Other ergolines - Revision history

Wallyslow: /* Other ergolines */

2014-03-11T12:56:22Z

‎Other ergolines

Wallyslow: /* Other ergolines */

2014-03-11T12:51:31Z

‎Other ergolines

Wallyslow at 12:44, 11 March 2014

2014-03-11T12:44:27Z

Wallyslow: /* Other ergolines */

2014-03-11T11:59:16Z

‎Other ergolines

Wallyslow: /* Other ergolines */

2014-03-11T11:33:21Z

‎Other ergolines

Wallyslow: /* Other ergolines */

2014-03-11T10:42:07Z

‎Other ergolines

Wallyslow: -other ergolines-

2014-03-11T10:39:00Z

-other ergolines-

New page

== Other ergolines ==

on the 8 position :

- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg.
source (J.ott in Pharmacotheon )
(it still unknown if these can cause gangreen / nercosis in certain people..)

-(s)Lasba : a(stereoseective butyl analoog op de 8-amide) has been found active in humans, but mostly act as a stimulant (perdue uni/nichols/personal exprience)
nice info to be found here : [http://bitnest.ca/Silo42/10.1007/BF02245940.pdf]

-also the morpholine and methyl-ethyl-amide moity are active (o.a hoffman/stoll and shulgin mentions it in Tihkal.)

promising :
- future research is being done to replace the carboxylic acid to a "thoiacid" (actually a thioeaster)
this means atthe top the top the oxygen might be repaced with a sulphur(=thio) and the still have the N-dimethyl...activity of these compound are still unknown.

- non-psychoactive ergolines :
bromocryptine, dihydroergotamine , dihydrolysergic, carbagoline and a bunch more , now used as proper migrane- an other-medicine.

on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.

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 == Other ergolines ==
-the ergot molecuul is pretty fragile  and decomposes easy in some Water/light/(some)air , the 3 best spots to change/improve the coumpound is at the most stable parts...those are the Nitrogens..in the moleculair ergot structur you see 3"N"'s , these are the nitrogens, one is at the bottom (position 1) , nr 2 is in the mid right position called position nr 6 and the third one is near the top connected to position 8 ( the positions are the number you get when you start counting the connections on the outside of the molecule anti-clockwise , try it !.
+the ergot molecuul is pretty fragile  and decomposes easy in some moist/light/(some)air , the 3 best spots to change/improve the coumpound stabilitiet is reanforce at the most stable parts...those are the Nitrogens..in the moleculair ergot structur you see 3"N"'s , these are the nitrogens, one is at the bottom (position 1) , nr 2 is in the mid right position called position nr 6 and the third one is near the top connected to position 8 ( the positions are the number you get when you start counting the connections on the outside of the molecule anti-clockwise , try it !.
-people have actually tried to add to the "N's possitions through extenting these nitrogen with carbons and such SD was hoffman 25th try for a new compound....but here are some lesser know other samples :
+people have tried to add more atoms /elements to the "N's possitions and one such experiment was hoffman 25th try for a new compound eventually known as lsd....but here are some lesser know other samples :
 )on the 8 position :

@@ Line 1: / Line 1: @@
 == Other ergolines ==
-the ergot molecuul is pretty fragile  and decomposes easy in some Water/light/(some)air , the 3 best spots to change/improve the coumpound is at the most stable parts...those are the Nitrogens..in the moleculair ergot structur you see 3"N"'s , these are the nitrogens, one is at the bottom (position 1) , nr 2 is in the mid right position called position nr 6 and the third one is near the top connected to position 8 ( the positions are the number yuo get wen you srt counting the connection on the outside of the molecule anti clockwise , try it !.
+the ergot molecuul is pretty fragile  and decomposes easy in some Water/light/(some)air , the 3 best spots to change/improve the coumpound is at the most stable parts...those are the Nitrogens..in the moleculair ergot structur you see 3"N"'s , these are the nitrogens, one is at the bottom (position 1) , nr 2 is in the mid right position called position nr 6 and the third one is near the top connected to position 8 ( the positions are the number you get when you start counting the connections on the outside of the molecule anti-clockwise , try it !.
-people have actually tried to change the "N's possitions through extenting these nitrogen the ergoline compounds lsd follow the same principle,
+people have actually tried to add to the "N's possitions through extenting these nitrogen with carbons and such SD was hoffman 25th try for a new compound....but here are some lesser know other samples :
 but here are some lesser know other samples :
-−
 )on the 8 position :

@@ Line 1: / Line 1: @@
 == Other ergolines ==
 )on the 8 position :
-- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg. it still unknown if these can cause gangreen / nercosis in certain people.
+- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1-4 mg. it still unknown if these can cause gangreen / nercosis in certain people.
 source (J.ott in Pharmacotheon )
--(S)Lasba : a stereoseective butyl analoog on the 8-amide has been found active in humans, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience)
+-(S)Lasba : a stereoselective butyl analoog on the 8-amide has been found active in humans a few years ago, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience)
 nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url]
@@ Line 28: / Line 33: @@
-- and then there is the sub-family called the clavines, which sems to have less medicinal properties therefor the main rearch woldwide is focused on the ergot-family.
+- and then there is the sub-family called the clavines who mostly have only 2 nitrogens in their structures which seems to have less medicinal properties and is sleightly less stabiel, therefor the main rearch woldwide is focused on the ergot-family.

← Older revision		Revision as of 11:59, 11 March 2014
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−	- and then there is the sub-family called the clavines, ~~but~~ the main rearch ~~focus~~ is on the ~~ergots~~.	+	- and then there is the sub-family called the clavines, which sems to have less medicinal properties therefor the main rearch woldwide is focused on the ergot-family.

@@ Line 1: / Line 1: @@
 == Other ergolines ==
-on the 8 position :
+)on the 8 position :
-- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg.
+- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg. it still unknown if these can cause gangreen / nercosis in certain people.
 source (J.ott in Pharmacotheon )
--(s)Lasba : a(stereoseective butyl analoog on the 8-amide) has been found active in humans, but mostly act as a stimulant (perdue uni/nichols/personal exprience)
-nice info to be found here : [http://bitnest.ca/Silo42/10.1007/BF02245940.pdf]
+-(S)Lasba : a stereoseective butyl analoog on the 8-amide has been found active in humans, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience)
 -also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)
 promising :
-- future research is being done to replace the carboxylic acid to a "thoiacid" (actually a thioeaster)
+- future research is being done to replace the carboxylic acid to a "thoiacid"
- this means at the top the oxygen will be repaced with a sulphur(=thio) and then still have room for the   N-diethyl amide. (activity of these compound are still unknown.)
+this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the  N-diethyl amide.
 - non-psychoactive ergolines :
-  bromocryptine, dihydroergotamine , dihydrolysergic, carbagoline and a bunch more , now used as proper migrane- an other-medicine.
+bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more,
-on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.