Difference between revisions of "Psilocin and Psilocybin"

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[[Image:psilocinfreebase.png|thumb|right|300px|''Psilocin Molecule'']]
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[[Image:psilocybin.png|thumb|right|300px|''Psilocybin Molecule'']]
 
== Brief overview - What is Psilocin / Psilocybin? ==
 
== Brief overview - What is Psilocin / Psilocybin? ==
  
== Chemical and physical properties ==
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Psilocin (4-Hydroxy-Dimethyltryptamine, or 4-HO-DMT), and Psilocybin (4-Phosphoryloxy-Dimethyltryptamine, or 4-PO-DMT) are the main active alkaloids in "magic mushrooms".
  
=== Psilocin ===
 
4-HO-DMT - 4-Hydroxy-N,N-dimethyl-tryptamine
 
  
==== Freebase Psilocin ====
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Some psychoactive mushrooms may have other active alkaloids such as [[Baeocystin]], and it is not really sure how different ratios of these alkaloids can affect the experience. Also certain mushrooms have been found with Phenetylamine, which though apparently inactive by itself, may be the reason for some tachycardia and other side-effects in some strains of psilocybin-containing mushrooms (ref Trout's Notes)
<table><tr><td>[[Image:psilocinfreebase.png]]</td><td></table>
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* CAS Registry Number:  520-53-6
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* Composition: C12H16N2O
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* Molecular Weight: 204.27 g/mol
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* Melting Point: 103-104°C ([http://isomerdesign.com/PiHKAL/read.php?domain=tk&id=18 TIHKAL]) , 173-176°C (Merck Index)
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* XLogP3: 2.1 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
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* Colorimetric reagent results: [https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=25771 Here]
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* Stability/Degradation: Unstable in solution, especially alkaline solution (Merck Index).
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* Solubility:
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Soluble in 70% ethanol. Poorly soluble in dry ethanol, and poorly soluble in ethanol less than 60%. Very slightly soluble in water (sources: [http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index] , [https://www.dmt-nexus.com/forum/default.aspx?g=posts&m=221711#post221711 scientific publications])
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=== Psilocybin ===
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There are other active mushrooms, such as Amanita muscaria and pantherina, which do not contain psilocin/psilocybin, but rather ibotenic acid/muscimol. These are completely different substances with different effects, not related to what is mentioned in this entry.
4-PO-DMT - O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine
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==== Psilocybin (Psilocin Phosphate Ester) ====
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== Chemical and physical properties ==
<table><tr><td>[[Image:psilocybin.png]]</td><td></table>
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* CAS Registry Number: 520-52-5
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For solubility, melting point, instabilities etc, check the [[Psychedelic Compounds Chemical and Physical Properties#Psilocybin|Psilocybin]]  and the [[Psychedelic Compounds Chemical and Physical Properties#Psilocin|Psilocin Chemical and Physical Properties]] WIKIs
* Composition: C12H17N2O4P
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* Molecular Weight: 284.248141 g/mol
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* Melting Point: 220-228° from boiling water; 185-195° from boiling methanol ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
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* XLogP3: -1.6 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10624&loc=ec_rcs PubChem])
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* Colorimetric reagent results: [https://www.dmt-nexus.me/forum/default.aspx?g=posts&t=25771 Here]
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* Stability/Degradation: Dephosphorylated into Psilocin under acidic conditions. Also when ingested, by phosphatases enzymes.
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* Solubility:
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Soluble in water. Soluble in 20 parts boiling water (= 0.79g/ml in boiling water), 120 parts boiling methanol (= 0.0932g/ml in boiling methanol); very soluble in 70% methanol saturated with KNO3, soluble in dry methanol, difficultly soluble in ethanol, increasingly less soluble in methanol less than 80%. Practically insoluble in chloroform, benzene (sources: [http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index] , [https://www.dmt-nexus.com/forum/default.aspx?g=posts&m=221711#post221711 scientific publications])
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== Effects ==
 
== Effects ==
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== Dosages and consumption methods ==
 
== Dosages and consumption methods ==
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Microdose .1-.4g of dried mushrooms Used for mental clarity and alleviation of depression and anxiety in daily life. Dosing every third day is the recommended frequency.
  
 
== History of usage ==
 
== History of usage ==
  
 
== Analysis of Psilocin / Psilocybin ==
 
== Analysis of Psilocin / Psilocybin ==
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http://www.anoniem.org/?http://www.justice.gov/dea/programs/forensicsci/microgram/journal_v4_num14/pg1.html
  
 
== Scientific publications ==
 
== Scientific publications ==

Latest revision as of 01:28, 6 October 2019

Psilocin Molecule
Psilocybin Molecule

Brief overview - What is Psilocin / Psilocybin?

Psilocin (4-Hydroxy-Dimethyltryptamine, or 4-HO-DMT), and Psilocybin (4-Phosphoryloxy-Dimethyltryptamine, or 4-PO-DMT) are the main active alkaloids in "magic mushrooms".


Some psychoactive mushrooms may have other active alkaloids such as Baeocystin, and it is not really sure how different ratios of these alkaloids can affect the experience. Also certain mushrooms have been found with Phenetylamine, which though apparently inactive by itself, may be the reason for some tachycardia and other side-effects in some strains of psilocybin-containing mushrooms (ref Trout's Notes)

There are other active mushrooms, such as Amanita muscaria and pantherina, which do not contain psilocin/psilocybin, but rather ibotenic acid/muscimol. These are completely different substances with different effects, not related to what is mentioned in this entry.

Chemical and physical properties

For solubility, melting point, instabilities etc, check the Psilocybin and the Psilocin Chemical and Physical Properties WIKIs

Effects

Pharmacology, toxicity and general safety

Mushrooms containing Psilocin / Psilocybin

Extraction teks

Dosages and consumption methods

Microdose .1-.4g of dried mushrooms Used for mental clarity and alleviation of depression and anxiety in daily life. Dosing every third day is the recommended frequency.

History of usage

Analysis of Psilocin / Psilocybin

http://www.anoniem.org/?http://www.justice.gov/dea/programs/forensicsci/microgram/journal_v4_num14/pg1.html

Scientific publications

Other links of interest