Difference between revisions of "Mescaline"

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== Chemical and physical properties ==
 
== Chemical and physical properties ==
  
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For solubility, melting point, etc, check the [[Psychedelic Compounds Chemical and Physical Properties#Mescaline|Mescaline Chemical and Physical Properties]] WIKI
  
3,4,5-trimethoxyphenethylamine
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== Effects ==
  
=== Freebase Mescaline ===
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Extremely long, slow comeup, lasting 2+ hoursNausea or purging for some, not for othersHigher doses can increase chances of purging, feeling of being poisoned and dizziness/difficulty standing/walking. Lower to mid doses could yield a feeling of nausea quickly followed by a "rolling" sense of euphoria.
<table><tr><td>[[Image:mescalinefreebase.png]]</td><td></table>
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* CAS Registry Number: 54-04-6
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* Composition: C11H17NO3
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* Melting point: 35-36°C (Kindler and Peschke, 103[http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
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* Boiling point: 180°C (12 mmHg)
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* XLogP: 0.6 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
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* XLogP3: 0.7 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4076&loc=ec_rcs PubChem])
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* pKa: 9.56
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* Appearance: long needle shaped white crystals
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* Molecular weight: 211.26
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Notes: forms mescaline carbonate on prolonged exposure to air
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* Average dose: 300 to 600 milligrams with a duration of 5 to 12 hours.
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* Colorimetric reagent results: [https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=25771 Here]
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* Solubility
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Soluble in: alcohol, chloroform, benzene, xylene, toluene, acetone, dichloromethane, highly soluble in isopropyl alcohol, soluble in d-limonene
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Moderately soluble in: water
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Trip is extremely long lasting - 10-14 hours plus.
  
Insoluble in: practically insoluble in ether or petroleum ether
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Color and music enhancement are exquisite.
* LD50: i.p. rats 370 mg/kg
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=== Mescaline Citrate ===
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Visuals are more organic looking than LSD.  More rounded corners, fewer sharp edges, in every sense of the term.  Colors are deeply and thoroughly saturated.
* Solubility
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Soluble in water
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Insoluble in: xylene, acetone <nowiki>*</nowiki>
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== Pharmacology, toxicity and general safety ==
  
<nowiki>*</nowiki> Possible unreliable web source.
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== Plants containing mescaline ==
  
=== Mescaline Hydrochloride ===
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== Extraction teks ==
<table><tr><td>[[Image:mescalinehcl.png]]</td><td></table>
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* Molecular weight: 247.72 (Sigma Aldrich)
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* Empirical Formula (Hill Notation): C11H17NO3 • HCl (Sigma Aldrich)
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* CAS Number: 832-92-8
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* Appearance: colorless crystals, needles
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* Melting point: 184°C ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
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* Solubility:
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Moderately soluble in: water, alcohol ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index]), methanol (at least 1.0 mg/ml, source Sigma Aldrich solution)
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(Merck Index)
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Insoluble in: practically insoluble in toluene and acetone, insoluble in isopropyl alcohol, diethyl ether, and d-limonene
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* LD50: i.p. rats 132 mg/kg
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* Storage temperature: 2-8°C (Sigma Aldrich)
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* Isolation: when mescaline hydrochloride is extracted from San Pedro, Achuma, or Peruvian torch, it can be isolated from the other alkaloids by washing it in IPA or acetone (use 10 ml per gram of alkaloids, and wash 2-3 times). The non-mescaline alkaloids dissolve in the IPA or acetate, while the mescaline hydrochloride does not. Note that for the cleanest results use about 2 washes of acetone, and then 2 washes with IPA.
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=== Mescaline Picrate ===
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== Dosages and consumption methods ==
* Melting point: mp 222°C.
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WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity.
  
=== Mescaline Sulfate Dihydrate ===
 
<table><tr><td>[[Image:mescalinesulfate.png]]</td><td></table>
 
* Composition: (C11H17NO3)2 • H2SO4 • 2H2O
 
* Appearance: prisms
 
* Melting point: 183–186 °C (361–367 °F)
 
* Molecular Weight: 309.33606
 
* Soluble in: hot water, methanol
 
* Almost insoluble in: near freezing water, alcohol, acetone <nowiki>*</nowiki>
 
<nowiki>*</nowiki> Possible unreliable web source.
 
  
=== Mescaline Fumarate ===
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Oral Dosage<ref>Mescaline Oral Dosage[https://m.psychonautwiki.org/wiki/Mescaline]</ref>:
* Composition: unknown (it may be a one to one salt or may not be)
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*Threshold 50 mg
* Appearance: White powder
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*Light 100 - 200 mg
* Melting point: unknown
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*Common 200 - 400 mg
* Solubility
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*Strong 400 - 800 mg
Soluble in: water
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*Heavy 800 mg+
  
Insoluble in: Limonene, Anydrous IPA, Acetone, MEK (most likely insoluble in all non-polars like xylene and toluene) [https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=18705 Source]
 
  
=== Mescaline Acetate ===
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Duration 8 - 12 hours:
* Composition: unknown
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*Onset 45 - 90 minutes
* Appearance: white free flowing powder with a slight waxy texture <nowiki>***</nowiki>
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*Come up 60 - 120 minutes
* Melting point: unknown
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*Peak 4 - 6 hours
* Solubility:
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*Comedown 2 - 3 hours
Soluble in: water<nowiki>***</nowiki>, isopropyl alcohol<nowiki>***</nowiki>, acetone<nowiki>***</nowiki>, DMSO<nowiki>***</nowiki> (more than 5 grams/100 ml), boiling MEK***
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Insoluble in: xylene, d-limonene, cold MEK (Methyl Ethyl Ketone) <nowiki>***</nowiki>
 
  
<nowiki>***</nowiki> This information was validated by SWIM and is reliable.
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After effects 6 - 36 hours
* Isolation: when mescaline acetate is extracted from San Pedro, Achuma, or Peruvian torch, it can be isolated from the other alkaloids by washing it in cold MEK (use 10 ml per gram of alkaloids, and wash 2-3 times). The non-mescaline alkaloids dissolve in the MEK, while the mescaline acetate does not. Mescaline acetate can be recrystallized in MEK by boiling the MEK and then freezing it overnight.
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== Effects ==
 
  
== Pharmacology, toxicity and general safety ==
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Mescaline is usually in a solid salt form. The type of salt can slightly affect dosage. In general the HCl salt is 90% stronger than other forms usually encountered.
  
== Plants containing mescaline ==
 
  
== Extraction teks ==
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Product needed to carry one millimol of mescaline:
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*Mescaline FB (reference, not encountered): 212mg
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*Mescaline HCl: 248mg
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*Mescaline Acetate: 271mg
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*Mescaline Citrate: 275mg
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*Mescaline Hydrogen Citrate: 307mg
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*Mescaline Dihydrogen Citrate: 402mg
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*Mescaline Malate: 278mg
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*Mescaline Sulfate Dihydrate: 278mg
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*Mescaline Bicarbonate (rare): 274mg†
  
== Dosages and consumption methods ==
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''†Bicarbonate form is assumed since carbonic acid's Pka2 > Mescaline's Pka''
  
 
== History of usage ==
 
== History of usage ==
  
 
== Analysis of Mescaline ==
 
== Analysis of Mescaline ==
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NMR 1H
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[[File:H1mesc.jpg]]
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GC-MS (EI)
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[[File:MescGCMS.jpg]]
  
 
== Scientific publications ==
 
== Scientific publications ==

Latest revision as of 11:32, 6 July 2021

Brief overview - What is Mescaline?

Chemical and physical properties

For solubility, melting point, etc, check the Mescaline Chemical and Physical Properties WIKI

Effects

Extremely long, slow comeup, lasting 2+ hours. Nausea or purging for some, not for others. Higher doses can increase chances of purging, feeling of being poisoned and dizziness/difficulty standing/walking. Lower to mid doses could yield a feeling of nausea quickly followed by a "rolling" sense of euphoria.

Trip is extremely long lasting - 10-14 hours plus.

Color and music enhancement are exquisite.

Visuals are more organic looking than LSD. More rounded corners, fewer sharp edges, in every sense of the term. Colors are deeply and thoroughly saturated.

Pharmacology, toxicity and general safety

Plants containing mescaline

Extraction teks

Dosages and consumption methods

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity.


Oral Dosage[1]:

  • Threshold 50 mg
  • Light 100 - 200 mg
  • Common 200 - 400 mg
  • Strong 400 - 800 mg
  • Heavy 800 mg+


Duration 8 - 12 hours:

  • Onset 45 - 90 minutes
  • Come up 60 - 120 minutes
  • Peak 4 - 6 hours
  • Comedown 2 - 3 hours


After effects 6 - 36 hours


Mescaline is usually in a solid salt form. The type of salt can slightly affect dosage. In general the HCl salt is 90% stronger than other forms usually encountered.


Product needed to carry one millimol of mescaline:

  • Mescaline FB (reference, not encountered): 212mg
  • Mescaline HCl: 248mg
  • Mescaline Acetate: 271mg
  • Mescaline Citrate: 275mg
  • Mescaline Hydrogen Citrate: 307mg
  • Mescaline Dihydrogen Citrate: 402mg
  • Mescaline Malate: 278mg
  • Mescaline Sulfate Dihydrate: 278mg
  • Mescaline Bicarbonate (rare): 274mg†


†Bicarbonate form is assumed since carbonic acid's Pka2 > Mescaline's Pka

History of usage

Analysis of Mescaline

NMR 1H

H1mesc.jpg


GC-MS (EI)

MescGCMS.jpg

Scientific publications

Other links of interest

  1. Mescaline Oral Dosage[1]