Tetrahydroharmine - Revision history

Trip: /* Pharmacology, toxicity and general safety */

2023-02-12T08:18:14Z

‎Pharmacology, toxicity and general safety

2023-02-12T08:18:02Z

‎Pharmacology, toxicity and general safety

2023-02-12T08:17:45Z

‎Pharmacology, toxicity and general safety

2023-02-12T08:17:13Z

‎Pharmacology, toxicity and general safety

2023-02-12T08:16:55Z

‎Pharmacology, toxicity and general safety

2023-02-12T08:13:55Z

‎History of usage

2023-02-12T08:12:39Z

‎Dosages and consumption methods

2023-02-12T08:09:44Z

‎Effects

2023-02-12T08:09:11Z

‎Plants containing THH

2023-02-12T08:08:56Z

‎Future Research

@@ Line 33: / Line 33: @@
 Like other harmala alkaloids, THH is thought to be unsafe with certain drugs; it could potentially cause serotonin syndrome or hypertensive crisis when combined with antidepressants, stimulants, common migraine medications, certain herbs, cold medication, opiates, nicotine and caffeine.
-Note: There is still not enough data available to confirm pharmacology pathways, interactions and toxicity.
+Note: There is still not enough data available to confirm pharmacology pathways, interactions and toxicity levels.
 == Plants containing THH ==

@@ Line 33: / Line 33: @@
 Like other harmala alkaloids, THH is thought to be unsafe with certain drugs; it could potentially cause serotonin syndrome or hypertensive crisis when combined with antidepressants, stimulants, common migraine medications, certain herbs, cold medication, opiates, nicotine and caffeine.
-Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity.
+Note: There is still not enough data available to confirm pharmacology pathways, interactions and toxicity.
 == Plants containing THH ==

@@ Line 31: / Line 31: @@
 Thought to be metabolized similarly to other harmala alkaloids.
 Toxicity thought to be similar to other harmala alkaloids i.e the LD50 of haamine is 243 mg/kg SC inmice models.
-Like other harmala alkaloids, THH is thought to be unsafe with certain drugs; it could potentially cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant, stimulants, common migraine medication, certain herbs, most cold medicine, opiates, nicotine and caffeine.
+Like other harmala alkaloids, THH is thought to be unsafe with certain drugs; it could potentially cause serotonin syndrome or hypertensive crisis when combined with antidepressants, stimulants, common migraine medications, certain herbs, cold medication, opiates, nicotine and caffeine.
 Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity.

@@ Line 31: / Line 31: @@
 Thought to be metabolized similarly to other harmala alkaloids.
 Toxicity thought to be similar to other harmala alkaloids i.e the LD50 of haamine is 243 mg/kg SC inmice models.
-Like other harmala alkaloids, THH is thought to be unsafe with certain drugs, could potentially cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant, stimulants, common migraine medication, certain herbs, most cold medicine, opiates, nicotine and caffeine.
+Like other harmala alkaloids, THH is thought to be unsafe with certain drugs; it could potentially cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant, stimulants, common migraine medication, certain herbs, most cold medicine, opiates, nicotine and caffeine.
 Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity.

@@ Line 31: / Line 31: @@
 Thought to be metabolized similarly to other harmala alkaloids.
 Toxicity thought to be similar to other harmala alkaloids i.e the LD50 of haamine is 243 mg/kg SC inmice models.
-Like other harmala alkaloids thought to be unsafe with certain drugs, could potentially cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant, stimulants, common migraine medication, certain herbs, most cold medicine, opiates, nicotine and caffeine.
+Like other harmala alkaloids, THH is thought to be unsafe with certain drugs, could potentially cause serotonin syndrome or hypertensive crisis when combined with almost any antidepressant, stimulants, common migraine medication, certain herbs, most cold medicine, opiates, nicotine and caffeine.
 Note: Not enough data available to confirm pharmacology pathways, interactions and toxicity.

← Older revision		Revision as of 08:13, 12 February 2023
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	== History of usage ==		== History of usage ==
		+	As it is found in B. Caapi, it has quite a historic and symbolistic use in traditional ayahuasca brews.

	== Analysis of THH ==		== Analysis of THH ==

← Older revision		Revision as of 08:12, 12 February 2023
Line 50:		Line 50:

	== Dosages and consumption methods ==		== Dosages and consumption methods ==
		+	Usually used in combination with harmine or other RIMA harmala alkaloids to create a synergistic effect. A usual adjunct to ayahuasca/ pharmahuasca. Can be used in other psychedelics combinations THH/ LSD, THH/ Psilocybin mushrooms etc.
		+
		+	Dose ranges 50-300mg.

	== History of usage ==		== History of usage ==

← Older revision		Revision as of 08:09, 12 February 2023
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	== Effects ==		== Effects ==
		+	Similar effects to other Harmala alkaloids

	== Pharmacology, toxicity and general safety ==		== Pharmacology, toxicity and general safety ==

← Older revision		Revision as of 08:08, 12 February 2023
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	Potential reduction pathways		Potential reduction pathways
		+
	[[File:4685 2b0909e8-9501-4209-b338-55bbad14ba59 harmaline oxidoreduction.jpg]]		[[File:4685 2b0909e8-9501-4209-b338-55bbad14ba59 harmaline oxidoreduction.jpg]]