Difference between revisions of "Known substance-interactions and their effects"

House

Oral activation. Potentiation. Slowed-down effect. The two go hand in hand creating a perfect synergy.

House

Another profound synergy that seems to unlock the potential of the mushroom. Either @ peak or after.

The Traveler

Euphoric

House

Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak.

The Traveler

Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.

House

Euphoric, not as deep of a trip, but there is zero anxiety present which can be useful and awesome in it's own right.

House

Great synergy here. Potentiates the mescaline and smooths it out.

The Traveler

The mescaline seems to 'dull' the DMT. So there was not as much effects from smoking the DMT on Mescaline as you would expect.

House

I find that combining the spice with a carcinogenic neurotoxin like alcohol completely negates the experience and masks it with toxic nullification (Yes, I am quite biased)

The Traveler

The alcohol did have a negative impact on me. I tried to drink a few beers beforehand to mitigate the anxiety of the pharmahuasca but that only resulted in dulling down, confusion and nausea.

House

OK, although some people don't like it. If you are a daily cannabis smoker it shouldn't be a problem, but if you get anxiety from using Cannabis occasionally it may be wise not to mix it with DMT.

Purges

If I smoke DMT / Changa 1-2 hrs after my last hit of cannabis it is great, if I smoke DMT & Cannabis together it is not so great.

House

I personally don't mind a low dose of harmalas on top of caffeine, it can counter act the sedation from the harmalas in the right dosages. Too much of both and you will experience uncomfortable heart rate. So new users to this synergy take caution and start low!

gory dkalz

I had one cup of average strength coffee about 2 hours after smoking changa and I got very edgy and nervous. Coffee barely even wakes me up but I was wired for about an hour. Quite uncomfortable.

obliguhl

For me, a cup of yerba matè plus ayahuasca equals awful experience. There seem to be some people who can't take caffeine and ayahuasca

House

I won't use mushrooms without cannabis; Noticeable synergy and eases any anxiety present. Some people who don't use cannabis often find that this combo causes paranoia.

House

OK. Profound synergy. Great for meditation and dance

House

I personally love the harmala + mushrooms synergy, but some have noted that the harmalas potentiate the mushrooms very much and have had rough trips! If you want to experiment with this combo, start low and work your way up!

Bedazzle

Tends to dull the trip, slower than cocaine however. Also, people tend to get negative from this combo. One might hypothesize that alcohol tends to turn the trip in a darker direction.

Bedazzle

Tends to dull the trip, or even stop it dead in it's tracks.

House

Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak.

The Traveler

Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.

House

This is my favorite synergy of all time. First take the LSD, then take a comfortable dose of banisteriopsis caapi tea, then smoke as much DMT/Changa as you desire. Absolutely astonishing.

House

A lot of people don't like this combination for some reason- both drugs are just so powerful they may not need to go together, with that said however some people like the combo and it is OK to take.

House

Classic Combo. Take at the same time or let the acid kick in then take the MDMA. Profound synergy!

The Traveler

The MDMA gives a euphoric effect to the LSD experience.

The Traveler

The MDAI gives a euphoric effect to the LSD experience.

House

Nice synergy but it's hard to tell how each drug is affecting each other. A bit like LSD + MDMA but a deeper, so to speak.

House

Cannabis vasodilates the vasoconstriction of LSD especially if taken orally. Potentiates and smooths out the trip. Great for daily smokers. Has been known to cause anxiety in those who don't use Cannabis too often.

The Traveler

I almost never use cannabis, I wanted to use the cannabis versus the stimulation of the LSD. It gave me more visuals but it also made me dizzy. Overall I did not like it.

Universecannon

Definitely has led to a bunch of paranoia at times (I'm prone to that with weed alone though) but if combined carefully it can be totally worth it although i never do it anymore (no lsd). If a large amount is smoked at the peak-especially if i have a low tolerance- then it can really catapult the experience into a sort of out of body type thing with full blown 3-d immerse visions, IME

Aetherius Rimor

Did 30mg of MXE in the 2nd hour of 2 hits. That's the only time I've not been at home and unable to verbalize/coordinate movement. Luckily that's what designated drivers are for! Won't combine them again. Definitely stronger effects than same dose of each independent of each other.

The Traveler

The MXE potentiates the LSD effects with more visuals but it also significantly alters motor function to the point of immobility at high doses.

Pandora

Radical and profound potentiation/synergy. 12+ hour trip and much longer to sleep. I really love the synergy of LSD+MXE but I'm the kind of person who naturally chills during a trip, so being pancaked by effects is just an extra plus for me.

House

You MUST make sure you have pure LSD, however! You do not want to mix harmala (RIMA, MAOI) with an unknown drug laid on blotter. It's great taken with a dose or taken after the dose has kicked in, as the vasodilation of the harmala counters the vasoconstriction of the LSD.

Enoon

Super strong synergy, stronger than usual visuals, visions, OBE, but also nausea, imobility and substatial amount of apprehension

House

A great way to potentiate your mescaline dose is with caffeine, especially coffee. Yerba mate and other teas are good too. Even the days after a trip, a nice cup gets you right back in that lovely state-of-mind. Some may find this combo too stimulating, however. The coffee can also be used to get digestion flowing if you are having indigestion from the cactus.

House

Noticeable potentiation and takes the edge off the stimulation subsequently. These two go hand-in-hand if you are a regular cannabis user. If not, start low!

House

No contraindication here. A nice synergy. The harmala takes away some of the stimulation of the mescaline and makes the experience more dreamy.

House

LSD becomes much more potent after Iboga and I would suggest taking it sometime between 1-7 days after taking a low dose of Iboga. For me I find that the LSD really puts the teachings of the Iboga into perspective. Be careful though, there is a definitely potentiation.

House

I find that psilocybe mushrooms are a really great synergy. They seem to kick in the Iboga about 3x as hard, so a low dose of both makes for a good journey. Euphoric, meditative, deep combination. Great for sorting things out in your life.

House

Great synergy with Iboga and cannabis. Noticeable potentiation. Also takes care of the intense nausea with higher doses of Iboga a bit. I believe this synergy is even used traditionally in some instances.

House

While myself and others have found a low dose of harmala to be a nice synergy with Iboga, others have found the combination too intense. Start low and work your way up.

House

I personally love a low dose of Iboga with a good cup of coffee, and cannabis. I find it stimulating both physically and with the clarity of mind. Some may find this too stimulating. Don't expect to sleep the night of taking this combo!

House

Great synergy with MDMA and cannabis. Smooths out the stimulation. Biologically speaking, the cannabis actually works as a neuroprotectant against the neurotoxicity of MDMA. They go hand-in-hand if you are a fan of cannabis!

Purges

Better than OK for me. Have had some of the best nights of my life with this cocktail.

House

This is a pretty classic and noteable synergy that many people love. The K takes you very deep into yourself, and away from yourself at the same time.

Purges

OK. Similar to the 2CB combo, be careful, both of these drugs have a tendency to be a bit mind bending, and in combo, expect it to get wild!

House

Love it!

Purges

OK. You will get lost in the deepest recesses of your mind for quite some time, I love comatose tripping, but it isn't for everyone.

House

Made the mistake of trying changa on top of LSD + K once and I will never do that again. Intense bronchial constriction and chest pain was noted.

House

I love coming back from the ketamine trance and smoking cannabis. Great for meditation and integration if you enjoy cannabis!

House

DMT on Ketamine is out of this world stellar. The dissociative properties of ketamine completely eliminate any anxiety present, and the two work together to take you deep into whatever it is that we are...

House

Throwing LSD into the mix is just that much more powerful.

Mysemelf

OK. can be extremely disturbing though or unbelievably profound and real.

Mysemelf

This is probably my favorite mix. I've had some of my deepest experiences mixing these three including one with multiple breakthroughs one on top of the other cascading deeper with a new universe created and destroyed each time.

Mysemelf

This is a very therapeutic anesthetic. This kills pain very well and leaves me in a dreamy visionary state without the mind warping dissociating effects that salvia has on its own. As long as you don't go heavy on the salvia!

tigerstrike92

Good! Great way to take the edge off of the pre-flight anxiety for salvia, which can be pretty rough at times.

Purges

Have seen 2 people lose the plot on this combo, so be careful. For me, it subdues the edginess of the phenethylamine buzz, while adding a trippy colourful edge to the Ketamine. Can get confusing, which I think was why people freaked out a bit.

Purges

Similar to the above, moar euphoria, but again please be careful with dosages.

Purges

made me feel sick, smoking anything on 2CI wasn't nice.

Purges

OK. deep, visual, introspective, make sure you don't have anything to do / people to entertain as chances are you will be lost in thought. Did experience a little muscle tremoring, but less than 2CI on its own.

gory dkalz

While on ~50mg 5-MeO-DALT orally I did a little test bump of 15 mg MXE insufflated and within minutes felt my heart rate go up and felt very dizzy. Thought that I had finally done it and mixed the wrong stuff and I would have to go to the ER but it stopped escalating and I just waited it out.

House

Kava kava is relaxing and aids in dissipating pre-flight anxiety. A warm cup is great after DMT insufflation or vaporization. There is a noticeable synergy between the two and no discomfort or side effects have been noted.

House

Kava Kava after the peak of LSD when it's wearing off is a great way to take the edge off and get some rest. It's very effective and enjoyable this way with no side effects noted.

House

Nice synergy. Very relaxing.

tigerstrike92

Good. Great way to up the psychedelic aspect of dex.

tigerstrike92

Great. Dex really makes tobacco shine, brings out the best world of nicotiana.

tigerstrike92

Very, Very intense. Too much for some people, but for others, euphoria.

tigerstrike92

It really increases the psychedelia of dex, brings some awesomely colorful visions, but be very careful. Not much is known about the interactions of these two. I would not go above 3 HBWR seeds in combo.

tigerstrike92

Aka The Mocha. Nice warm fuzzy sociable synergy.

tigerstrike92

OK. Definite potentiation and synergy.

tigerstrike92

OK, but don't use a lot of theobromine. I have had psychedelic effects with this combination, but also intense nausea and bronchial-constriction at higher doses.

tigerstrike92

OK but do not use a lot of theobromine or harmala. A little goes a long way! Same thing goes here if you have a little too much of either theobromine or harmala expect nausea and vomiting. At appropriate doses however the synergy is very nice. Theobromine potentiates the harmalas and any psychedelics you take as well.

tigerstrike92

OK. Noticeable synergy and potentiation

tigerstrike92

OK. Noticeable synergy and potentiation

tigerstrike92

I have done this a few times and been safe, but I was very careful and spaced my drinks out. I have read horror reports of people drinking to much on dex, and puking for upwards of an hour or two.

tigerstrike92

Puke city.

Bedazzle

Another potential Show Stopper. The Alcohol really tends to lessen, dull, or end the effects of the mdma. Aside from that, there is the danger of dehydration--when you are rolling you should drink water.

obliguhl

Not so good. Caffeine disturbs the mushroom flow.