Difference between revisions of "Kash's A/B Mescaline Extraction"

Procedure for Mescaline HCl Extract
	1.		Begin by adding 100g cacti powder or diced 12in cacti cutting(s) to a pot. Add 30g citric acid. If using powder, add enough water to make it wet but not watery.
	2.		To this add 2L H2O and simmer for 2hrs. Any cacti snot will boil off eventually and the tea should become nonviscous and watery.
	3.		Filter out liquid from plant matter with a cloth filter and funnel, and add the liquid to another pot. Reduce this to a low volume by boiling. Add plant material back to original pot, cover with 2L H2O, and simmer for 1hr.
	4.		Repeat step 3 atleast four to six times total until the liquid filtered out has very little color. Discard plant material after final time and reduce all the aqueous cacti extract to around 500 ml. This can be put in a glass pickle jar.
	5.		Now it is time to basify. Mix 50g NaOH in 100ml H2O. It will get VERY hot, it is recommended to cool the mixing container while stirring with a cold water bath or under the faucet. Add the NaOH solution to the aqueous cacti extract.
	6.		Add 200ml toluene (or xylene) and mix for 10-15 minutes. Let the mixture settle and use a hot water bath to seperate the layers from the emulsion if necessary. The layers will seperate quickly. Seperate the layers with a pipet, separatory funnel, or syringe. Save the toluene in another glass container and put basic aqueous cacti solution back in original container.
	7.		Repeat previous step atleast 4 times total. Discard basic aqueous layer after, saving the toluene extract which contains the alkaloids.
	8.		To the toluene extract add 100ml H2O. Add 0.5ml concentrated HCl to this and mix well for 5 minutes. Check the pH. If it is still basic (pH 9+) then add incriments of 0.5ml HCl with mixing and checking pH until it tests acidic (below pH 7). Only one acid salting pull is necessary.
	9.		Seperate layers, hot water bath may be necessary to seperate emulsion quickly. Filter and save acidic H2O layer and discard/recycle toluene. Evaporate the aqueous layer on a dish with aid of a fan and/or hot water bath. Never use direct heat it will scorch your product. Scrape up the crystals.
	10.		Wash crystals with 50ml cold MEK (or anhydrous acetone, ethyl acetate). You will notice the solvent become discolored and the crystals become cleaner. Decant off the solvent carefully, leaving behind the cleaned crystals. -You will usually be left with light tan Mescaline HCl if pachanoi was used. Yield will be largely dependent on how efficiently you performed the extraction, but most importantly the quality of cacti used in the beginning. 0.5-1.5% yield of dry starting weight is average, but can range anywhere from 0-3%. Enjoy!

Procedure Notes

-Reducing the initial liquid: After each filtration the liquid is put into a pot, the "reducing pot". This can be boiled on high heat, just make sure it doesnt boil over. Once the liquid has boiled down to a low volume, stop reducing it when it becomes different in appearance and syrupy. Make sure not to reduce beyond this point and obviously dont boil it completely dry. Doing so will destroy alkaloids.

-Filtering plant material: This can be quite a frustrating step if working with cacti powder, though you get the hang of it over time. It is easiest to seperate out the liquid from cacti material by using cloth cut from a shirt and then pouring the sludge into a funnel through the cloth filter. Get a pair of rubber gloves and squeeze out the liquid from the filter. Dont squeeze too hard or cacti sludge will press through. Filtering is easiest to do while the liquid is hot and should be done atleast twice after each water boil. It also gets easier after each boil.

-Checking pH: The pH can be checked with pH paper by dipping it in the toluene/H2O solution while mixing. The paper must come in contact with the water layer as pH cannot be read from the nonpolar layer.

-Washing the crystals: It is important to wash your end crystals with a solvent like MEK or anhydrous acetone to remove impurities. The solvent dissolves resins and impurities, leaving behind cleaner non-sticky crystals.

Additional Purification

Procedure for White Mescaline NOTE Doesnt change effects much, but increases purity and looks awful pretty! This procedure can be used to obtain pure white mescaline, and solvent ratios must be followed exactly. Solvent ratio affects the rate crystals precipitate out and more importantly their size. If they are too small/precipitate too quickly, they will be too fine to filter or decant liquid from. More nonpolar-> decreases solubility, more methanol-> increases solubility.
	1.		To a glass container with 1g cleaned Mescaline Hcl add 50ml H2O + 1ml HCl. Mix well until crystals completely dissolve.
	2.		Add 50ml toluene.
	3.		Mix 10g NaOH with 50ml water and add this to the solution, turning it basic. Mix well for 10 minutes.
	4.		Seperate layers, saving toluene and discarding aqueous.
	5.		To another glass container pour 40ml methanol (HEET antifreeze remover) and add 0.5g fumaric acid. Mix well until fumaric acid dissolves.
	6.		Add the fumaric methanol to the toluene and mix it alittle. After a short time, the solution turns cloudy and crystals begin to form. Once crystals settle, mix it alittle more and pour into a dish.
	7.		Very carefully decant by pouring off liquid and leaving behind white crystals. With no remaining liquid on the plate, let crystals dry and scrape up, yielding pure white Mescaline Fumarate. Enjoy!

Additional Purification Notes

It is important to remove all the liquid to avoid fumaric acid contamination. Alternatively to decanting, you can filter if the crystals are big enough. This purification SWIM imagines could be used for 0-5g of mescaline before needing to change reagent amounts. It is also possible to use other solvent combinations and acids for precipitation, though this is left up to you. One could also get a pretty pure product if they simply did another hcl salting from the toluene instead of precipitation.