Difference between revisions of "Tetrahydroharmine"
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== Pharmacology, toxicity and general safety == | == Pharmacology, toxicity and general safety == | ||
| + | Thought to be metabolized similarly to other harmala alkaloids. | ||
| + | Toxicity thought to be similar to other harmala alkaloids i.e the LD50 of haamine is 243 mg/kg SC inmice models. | ||
| + | Like other harmala alkaloids thought to be unsafe with certain drugs, could potentially cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant, stimulants, common migraine medication, certain herbs, most cold medicine, opiates, nicotine and caffeine. | ||
| + | |||
| + | Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity. | ||
== Plants containing THH == | == Plants containing THH == | ||
Revision as of 09:07, 12 February 2023
Contents
Brief overview - What is THH?
Tetrahydroharmine (THH) is a fluorescent pyschoactive indole alkaloid. It occurs naturally in B. Caapi. Like other harmala alkaloids it is a RIMA reversible inhibitor of monoamine oxidase A. However, unlike harmine and harmaline, THH also inhibits reuptake of serotonin.
Chemical and physical properties
Formula:C13H16N2O
Molar mass:216.284 g·mol−1
Solubility:
DMF: 1.5 mg/ml
PBS (pH 7.2): 0.25 mg/ml
DMSO: 2 mg/ml
Ethanol: 1.5 mg/ml
Ethyl Acetate: unknown mg/ml
Melting point: Unknown
Effects
Pharmacology, toxicity and general safety
Thought to be metabolized similarly to other harmala alkaloids. Toxicity thought to be similar to other harmala alkaloids i.e the LD50 of haamine is 243 mg/kg SC inmice models. Like other harmala alkaloids thought to be unsafe with certain drugs, could potentially cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant, stimulants, common migraine medication, certain herbs, most cold medicine, opiates, nicotine and caffeine.
Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity.
Plants containing THH
Extraction teks
Dosages and consumption methods
History of usage
Analysis of THH
GC-MS
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