too.

Taking MDMA with MAOI and certain prescription medications can lead to seratonin syndrome and even death so plesse be careful!

MDMA + Harmalas (MAOI)

MDMA + Harmalas (MAOI)
Combination:	BAD IDEA!
Generic information:	Hypertension, Serotonin Syndrome. Death can result out of this combination!
User descriptions:

Links

• 'Known drug-interactions' Wiki page