Difference between revisions of "Known substance-interactions and their effects"

House

Oral activation. Potentiation. Slowed-down effect. The two go hand in hand creating a perfect synergy.

House

Another profound synergy that seems to unlock the potential of the mushroom. Either @ peak or after.

The Traveler

Euphoric

Endlessness

When DMT is smoked at the peak or post-peak of mushrooms, there is an extreme synergy that can make it for an incredible experience that can take one very very far! For some this is their favorite combo, for others not

House

Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak.

The Traveler

Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.

endlessness

I didnt like it at all because it felt like LSD acts as an anchor and holds one down, preventing breakthrough

House

Euphoric, not as deep of a trip, but there is zero anxiety present which can be useful and awesome in it's own right.

House

Great synergy here. Potentiates the mescaline and smooths it out.

The Traveler

The mescaline seems to 'dull' the DMT. So there was not as much effects from smoking the DMT on Mescaline as you would expect.

Endlessness

The mescaline seemed to hold the DMT towards the center of the vision, as if it didnt let it "expand". I saw the DMT visuals curling up, like as if a magnetic/gravitational force didnt let it happen freely. The trip felt weird, it didnt feel 'natural' or 'flowing' to me. Tried it twice in different occasions to similar results and didnt feel like it's a good combination for me

House

I find that combining the spice with a carcinogenic neurotoxin like alcohol completely negates the experience and masks it with toxic nullification (Yes, I am quite biased)

The Traveler

The alcohol did have a negative impact on me. I tried to drink a few beers beforehand to mitigate the anxiety of the pharmahuasca but that only resulted in dulling down, confusion and nausea.

Dante

The Spice doesn't like Alcohol, you'll either wont remember or get a bad vibe.

House

OK, although some people don't like it. If you are a daily cannabis smoker it shouldn't be a problem, but if you get anxiety from using Cannabis occasionally it may be wise not to mix it with DMT.

Purges

If I smoke DMT / Changa 1-2 hrs after my last hit of cannabis it is great, if I smoke DMT & Cannabis together it is not so great.

Mindlusion

By far my absolute favourite combination. This experience is equal in intensity as DMT but without the ego loss. An entirely new realm all together where YOUR controller. This can mean many things, its sheer awesomeness with seemingly no downside gives it quite an addictive quality. During my first encounters with this combination I probably went through more DMT in one night then I normally would have in months, maybe a year.

House

I personally don't mind a low dose of harmalas on top of caffeine, it can counter act the sedation from the harmalas in the right dosages. Too much of both and you will experience uncomfortable heart rate. So new users to this synergy take caution and start low!

gory dkalz

I had one cup of average strength coffee about 2 hours after smoking changa and I got very edgy and nervous. Coffee barely even wakes me up but I was wired for about an hour. Quite uncomfortable.

obliguhl

For me, a cup of yerba matè plus ayahuasca equals awful experience. There seem to be some people who can't take caffeine and ayahuasca

rOm

this could be hard on some metabolism, or dangerous, but IME, a great form of pharmahuasca, more nausea than with N,N-DMT, but also more euphorie.

endlessness

Harmalas will significantly increase potency of 5-MeO-DMT. 40-60mg harmaline + 10mg 5-MeO-DMT orally is equivalent to 30-35mg oral 5-MeO-DMT by itself or 10 mg intranasally (see Ott 2001 Note that 35mg by itself was not active dosage to shulgin but was for ott

Picatris

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Corpus Callosm

taking levodopa with MAOIs runs the risk of a hypertensive crisis and levodopa should not be taken for at least 2 weeks after MAOIs; the risk of taking RIMAs (specifically moclobemide) with levodopa is one of increased side effects which include anorexia, nausea, vomiting, agitation, postural hypotension, tachycardia, arrythmias, hypomania, psychosis, depression, headache, flushing, gastrointestinal bleeding, itching, rashes, abnormal involuntary movements.

The thing to recognise about such advice is that some people may not suffer such adverse effects, but there is a significant likelihood of having such a response that it can only be considered wise to avoid such combinations

Corpus Callosm

l-tyrosine taken with MAOIs renders it more likely to be a vasopressor ie cause an elevation in BP.

The thing to recognise about such advice is that some people may not suffer such adverse effects, but there is a significant likelihood of having such a response that it can only be considered wise to avoid such combinationss

House

I won't use mushrooms without cannabis; Noticeable synergy and eases any anxiety present. Some people who don't use cannabis often find that this combo causes paranoia.

House

OK. Profound synergy. Great for meditation and dance

House

I personally love the harmala + mushrooms synergy, but some have noted that the harmalas potentiate the mushrooms very much and have had rough trips! If you want to experiment with this combo, start low and work your way up!

Mindlusion

I tried this combo at a fairly high dose, it GREATLY potentiated the effects.. And I absolutely loved it, quite more then the intensity I was looking for. Although after the first 6 hours, I felt the trip had come to conclusion, I was ecstatic, but physically and mentally exhausted, only to have the experience continue at practiaclly the same intensity for ANOTHER 6 hours. Before I could get any sleep whatsoever. If you try this combo, its great, just be prepared to trip for a LONG time.

Bedazzle

Tends to dull the trip, slower than cocaine however. Also, people tend to get negative from this combo. One might hypothesize that alcohol tends to turn the trip in a darker direction.

Dante

Bad idea, high chances to end up puking and feeling miserable.

Dante

Bad bad idea. I took the MDMA, Coke and Alcohol at the end of a Shrooms trip. Anxiety and profound guilt were felt in my whole body

Bedazzle

Tends to dull the trip, or even stop it dead in it's tracks.

House

Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak.

The Traveler

Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.

House

This is my favorite synergy of all time. First take the LSD, then take a comfortable dose of banisteriopsis caapi tea, then smoke as much DMT/Changa as you desire. Absolutely astonishing.

House

A lot of people don't like this combination for some reason- both drugs are just so powerful they may not need to go together, with that said however some people like the combo and it is OK to take.

endlessness

Strong synergy with Psilocybe mushrooms.

Dante

I took the Mushrooms while coming down from the LSD and I didn't feel any effect whatsoever. (EDIT: You probably have to take lots of Shrooms to fight the tollerance)

Shadowman-x

I haven't experimented enough with this combination to say for sure. Only very small doses, and they were kind of hazy.

House

Classic Combo. Take at the same time or let the acid kick in then take the MDMA. Profound synergy!

The Traveler

The MDMA gives a euphoric effect to the LSD experience.

ChaoticMethod

MDMA and LSD together is one of the most amazing synergy in terms of dancefloor experience...

Dante

The only time I did it, I took the LSD a while after the MDMA. Everything was very smooth and shiny. Great dancing combo!

Shadowman-x

MDMA removes any negative experiences I feel with LSD. POWERFULLY beautiful combination! All aesthetics are increased 10x, music is beautiful and flowing, playing music is amazing, dancing is amazing. Cuddling, hugging, telling people you love them... yes, this is a winner.

The Traveler

The MDAI gives a euphoric effect to the LSD experience.

House

Nice synergy but it's hard to tell how each drug is affecting each other. A bit like LSD + MDMA but a deeper, so to speak.

House

Cannabis vasodilates the vasoconstriction of LSD especially if taken orally. Potentiates and smooths out the trip. Great for daily smokers. Has been known to cause anxiety in those who don't use Cannabis too often.

The Traveler

I almost never use cannabis, I wanted to use the cannabis versus the stimulation of the LSD. It gave me more visuals but it also made me dizzy. Overall I did not like it.

Universecannon

Definitely has led to a bunch of paranoia at times (I'm prone to that with weed alone though) but if combined carefully it can be totally worth it although i never do it anymore (no lsd). If a large amount is smoked at the peak-especially if i have a low tolerance- then it can really catapult the experience into a sort of out of body type thing with full blown 3-d immerse visions, IME

Dante

It gives a bit of anxiety, although the effect of LSD is potentiated for a little while. Be aware, it's very hard to roll a spliff while tripping

Shadowman-x

I mostly smoke spliffs, but I find spliffs (a 50/50 mix of cannabis and tobacco) To be quite pleasant at all periods of the LSD comeup. Usually my physical form is quite shakey and or cold during the LSD comeup, and cannabis warms me up and calms down any tension or shakiness. Spliffs induce a deep trance state for me, very pleasant.

Aetherius Rimor

Did 30mg of MXE in the 2nd hour of 2 hits. That's the only time I've not been at home and unable to verbalize/coordinate movement. Luckily that's what designated drivers are for! Won't combine them again. Definitely stronger effects than same dose of each independent of each other.

The Traveler

The MXE potentiates the LSD effects with more visuals but it also significantly alters motor function to the point of immobility at high doses.

Pandora

Radical and profound potentiation/synergy. 12+ hour trip and much longer to sleep. I really love the synergy of LSD+MXE but I'm the kind of person who naturally chills during a trip, so being pancaked by effects is just an extra plus for me.

Mindlusion

I have tried this combination many times, but only at high doses of MXE, I loved this combination, it intensified and increased the depth and power of the dissociated 'hole' while making it easier to bring back more from the experience. The only negative effects Ive felt is the dissociated 'whobblies' that last for an hour or two after the hole, which can be annoying while trying walk around on LSD. In my experience, it is best taken early in the LSD trip, when the effects subside you are usually at the LSD peak, this also seems to ease any anxiety. (I would also like to mention I am quite mobile at high doses of MXE while on LSD, only after mobility can be hindered by the drunken like 'whobblies')

ChaoticMethod

Somewhat safe but...Makes the LSD less visual and a bit more difficult to handle mentally because of the stress caused by the stimulants. It can be an interesting mix if partying but I would try to avoid it if possible. At least try to get pharmaceutical grade stimulants and not dirty street pills.

House

You MUST make sure you have pure LSD, however! You do not want to mix harmala (RIMA, MAOI) with an unknown drug laid on blotter. It's great taken with a dose or taken after the dose has kicked in, as the vasodilation of the harmala counters the vasoconstriction of the LSD.

Enoon

Super strong synergy, stronger than usual visuals, visions, OBE, but also nausea, imobility and substatial amount of apprehension

endlessness

Strong synergy/potentiation, first timers should take very small doses to see how they react and only raise gradually.

Shadowman-x

I must admit I'm a bit of a Harmala "fiend". I love them and I see no negative applications to them, pretty much, as long as you are physically safe. They potentiate the visuals of LSD, get rid of the shakes and nervousness, help me emotionally sort through things and make me warm and content and happy. This is a WINNING combination, especially with chocolate caffeine or spliffs. all very good in my books. Great for meditation, dancing, writing, drawing, or playing music.

rOm

Great synergy, tends to make the trip more challenging and more visionnary, more entheogenic also, but it is again harder than LSD on it's own.

House

Doesn't make sense to me to combine a CNS depressant with the brilliant effects of LSD.

Dante

Great and jolly, but it makes the trip a bit blurry and less powerful. Don't over do it, your liver wont appreciate it!.

Shadowman-x

I don't enjoy alcohol in general, so I'm slightly bias. When I was younger (15-16) I would shotgun beers on LSD and that was quite nice, but any hard alcohol combined with LSD turns you into a flailing, falling idiot apologizing for making such a big mess.

Shadowman-x

I don't have enough concrete experience with this combination, but I haven't experienced negative interactions the few times I have done them. the GHB is very warm and mellow, although a bit of nausea or headache or spinny-ness can occur at higher doses, if everything is kept moderate it is much more pleasant than alcohol, although not quite as pleasant as MDMA.

House

A great way to potentiate your mescaline dose is with caffeine, especially coffee. Yerba mate and other teas are good too. Even the days after a trip, a nice cup gets you right back in that lovely state-of-mind. Some may find this combo too stimulating, however. The coffee can also be used to get digestion flowing if you are having indigestion from the cactus.

House

Noticeable potentiation and takes the edge off the stimulation subsequently. These two go hand-in-hand if you are a regular cannabis user. If not, start low!

House

No contraindication here. A nice synergy. The harmala takes away some of the stimulation of the mescaline and makes the experience more dreamy.

House

You can drink a lot of alcohol on mescaline, but I don't see the point. Takes away from the profound effects of the psychedelic.

Dante

In high doses it's extremely confusing! Good chances to blackout and puke.

Dante

Nice combo, but it wasn't enough to understand its effects.

House

LSD becomes much more potent after Iboga and I would suggest taking it sometime between 1-7 days after taking a low dose of Iboga. For me I find that the LSD really puts the teachings of the Iboga into perspective. Be careful though, there is a definite potentiation.

rOm

very challenging in my experience so the LSD was probably very high (vial wash) with loads of noribogaine (2 grams RB every days for four to five days) in the system. I personnally wouldn't recommend it.

House

I find that psilocybe mushrooms are a really great synergy. They seem to kick in the Iboga about 3x as hard, so a low dose of both makes for a good journey. Euphoric, meditative, deep combination. Great for sorting things out in your life.

House

Great synergy with Iboga and cannabis. Noticeable potentiation. Also takes care of the intense nausea with higher doses of Iboga a bit. I believe this synergy is even used traditionally in some instances.

rOm

Iboga and canabis are great together, the iboga focus the train of thought from canabis while canabis relax the iboga (stimulant at low doses) experience.

House

While myself and others have found a low dose of harmala to be a nice synergy with Iboga, others have found the combination too intense. Start low and work your way up.

rOm

Iboga and harmalas must be treaten with caution though in low doses, it seems like a very good combo though questionnably safe (in regards of mixing RIMA and SSRI).

House

I personally love a low dose of Iboga with a good cup of coffee, and cannabis. I find it stimulating both physically and with the clarity of mind. Some may find this too stimulating. Don't expect to sleep the night of taking this combo!

House

Great synergy with MDMA and cannabis. Smooths out the stimulation. Biologically speaking, the cannabis actually works as a neuroprotectant against the neurotoxicity of MDMA. They go hand-in-hand if you are a fan of cannabis!

Dante

Very nice, but you end up smoking way too much.

Purges

Better than OK for me. Have had some of the best nights of my life with this cocktail.

ChaoticMethod

Out-of-this-world OEVisuals. The euphoria of the MDMA is present and the visual quality of the K synergizes with the DMT in a very strange way. I would suggest taking only small dosages with all of those three if you are to give this combo a try.

House

This is a pretty classic and noteable synergy that many people love. The K takes you very deep into yourself, and away from yourself at the same time.

Purges

OK. Similar to the 2CB combo, be careful, both of these drugs have a tendency to be a bit mind bending, and in combo, expect it to get wild!

Shadowman-x

LSD + Ketamine is definitely a strange combination. In my experience it lends itself to meditation because alot of the time the mind is too befuddled to properly draw a train of thought. I find this combination quite inarticulating, it's one of the few drug interactions that make me a bit of a "dumbass", and just puddle me on the floor. Lower doses of ketamine + lsd are good for dancing, higher doses, for trancing.

House

Love it!

Purges

OK. You will get lost in the deepest recesses of your mind for quite some time, I love comatose tripping, but it isn't for everyone.

House

Made the mistake of trying changa on top of LSD + K once and I will never do that again. Intense bronchial constriction and chest pain was noted.

House

I love coming back from the ketamine trance and smoking cannabis. Great for meditation and integration if you enjoy cannabis!

House

DMT on Ketamine is out of this world stellar. The dissociative properties of ketamine completely eliminate any anxiety present, and the two work together to take you deep into whatever it is that we are...

endlessness

Some people suggest ketamine may smooth the entry int tryptamine space and some report incredible experiences. Special care is needed with ketamine due to it's potentially addictive nature and due to being dissociative/anaesthetic and increased risks of physical accidents. Justin Case's best results have been reported when k dose is kept low and tryptamine dose is solid but not excessive.

House

Throwing DMT into the mix is just that much more powerful.

Mindlusion

^ What House said.

Dante

Some people love it, I don't. I don't like small bumps of K, so when I take it, it always end up taking over all the rest.

Dante

I heard it's not very safe. I did it few times and the day after I always felt miserable.

Mysmelf

OK. can be extremely disturbing though or unbelievably profound and real.

Mysmelf

This is probably my favorite mix. I've had some of my deepest experiences mixing these three including one with multiple breakthroughs one on top of the other cascading deeper with a new universe created and destroyed each time.

Mysmelf

This is a very therapeutic anesthetic. This kills pain very well and leaves me in a dreamy visionary state without the mind warping dissociating effects that salvia has on its own. As long as you don't go heavy on the salvia!

tigerstrike92

Good! Great way to take the edge off of the pre-flight anxiety for salvia, which can be pretty rough at times.

endlessness

Effects are dramatic but its not clear if there is synergy or more like additive effects.

Purges

Have seen 2 people lose the plot on this combo, so be careful. For me, it subdues the edginess of the phenethylamine buzz, while adding a trippy colourful edge to the Ketamine. Can get confusing, which I think was why people freaked out a bit.

Purges

Similar to the above, moar euphoria, but again please be careful with dosages.

Purges

made me feel sick, smoking anything on 2CI wasn't nice.

Purges

OK. deep, visual, introspective, make sure you don't have anything to do / people to entertain as chances are you will be lost in thought. Did experience a little muscle tremoring, but less than 2CI on its own.

gory dkalz

While on ~50mg 5-MeO-DALT orally I did a little test bump of 15 mg MXE insufflated and within minutes felt my heart rate go up and felt very dizzy. Thought that I had finally done it and mixed the wrong stuff and I would have to go to the ER but it stopped escalating and I just waited it out.

billydgator

Awesome! About 2.5 hours into an 25i nbome trip i took some small blasts of spice, brought me from ++ to ++++.

Orion

Nice high, feels good and very sedating, very happy and relaxed. But can be VERY hallucinogenic, only smoke a little! Bizarre and realistic and gory hallucinations (man with half a leg bleeding allover the place!) are possible, voices become distorted and merged and speak impossible ridiculous things. The hallucination is short lived.

Orion

Vaporized hits of DMT seem harder to break through on, but the effect of the DMT seem prolonged. Strange visuals (small pinpoint kaleidoscope patters appear and dissappear), last for longer than the spice effects would last, by up to 25 minutes longer. Does not seem dangerous, but the fact it makes open eye visuals linger for so long is interesting...

House

Harmalas potentiate the effects of cannabis, adding a nice dreamy feel and tracers to the vision. Since they are both vasodilating compounds, some people experience headaches if combined in high doses.

endlessness

Trout notes that justin case, toad and others have reported substantial increase in potency of phenetylamines (such as MDMA, mescaline, amphetamines) and suggest dosage is halved. Possible potentiation of tryptamines too. There is very little data on the pharmacodynamics and toxicity of this mixture, so care is adviced, even though due to low toxicity of tryptamines and piracetam by itself, its possible the toxicity of mixture is also low.

Shadowman-x

I have been dosing piracetam daily for a few weeks now, and in that time I've done LSD twice. Definitely noticed that each time the piracetam VASTLY improves ability to articulate myself, ability to recall the trip and get into deeper meditative states. Piracetam also greatly helps my ability to write more clearly in my journals, improves my ability to play music and LSD enhances my musical creativity. All in all, very good combination.

Dream Weaver

I occasionally dose piracetam anywhere from 800mg to 4 grams ingested on an empty stomach (dissolved in water). I find the synergy of caffeine + piracetam to be quite soothing. It is important not to ingest too much caffeine or an anxiety like feeling will occur/stomach problems... Mostly positive if done right. Effects are very soothing and uplifting. Make the most mundane task entertaining. You become quick and sharp as a whip. Somewhat similar to 30mg xr adderall + 5-15mg valium. Great combo! Ideal for mornings!

House

Kava kava is relaxing and aids in dissipating pre-flight anxiety. A warm cup is great after DMT insufflation or vaporization. There is a noticeable synergy between the two and no discomfort or side effects have been noted.

House

Kava Kava after the peak of LSD when it's wearing off is a great way to take the edge off and get some rest. It's very effective and enjoyable this way with no side effects noted.

House

Nice synergy. Very relaxing.

tigerstrike92

Good. Great way to up the psychedelic aspect of dex.

tigerstrike92

Great. Dex really makes tobacco shine, brings out the best world of nicotiana.

tigerstrike92

Very, Very intense. Too much for some people, but for others, euphoria.

tigerstrike92

It really increases the psychedelia of dex, brings some awesomely colorful visions, but be very careful. Not much is known about the interactions of these two. I would not go above 3 HBWR seeds in combo.

Mindlusion

One of the most intense experiences I could possibly imagine. Classic Dissociative + DMT, but incomparable at the same time, I could say I like this combination better then DMT + Ketamine, or DMT + MXE, but its incomparable. It dissolves any preflight, or during anxiety whatsoever, the utterly intense godly power of DMT is given to YOU.

House

Aka The Mocha. Nice warm fuzzy sociable synergy.

House

OK. Definite potentiation and synergy.

House

OK, but don't use a lot of theobromine. I have had psychedelic effects with this combination, but also intense nausea and bronchial-constriction at higher doses.

House

OK but do not use a lot of theobromine or harmala. A little goes a long way! Same thing goes here if you have a little too much of either theobromine or harmala expect nausea and vomiting. At appropriate doses however the synergy is very nice. Theobromine potentiates the harmalas and any psychedelics you take as well.

House

OK. Noticeable synergy and potentiation

Shadowman-x

I haven't experimented too heavily with eating cacao on LSD, but I usually eat one or two handfulls of raw cacao nibs. I found the stimulation synergistic, very good for walking or running through the forest. I found that the cacao gets rid of the "shivers" I experience from LSD and warms me from the inside.

House

OK. Noticeable synergy and potentiation

Pandora

Effects: Like 10-15 mgs of Hydrocodone.

endlessness

When nitrous is inhaled immediately after dmt, its reported by some people to significantly enhance the experience.

ChaoticMethod

OK. Very powerful. Be prepared to lie down and be somewhat paralyzed, depending on dosage.

ChaoticMethod

Amazing visuals. Out of body experience, very comfortable but no contact at all with the body.

Dante

Amazing! For few minutes you are in a DMT like world. (I'd love to try LSD + NO2)

tigerstrike92

I have done this a few times and been safe, but I was very careful and spaced my drinks out. I have read horror reports of people drinking to much on dex, and puking for upwards of an hour or two.

tigerstrike92

Puke city.

Bedazzle

Another potential Show Stopper. The Alcohol really tends to lessen, dull, or end the effects of the mdma. Aside from that, there is the danger of dehydration--when you are rolling you should drink water.

Dante

Quite nice, but do not over do it! If you have been drinking too much, you'll be hit by a train when the MDMA comes down.

Dante

Not a good combo. The Bufotenin's nausea will probably make you puke and the Alcohol will diminish the Bufotenin visual effects.

obliguhl

Not so good. Caffeine disturbs the mushroom flow.

House

I love coffee or yerba mate with LSD. Wonderful combo.

Shadowman-x

I'm a bit of a coffee / mate junkie, so I find the combination quite synergistic. Smoking a spliff and drinking coffee on LSD makes me feel like all is right in the world and I can sit in meditation and take a good 30 minutes to drink my coffee and have my smoke. It lends itself to visual enhancement and incredible tingling sensations in the body, which for some people could make them quite restless, but I enjoy meditation on stimulants.

Universecannon

50-100mg melatonin (very meditative and harmala-esque for me. Combines well with others like a mind lube. A few hours later - lower dose of oral harmalas (preferably caapi) + mushrooms + smoked Cannabis + changa to top it off and push it all through. Amazing synergy. Need to balance the ratios accordingly though. You can leave out the melatonin if your not used to higher doses (they're not really that sleepy like the lower doses though, oddly). I prefer this combo after a day or to without sleep. Sleep deprivation is a powerful means of accessing altered states that's been used for thousands of years, like in the epic of Gilgamesh, for example. That's not for everyone though and works best with a raw, plant based diet.)

endlessness

Chlorpromazine substantially diminishes the effects of DMT, LSD and other similar molecules (see Moore et al 1975, Shah & Hedden 1978