Difference between revisions of "Harmine"
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| + | == Brief overview - What is Harmine? == | ||
| + | |||
| + | == Chemical and physical properties == | ||
| + | |||
| + | 7-methoxy-β-carboline | ||
| + | |||
| + | === Freebase Harmine === | ||
| + | <table><tr><td>[[Image:harminefreebase.png]]</td><td></table> | ||
| + | * Composition: C13H12N2O | ||
| + | * Molecular Weight: 212.25 (Sigma Aldrich) | ||
| + | * Melting point: 262-264 °C (Sigma Aldrich) | ||
| + | * Boiling point: 421.4°Cat760mmHg ([http://www.lookchem.com/cas-442/442-51-3.html Lookchem]) | ||
| + | * XLogP: 2.5 | ||
| + | * XLogP3: 3.6 | ||
| + | * pKa: 7.7 | ||
| + | * Colorimetric reagent results: [https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=25771 Here] | ||
| + | * Solubility: | ||
| + | Insoluble in basic water, poorly soluble in distilled water. Reasonably soluble in acetone (at 25°C, acetone can dissolve 4mg/ml mixed harmalas as [https://www.dmt-nexus.com/forum/default.aspx?g=posts&m=200200#post200200 this test shows]) | ||
| + | * Isolation: To separate from harmaline, using pKa properties, raise pH of solution containing both alkaloids to pH 8.75 to precipitate 92% of harmine and only 8% Harmaline. Filter to retrieve precipitated alkaloids, and raise the pH further to retrieve the bulk of harmaline. Check the [https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=5725 freebase percentage calculator thread] and the [http://wiki.dmt-nexus.com/Harmalas_Extraction_and_Separation_Guide Harmala Extraction Guide] for more info. | ||
| + | |||
| + | === Harmine Hydrochloride === | ||
| + | <table><tr><td>[[Image:harminehcl.png]]</td><td></table> | ||
| + | * Melting Point: 321 °C | ||
| + | * Solubility: | ||
| + | Soluble in water | ||
| + | |||
| + | Insoluble in salt-saturated water | ||
| + | |||
| + | == Effects == | ||
| + | |||
| + | == Pharmacology, toxicity and general safety == | ||
| + | |||
| + | == Plants containing Harmine == | ||
| + | |||
| + | == Extraction teks == | ||
| + | |||
| + | == Dosages and consumption methods == | ||
| + | |||
| + | == History of usage == | ||
| + | |||
| + | == Analysis of Harmine == | ||
| + | |||
| + | == Scientific publications == | ||
| + | |||
| + | == Other links of interest == | ||
| + | |||
| + | {{Page Footer|Allies and Associated Alkaloids}} | ||
[[Category:Alkaloids]] | [[Category:Alkaloids]] | ||
Revision as of 13:21, 7 November 2011
Contents
Brief overview - What is Harmine?
Chemical and physical properties
7-methoxy-β-carboline
Freebase Harmine
 |
- Composition: C13H12N2O
- Molecular Weight: 212.25 (Sigma Aldrich)
- Melting point: 262-264 °C (Sigma Aldrich)
- Boiling point: 421.4°Cat760mmHg (Lookchem)
- XLogP: 2.5
- XLogP3: 3.6
- pKa: 7.7
- Colorimetric reagent results: Here
- Solubility:
Insoluble in basic water, poorly soluble in distilled water. Reasonably soluble in acetone (at 25°C, acetone can dissolve 4mg/ml mixed harmalas as this test shows)
- Isolation: To separate from harmaline, using pKa properties, raise pH of solution containing both alkaloids to pH 8.75 to precipitate 92% of harmine and only 8% Harmaline. Filter to retrieve precipitated alkaloids, and raise the pH further to retrieve the bulk of harmaline. Check the freebase percentage calculator thread and the Harmala Extraction Guide for more info.
Harmine Hydrochloride
 |
- Melting Point: 321 °C
- Solubility:
Soluble in water
Insoluble in salt-saturated water
