Difference between revisions of "Known substance-interactions and their effects"

House

I find that combining the spice with a carcinogenic neurotoxin like alcohol completely negates the experience and masks it with toxic nullification (Yes, I am quite biased)

The Traveler

The alcohol did have a negative impact on me. I tried to drink a few beers beforehand to mitigate the anxiety of the pharmahuasca but that only resulted in dulling down, confusion and nausea.

Dante

The Spice doesn't like Alcohol, you'll either wont remember or get a bad vibe.

Physics131

Depends on the dose. 1 Beer is ok and helps to reduce pre tripping fear. A bottle of wine before tripping is very uncomfortable and probably dangerous imo.

stoopkidpzpz

I took 1 MG of Xanax, and felt relaxed in about an hour. Decided to smoke some enhanced leaf... I smoked A LOT... I re-dosed for about 2 straight hours, 100mg doses each time. When I was finished I took another 1 MG of Xanax... A few hours later I became mildly confused, got a SEVERE headache, the worst I have ever had in my life. I had crippling nausea, could barely walk straight.. Ended up projectile vomiting multiple times until I fell asleep..

House

OK, although some people don't like it. If you are a daily cannabis smoker it shouldn't be a problem, but if you get anxiety from using Cannabis occasionally it may be wise not to mix it with DMT.

Purges

If I smoke DMT / Changa 1-2 hrs after my last hit of cannabis it is great, if I smoke DMT & Cannabis together it is not so great.

Entheogenerator

I always enjoyed DMT + cannabis when I was a daily cannabis smoker. At that time it worked to reduce anxiety and made it easier for me to relinquish control of the situation and allow the DMT to take over. Cannabis does not typically cause anxiety for me when it is used alone. But now that I only smoke cannabis on occasion (5-10 times a year), combining the two tends to cause a lot of anxiety and fear for me. I find that a puff or two of cannabis during the tail end of the DMT afterglow can help with integration, but I can no longer smoke cannabis prior to or at the same time as DMT.

Mindlusion

By far my absolute favourite combination. This experience is equal in intensity as DMT but without the ego loss. An entirely new realm all together where YOUR controller. This can mean many things, its sheer awesomeness with seemingly no downside gives it quite an addictive quality. During my first encounters with this combination I probably went through more DMT in one night then I normally would have in months, maybe a year.

House

Oral activation. Potentiation. Slowed-down effect. The two go hand in hand creating a perfect synergy.

House

Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak.

The Traveler

Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.

endlessness

I didnt like it at all because it felt like LSD acts as an anchor and holds one down, preventing breakthrough

House

Euphoric, not as deep of a trip, but there is zero anxiety present which can be useful and awesome in it's own right.

House

Great synergy here. Potentiates the mescaline and smooths it out.

The Traveler

The mescaline seems to 'dull' the DMT. So there was not as much effects from smoking the DMT on Mescaline as you would expect.

Endlessness

The mescaline seemed to hold the DMT towards the center of the vision, as if it didnt let it "expand". I saw the DMT visuals curling up, like as if a magnetic/gravitational force didnt let it happen freely. The trip felt weird, it didnt feel 'natural' or 'flowing' to me. Tried it twice in different occasions to similar results and didnt feel like it's a good combination for me

House

Another profound synergy that seems to unlock the potential of the mushroom. Either @ peak or after.

The Traveler

Euphoric

Endlessness

When DMT is smoked at the peak or post-peak of mushrooms, there is an extreme synergy that can make it for an incredible experience that can take one very very far! My favourite combo

Orion

Vaporized DMT whilst on mushrooms- Potentiation, intense synergy between the two tryptamines, very strong visuals came thick and fast.

Entheogenerator

I used DMT several times while on a daily Suboxone maintenance program, and the Suboxone did not have any noticeable effect on the DMT experience. I did not notice any difference between vaporized DMT with Suboxone and vaporized DMT without Suboxone. This may only apply to a person who is undergoing regular buprenorphine treatment and has developed a tolerance to the effects of buprenorphine to the point that it does not produce a "high". If a person without any tolerance to opiates/opioids were to take buprenorphine and then smoke/vaporize DMT, it may dull the effects of DMT to some extent as other opiates/opioids seem to.

House

I personally don't mind a low dose of harmalas on top of caffeine, it can counter act the sedation from the harmalas in the right dosages. Too much of both and you will experience uncomfortable heart rate. So new users to this synergy take caution and start low!

gory dkalz

I had one cup of average strength coffee about 2 hours after smoking changa and I got very edgy and nervous. Coffee barely even wakes me up but I was wired for about an hour. Quite uncomfortable.

obliguhl

For me, a cup of yerba matè plus ayahuasca equals awful experience. There seem to be some people who can't take caffeine and ayahuasca

rOm

this could be hard on some metabolism, or dangerous, but IME, a great form of pharmahuasca, more nausea than with N,N-DMT, but also more euphorie.

endlessness

Harmalas will significantly increase potency of 5-MeO-DMT. 40-60mg harmaline + 10mg 5-MeO-DMT orally is equivalent to 30-35mg oral 5-MeO-DMT by itself or 10 mg intranasally (see Ott 2001 Note that 35mg by itself was not active dosage to shulgin but was for ott

Picatris

Potentially unsafe combination and health risks due to metabolic issues. For more info search the forum for the thread titled "Does Anyone Here Eat 5-MEO-DMT?".

Corpus Callosm

taking levodopa with MAOIs runs the risk of a hypertensive crisis and levodopa should not be taken for at least 2 weeks after MAOIs; the risk of taking RIMAs (specifically moclobemide) with levodopa is one of increased side effects which include anorexia, nausea, vomiting, agitation, postural hypotension, tachycardia, arrythmias, hypomania, psychosis, depression, headache, flushing, gastrointestinal bleeding, itching, rashes, abnormal involuntary movements.

The thing to recognise about such advice is that some people may not suffer such adverse effects, but there is a significant likelihood of having such a response that it can only be considered wise to avoid such combinations

Corpus Callosm

l-tyrosine taken with MAOIs renders it more likely to be a vasopressor ie cause an elevation in BP.

The thing to recognise about such advice is that some people may not suffer such adverse effects, but there is a significant likelihood of having such a response that it can only be considered wise to avoid such combinationss

House

I won't use mushrooms without cannabis; Noticeable synergy and eases any anxiety present. Some people who don't use cannabis often find that this combo causes paranoia.

House

OK. Profound synergy. Great for meditation and dance

House

I personally love the harmala + mushrooms synergy, but some have noted that the harmalas potentiate the mushrooms very much and have had rough trips! If you want to experiment with this combo, start low and work your way up!

Mindlusion

I tried this combo at a fairly high dose, it GREATLY potentiated the effects.. And I absolutely loved it, quite more then the intensity I was looking for. The intensity gets tiresome on the tail-end when your exhausted and hoping to sleep. If you try this combo, its great, just be prepared to trip for a LONG time.

pitubo

Very interesting modification of the mushroom experience. Be careful to use only half or even less of your regular dose of mushrooms when combining with harmalas. Potentiation two- or threefold is to be expected even on moderate doses (100-125mg) of harmalas. Especially stronger doses of harmalas will intensify and prolong the mushroom trip far beyond what it would otherwise do. What I personally appreciate very much from this combination is the extended afterglow that keeps me in a special mood after the mushroom's effect wears out.

Bedazzle

Tends to dull the trip, slower than cocaine however. Also, people tend to get negative from this combo. One might hypothesize that alcohol tends to turn the trip in a darker direction.

Dante

Bad idea, high chances to end up puking and feeling miserable.

Frankycou

This is potentially very unsafe! some type of mushroom are known to develop poison when mixed with alcohol. This is very rough information that I am reporting since I don't remember the exact text and source but basically I read from a reputed source that some types are EXTREMLY BAD to mix and should be avoided at all cost.

Dante

Bad bad idea. I took the MDMA, Coke and Alcohol at the end of a Shrooms trip. Anxiety and profound guilt were felt in my whole body

Bedazzle

Tends to dull the trip, or even stop it dead in it's tracks.

House

Profound synergy. Really adds another more controlled layer to the hyperspatial flow. Highly recommended @ the peak or after the peak.

The Traveler

Euphoric, less anxiety. NOTE: For me it's best to take the DMT on the trail of the LSD and not on the peak of the LSD.

House

This is my favorite synergy of all time. First take the LSD, then take a comfortable dose of banisteriopsis caapi tea, then smoke as much DMT/Changa as you desire. Absolutely astonishing.

House

A lot of people don't like this combination for some reason- both drugs are just so powerful they may not need to go together, with that said however some people like the combo and it is OK to take.

endlessness

Strong synergy with Psilocybe mushrooms.

Dante

I took the Mushrooms while coming down from the LSD and I didn't feel any effect whatsoever. (EDIT: You probably have to take lots of Shrooms to fight the tollerance)

Shadowman-x

I haven't experimented enough with this combination to say for sure. Only very small doses, and they were kind of hazy.

Solar Garlic

This is one of my favorite combinations for tantric dance. I take around a gram of mushrooms right at peak. Fantastic synergy.

House

Classic Combo. Take at the same time or let the acid kick in then take the MDMA. Profound synergy!

The Traveler

The MDMA gives a euphoric effect to the LSD experience.

ChaoticMethod

MDMA and LSD together is one of the most amazing synergy in terms of dancefloor experience...

Dante

The only time I did it, I took the LSD a while after the MDMA. Everything was very smooth and shiny. Great dancing combo!

Shadowman-x

MDMA removes any negative experiences I feel with LSD. POWERFULLY beautiful combination! All aesthetics are increased 10x, music is beautiful and flowing, playing music is amazing, dancing is amazing. Cuddling, hugging, telling people you love them... yes, this is a winner.

The Traveler

The MDAI gives a euphoric effect to the LSD experience.

House

Nice synergy but it's hard to tell how each drug is affecting each other. A bit like LSD + MDMA but a deeper, so to speak.

House

Cannabis vasodilates the vasoconstriction of LSD especially if taken orally. Potentiates and smooths out the trip. Great for daily smokers. Has been known to cause anxiety in those who don't use Cannabis too often.

The Traveler

I almost never use cannabis, I wanted to use the cannabis versus the stimulation of the LSD. It gave me more visuals but it also made me dizzy. Overall I did not like it.

Universecannon

Definitely has led to a bunch of paranoia at times (I'm prone to that with weed alone though) but if combined carefully it can be totally worth it although i never do it anymore (no lsd). If a large amount is smoked at the peak-especially if i have a low tolerance- then it can really catapult the experience into a sort of out of body type thing with full blown 3-d immerse visions, IME

Dante

It gives a bit of anxiety, although the effect of LSD is potentiated for a little while. Be aware, it's very hard to roll a spliff while tripping

Poppyfire

Cannabis mellows out some of the more intense surges of body energy during the come-up of the LSD trip, which on their own can be unnerving at high doses. The combination of cannabis and LSD has been a favourite of mine for years, as the cannabis induces a calm state of mind, plus I personally don't enjoy taking LSD completely sober.

Shadowman-x

I mostly smoke spliffs, but I find spliffs (a 50/50 mix of cannabis and tobacco) To be quite pleasant at all periods of the LSD comeup. Usually my physical form is quite shakey and or cold during the LSD comeup, and cannabis warms me up and calms down any tension or shakiness. Spliffs induce a deep trance state for me, very pleasant.

Aetherius Rimor

Did 30mg of MXE in the 2nd hour of 2 hits. That's the only time I've not been at home and unable to verbalize/coordinate movement. Luckily that's what designated drivers are for! Won't combine them again. Definitely stronger effects than same dose of each independent of each other.

The Traveler

The MXE potentiates the LSD effects with more visuals but it also significantly alters motor function to the point of immobility at high doses.

Pandora

Radical and profound potentiation/synergy. 12+ hour trip and much longer to sleep. I really love the synergy of LSD+MXE but I'm the kind of person who naturally chills during a trip, so being pancaked by effects is just an extra plus for me.

Mindlusion