Difference between revisions of "Known substance-interactions and their effects"

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==== Mushrooms + Harmala ====
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==== Mushrooms + Harmalas (MAOI)====
  
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{{SubstanceInteraction|Mushrooms + Harmala|#805000|#E0A040|SAFE But|...|
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{{SubstanceInteraction|Mushrooms + Harmala (MAOI)|#805000|#E0A040|SAFE But|...|
 
{{UserDescription|House|[[Image:Positive.png]]|I personally love the harmala + mushrooms synergy, but some have noted that the harmalas potentiate the mushrooms very much and have had rough trips! If you want to experiment with this combo, start low and work your way up!}}
 
{{UserDescription|House|[[Image:Positive.png]]|I personally love the harmala + mushrooms synergy, but some have noted that the harmalas potentiate the mushrooms very much and have had rough trips! If you want to experiment with this combo, start low and work your way up!}}
 
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==== Mescaline + Harmala ====
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==== Mescaline + Harmalas (MAOI) ====
  
 
{{SubstanceInteraction|Mescaline + Harmala|#406040|#60FF60|OK|...|
 
{{SubstanceInteraction|Mescaline + Harmala|#406040|#60FF60|OK|...|
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==== Iboga + Harmala ====
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==== Iboga + Harmalas (MAOI) ====
  
 
{{SubstanceInteraction|Iboga + Harmala|#805000|#E0A040|Depends|...|
 
{{SubstanceInteraction|Iboga + Harmala|#805000|#E0A040|Depends|...|
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==== Ketamine + Harmala ====
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==== Ketamine + Harmalas (MAOI) ====
  
 
{{SubstanceInteraction|Ketamine + Harmala|#604040|#FF6060|BAD IDEA!|Harmalas are contraindicated with dissociatives, this means you do not want to combine them. At high doses the cardiovascular system can shut down.|
 
{{SubstanceInteraction|Ketamine + Harmala|#604040|#FF6060|BAD IDEA!|Harmalas are contraindicated with dissociatives, this means you do not want to combine them. At high doses the cardiovascular system can shut down.|

Revision as of 23:30, 1 March 2012

Error.png WARNING: THIS THREAD IS STILL 'IN THE MAKING' AND CAN CONTAIN WRONG DATA! DO NOT USE THIS THREAD AS A DRUG-INTERACTION GUIDE YET!


Introduction

This article is about the interactions and effects of mixing different entheogens, both with each other and with medicine. Some combinations have a good synergy while others can be a DEADLY combination! Taking any substance carries a high responsibility, please read the WARNING section with great care!

Warning!

THIS THREAD IS STILL 'IN THE MAKING' AND CAN CONTAIN WRONG DATA! DO NOT USE THIS THREAD AS A DRUG-INTERACTION GUIDE YET!
THIS THREAD IS STILL 'IN THE MAKING' AND CAN CONTAIN WRONG DATA! DO NOT USE THIS THREAD AS A DRUG-INTERACTION GUIDE YET!

Even though the interactions of certain substances are described here, it is extremely important to be safe at all times! This article is only to give information about interactions and their effects, this article is NOT meant for advice on taking any combination!

Many interactions described here are subjective descriptions, so what is shown here is only an indication on how certain combinations can affect you and how safe they are. Many times those effects are dependent on dose (of each substance), route of administration, timeline of administration, set and setting, your mood, your physical health, your mental health and many other factors.

Psychedelics

DMT

Some report dysphoria at lower doses. I (House) do not find this to be the case I find low doses incredibly euphoric. Higher doses can be known to go beyond human emotions and concepts. Higher doses of DMT are also known to cause strange bodily hallucinations like the feeling that you have stopped breathing, or that your heart has stopped beating. These hallucinations are common and can be countered with conscious relaxation and meditation prior and during the experience. You do not have to submit, per se, but beware that you may have to let go of certain intensities during the experience. It can easily be the most "intense" experience of your life for some people, and this is *NOT* a bad thing!


DMT + Harmalas (MAOI)

DMT + Harmalas (MAOI) Information.png

Combination:

OK

Generic information:

Harmalas potentiate and prolong the effects of DMT, while at the same time it adds a slight psychedelic effect of it's own. For DMT to be orally active, a MAOI is mandatory.

User descriptions:

House

Positive.png

Oral activation. Potentiation. Slowed-down effect. The two go hand in hand creating a perfect synergy.


DMT + Mushrooms (psilocybin)

DMT + Mushrooms (psilocybin) Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

Another profound synergy that seems to unlock the potential of the mushroom. Either @ peak or after.

The Traveler

Positive.png

Euphoric


DMT + LSD

DMT + LSD Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak.

The Traveler

Positive.png

Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.


DMT + MDMA

DMT + MDMA Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

Euphoric, not as deep of a trip, but there is zero anxiety present which can be useful and awesome in it's own right.


DMT + Mescaline

DMT + Mescaline Information.png

Combination:

OK But...

Generic information:

...

User descriptions:

House

Positive.png

Great synergy here. Potentiates the mescaline and smooths it out.

The Traveler

Neutral.png

The mescaline seems to 'dull' the DMT. So there was not as much effects from smoking the DMT on Mescaline as you would expect.


DMT + Alcohol

DMT + Alcohol Information.png

Combination:

SAFE But...

Generic information:

...

User descriptions:

House

Negative.png

I find that combining the spice with a carcinogenic neurotoxin like alcohol completely negates the experience and masks it with toxic nullification (Yes, I am quite biased)

The Traveler

Negative.png

The alcohol did have a negative impact on me. I tried to drink a few beers beforehand to mitigate the anxiety of the pharmahuasca but that only resulted in dulling down, confusion and nausea.


DMT + Cannabis

DMT + Cannabis Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

OK, although some people don't like it. If you are a daily cannabis smoker it shouldn't be a problem, but if you get anxiety from using Cannabis occasionally it may be wise not to mix it with DMT.


Harmalas (MAOI)

Side effects include contraindication with certain substances. Make sure you understand interactions with substances before using them! At higher doses users experience nausea and vomiting, but this also isn't necessarily a bad thing, since harmalas are anti-parasitic, purging is often considered cleansing to both the body and the mind. Chest pressure is also common with ayahuasca. Feelings of having something heavy sitting on you. This is normal and if experienced just relax and let it be, it's part of the serpents coil.


Mushrooms (psilocybin)

I (House) think the most common side effect I hear about with shrooms is stomach discomfort. A lot of people don't know that you really are not supposed to consume any kind of raw mushroom. It's a rare case in the culinary and medicinal fields where raw mushrooms are told to be ingested. (I can think of a few exceptions, of course.) So for some ingesting the raw material can be very nauseating, myself included. Making a tea or the lemon tek is the way to go. By soaking raw mushrooms in lime juice, the citric acid literally cooks the mushrooms breaking down the cell walls. This is also known as a ceviche in the cooking world. Personally I just slip the shot of lime juice with the mushrooms in it back, it tastes good and I don't experience nausea this way. Some people filter out the mushroom material from the solution. Experiment. Taking too many mushrooms can lead to a feeling of being poisoned, but as far as I know no one has ever died from taking them on their own. Dose accordingly!


Mushrooms + Cannabis

Mushrooms + Cannabis Information.png

Combination:

Depends

Generic information:

...

User descriptions:

House

Positive.png

I won't use mushrooms without cannabis; Noticeable synergy and eases any anxiety present. Some people who don't use cannabis often find that this combo causes paranoia.


Mushrooms + MDMA

Mushrooms + MDMA Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

OK. Profound synergy. Great for meditation and dance


Mushrooms + Harmalas (MAOI)

Mushrooms + Harmala (MAOI) Information.png

Combination:

SAFE But

Generic information:

...

User descriptions:

House

Positive.png

I personally love the harmala + mushrooms synergy, but some have noted that the harmalas potentiate the mushrooms very much and have had rough trips! If you want to experiment with this combo, start low and work your way up!


Mushrooms + Alcohol

Mushrooms + Alcohol Information.png

Combination:

SAFE But

Generic information:

...

User descriptions:

Bedazzle

Negative.png

Tends to dull the trip, slower than cocain however. Also, people tend to get negative from this combo. One might hypothesize that alcohol tends to turn the trip in a darker direction.


LSD

LSD is a potent vasoconstricting substance. This means it causes an increase in blood pressure by tightening the blood vessels in the body. This can be countered with vasodilating substances. Some find that oral hash completely diminishes the vasoconstriction. I like using transdermal magnesium prior to a dose to also help with things like jaw tension. Also, conscious relaxation, deep breaths, and massage (even done by the self) can help curb tension experienced from the drug. If you feel over stimulated or uncomfortable, you probably need to "Flow", so to speak. Get up, stretch, dance around, laugh, have an orgasm, be creative, play a musical instrument, take a hot shower. Things like this help with getting energy flowing and making meditation easier. Eat a bit of fruit on the come-up if you feel some unease! Many people find cannabis greatly eases the transition, but of course not everybody.


LSD + DMT

LSD + DMT Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak.

The Traveler

Positive.png

Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.


LSD + Ayahuasca + DMT

LSD + Ayahuasca +DMT Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

This is my favorite synergy of all time. First take the LSD, then take a comfortable dose of banisteriopsis caapi tea, then smoke as much DMT/Changa as you desire. Absolutely astonishing.


LSD + Mushrooms

LSD + Mushrooms Information.png

Combination:

Depends

Generic information:

...

User descriptions:

House

Positive.png

A lot of people don't like this combination for some reason- both drugs are just so powerful they may not need to go together, with that said however some people like the combo and it is OK to take.


LSD + MDMA

LSD + MDMA Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

Classic Combo. Take at the same time or let the acid kick in then take the MDMA. Profound synergy!

The Traveler

Positive.png

The MDMA gives a euphoric effect to the LSD experience.


LSD + MDAI

LSD + MDAI Information.png

Combination:

OK

Generic information:

...

User descriptions:

The Traveler

Positive.png

The MDAI gives a euphoric effect to the LSD experience.


LSD + Mescaline

LSD + Mescaline Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

Nice synergy but it's hard to tell how each drug is affecting each other. A bit like LSD + MDMA but a deeper, so to speak.


LSD + Cannabis

LSD + Cannabis Information.png

Combination:

Depends

Generic information:

...

User descriptions:

House

Positive.png

Cannabis vasodilates the vasoconstriction of LSD especially if taken orally. Potentiates and smooths out the trip. Great for daily smokers. Has been known to cause anxiety in those who don't use Cannabis too often.

The Traveler

Negative.png

I almost never use cannabis, I wanted to use the cannabis versus the stimulation of the LSD. It gave me more visuals but it also made me dizzy. Overall I did not like it.


LSD + MXE

LSD + MXE Information.png

Combination:

Depends

Generic information:

...

User descriptions:

Aetherius Rimor

Negative.png

Did 30mg of MXE in the 2nd hour of 2 hits. That's the only time I've not been at home and unable to verbalize/coordinate movement. Luckily that's what designated drivers are for! Won't combine them again. Definitely stronger effects than same dose of each independent of each other.

The Traveler

Negative.png

The MXE potentiates the LSD effects with more visuals but it also significantly alters motor function to the point of immobility at high doses.

Pandora

Positive.png

Radical and profound potentiation/synergy. 12+ hour trip and much longer to sleep. I really love the synergy of LSD+MXE but I'm the kind of person who naturally chills during a trip, so being pancaked by effects is just an extra plus for me.


LSD + Harmalas (MAOI)

LSD + Harmalas (MAOI) Information.png

Combination:

Depends

Generic information:

...

User descriptions:

House

Positive.png

You MUST make sure you have pure LSD, however! You do not want to mix harmala (RIMA, MAOI) with an unknown drug laid on blotter. It's great taken with a dose or taken after the dose has kicked in, as the vasodilation of the harmala counters the vasoconstriction of the LSD.

Enoon

Neutral.png

Super strong synergy, stronger than usual visuals, visions, OBE, but also nausea, imobility and substatial amount of apprehension


Mescaline

Mescaline is a phenethylamine that does not have an amphetamine group on the molecule, unlike MDMA. This allows it to be able to be used with harmalas without contraindication. I (House) would describe it as ancient, wise, stimulating, dreamy, empathic, psychedelic, and long lasting. If there was a divine, this would be it. It is very forgiving in high doses unlike some of the other psychedelics in the kingdom. It is found as an insecticide in the cacti family, and has been shown to be produced in higher amounts by stressed species.


Mescaline + Caffeine

Mescaline + Caffeine Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

A great way to potentiate your mescaline dose is with caffeine, especially coffee. Yerba mate and other teas are good too. Even the days after a trip, a nice cup gets you right back in that lovely state-of-mind. Some may find this combo too stimulating, however. The coffee can also be used to get digestion flowing if you are having indigestion from the cactus.


Mescaline + Cannabis

Mescaline + Cannabis Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

Noticeable potentiation and takes the edge off the stimulation subsequently. These two go hand-in-hand if you are a regular cannabis user. If not, start low!


Mescaline + Harmalas (MAOI)

Mescaline + Harmala Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

No contraindication here. A nice synergy. The harmala takes away some of the stimulation of the mescaline and makes the experience more dreamy.


Iboga

Careful with this one! Much research and tests must be done before ingesting this substance. It is clinically proven to slow down a rhythm of the heart beat and has killed people because of this. A heart panel and EKG are common tests preformed before ingesting this substance. Please beware of this and do a lot of research before even considering this very profound medicine! Side effects include disorientation, immobility, nausea, in high doses for very long periods of time. Some people still can't drive a car 1 week after a flood dose, for example.


Iboga + LSD

Iboga + LSD Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

LSD becomes much more potent after Iboga and I would suggest taking it sometime between 1-7 days after taking a low dose of Iboga. For me I find that the LSD really puts the teachings of the Iboga into perspective. Be careful though, there is a definitely potentiation.


Iboga + Mushrooms

Iboga + Mushrooms Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

I find that psilocybe mushrooms are a really great synergy. They seem to kick in the Iboga about 3x as hard, so a low dose of both makes for a good journey. Euphoric, meditative, deep combination. Great for sorting things out in your life.


Iboga + Cannabis

Iboga + Cannabis Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

Great synergy with Iboga and cannabis. Noticeable potentiation. Also takes care of the intense nausea with higher doses of Iboga a bit. I believe this synergy is even used traditionally in some instances.


Iboga + Harmalas (MAOI)

Iboga + Harmala Information.png

Combination:

Depends

Generic information:

...

User descriptions:

House

Positive.png

While myself and others have found a low dose of harmala to be a nice synergy with Iboga, others have found the combination too intense. Start low and work your way up.


Iboga + Coffee

Iboga + Coffee Information.png

Combination:

Depends

Generic information:

...

User descriptions:

House

Positive.png

I personally love a low dose of Iboga with a good cup of coffee, and cannabis. I find it stimulating both physically and with the clarity of mind. Some may find this too stimulating. Don't expect to sleep the night of taking this combo!


MDMA

The most common side effects of MDMA are jaw tension, feeling burnt-out the next day, and it's minimal amount of neurotoxicity. A lot of people "pre load" with substances that are neuroprotectant before, during, and after the experience. Neuroprotectants include cannabis, nootropics, vitamin C, 5-HTP, and others. Jaw tension can be countered again with transdermal magnesium, conscious relaxation, meditation and massage. As for feeling burnt-out, try to only redose a small amount one time or not at all. Constantly redosing can cause more burnout srensations. Also dosing too high. You might want to touch, hug, kiss, and tell how much you love everything around you, too.

Taking MDMA with MAOI and certain prescription medications can lead to seratonin syndrome and even death so plesse be careful!


MDMA + Harmalas (MAOI)

MDMA + Harmalas (MAOI) Information.png

Combination:

BAD IDEA!

Generic information:

Hypertension, Serotonin Syndrome. Death can result out of this combination!

User descriptions:



MDMA + Cannabis

MDMA + Cannabis Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

Great synergy with MDMA and cannabis. Smooths out the stimulation. Biologically speaking, the cannabis actually works as a neuroprotectant against the neurotoxicity of MDMA. They go hand-in-hand if you are a fan of cannabis!


Ketamine

Ketamine + LSD

Ketamine + LSD Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

This is a pretty classic and noteable synergy that many people love. The K takes you very deep into yourself, and away from yourself at the same time.


Ketamine + Harmalas (MAOI)

Ketamine + Harmala Information.png

Combination:

BAD IDEA!

Generic information:

Harmalas are contraindicated with dissociatives, this means you do not want to combine them. At high doses the cardiovascular system can shut down.

User descriptions:

House

Negative.png

Made the mistake of trying changa on top of LSD + K once and I will never do that again. Intense bronchial constriction and chest pain was noted.


Ketamine + Cannabis

Ketamine + Cannabis Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

I love coming back from the ketamine trance and smoking cannabis. Great for meditation and integration if you enjoy cannabis!


Ketamine + DMT

Ketamine + Cannabis Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

DMT on Ketamine is out of this world stellar. The dissociative properties of ketamine completely eliminate any anxiety present, and the two work together to take you deep into whatever it is that we are...


Ketamine + LSD + DMT

Ketamine + LSD + DMT Information.png

Combination:

OK

Generic information:

...

User descriptions:

House

Positive.png

Throwing LSD into the mix is just that much more powerful.


RC's

2C-B

MDAI

MXE

Medicine

SSRI/SSRE

Other

Kava Kava

Cannabis

Alcohol (Ethanol)

Caffeine

Links

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