1P-LSD - Revision history

GameComplete at 07:42, 24 February 2015

2015-02-24T07:42:12Z

2015-02-24T07:38:21Z

2015-02-24T07:33:07Z

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2015-02-24T07:29:25Z

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 [[Image:1P-LSD.png|right|thumb|200px|1P-LSD]]
 * Systematic (IUPAC) name: (6aR,9R)-4-propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
+* Synonym: 1-Propionyl-lysergic acid diethylamide
 ----

@@ Line 3: / Line 3: @@
 * Psychedelic
+|
-* Open and closed eye visuals, euphoria, change in perception of time. Anecdotal report of being indistinguishable from LSD.
+* Anecdotal report of being indistinguishable from LSD.<ref>[http://www.bluelight.org/vb/threads/745848-The-Big-amp-Dandy-1P-LSD-%281-propionyl-lysergic-acid-diethylamide%29-Thread bluelight.org: The Big & Dandy 1P-LSD (1-propionyl-lysergic acid diethylamide) Thread]</ref>
+|
 * Possible side effects: nausea, [https://en.wikipedia.org/wiki/Vasoconstriction vasoconstriction], unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing

@@ Line 14: / Line 14: @@
 * This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use caution when working with this substance, a calibrated milligram scale and liquid measurement are vital.
 * Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}
+== Chemical and physical properties ==
 [[Image:1P-LSD.png|right|thumb|200px|1P-LSD]]
 * Systematic (IUPAC) name: (6aR,9R)-4-propionyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
-== Chemical and physical properties ==
+----
 From an old Wikipedia draft:<ref>https://en.wikipedia.org/w/index.php?title=Draft:1P-LSD&oldid=647406505</ref><br />
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 ''"I am sure that the 1-propionyl would also hydrolyze off of an indole, but I don't know whether in vivo conditions would work.  In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too.  But in the body?  I don't know the answer to that.  The compound would not be active as the N-propionyl however.  Way that LSD docks into the 5-HT2A receptor, the indole NH hydrogen bonds to serine 5.46.  With the propionyl, it won't fit into the receptor."<ref>http://www.shroomery.org/forums/showflat.php/Number/21106929#21106929</ref>''
-<!--== Effects ==
+<!--== Brief overview - What is 1P-LSD? ==
 == Pharmacology, toxicity and general safety ==

@@ Line 12: / Line 12: @@
 * 1P-LSD is a research chemical not mentioned in academic literature. The LD50 (median lethal dose) or long term / pharmacological / behavioral risks are not known.
 * 1P-LSD is likely a controlled substance analogue under US law if intended for human consumption.
-* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are vital.
+* This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use caution when working with this substance, a calibrated milligram scale and liquid measurement are vital.
 * Do not ingest 1P-LSD when your mental or physical health is poor. Observe the [https://en.wikipedia.org/wiki/Set_and_setting set and setting].}}

@@ Line 22: / Line 22: @@
 == Chemical and physical properties ==
 From an old Wikipedia draft:<ref>https://en.wikipedia.org/w/index.php?title=Draft:1P-LSD&oldid=647406505</ref><br />
-"I am sure that the 1-[[propionyl]] would also hydrolyze off of an [[indole]], but I don't know whether in vivo conditions would work.  In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too.  But in the body?  I don't know the answer to that.  The compound would not be active as the N-propionyl however.  Way that LSD docks into the [[5-HT2A receptor]], the indole NH hydrogen bonds to serine 5.46.  With the propionyl, it won't fit into the receptor."<ref>http://www.shroomery.org/forums/showflat.php/Number/21106929#21106929</ref>
+''Sharing a strong structural similarity with ALD-52, the chemical purportedly used in the 1960's Orange Sunshine 1P-LSD follows the less common path of modifying the 1- position on the LSD molecule which in the past has been avoided due to unpredictable results or lack of activity.<ref>http://chemistry.mdma.ch/hiveboard/palladium/pdf/Ergot%20-%20The%20Genus%20Claviceps%20(1999)/TF3168ch8.pdf</ref>
 <!--== Effects ==

@@ Line 10: / Line 10: @@
 * No other known specific physical risks at this time.
+|
-* 1P-LSD is a substance not mentioned in academic literature, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known.
+* 1P-LSD is a research chemical not mentioned in academic literature. The LD50 (median lethal dose) or long term / pharmacological / behavioral risks are not known.
-* No studies on this substance have been performed, so long term effects and potential risks are UNKNOWN!
 * 1P-LSD is probably a controlled substance analogue under US law if intended for human consumption.
 * This chemical is active in the [https://en.wikipedia.org/wiki/Microgram microgram (µg)] range. Please use extreme caution if working with this substance, a calibrated milligram scale and liquid measurement are vital.

@@ Line 5: / Line 5: @@
 * Open and closed eye visuals, euphoria, change in perception of time. Anecdotal report of being indistinguishable from LSD.
+|
-* Possible side effects: nausea, vasoconstriction (mostly when combined with other vasoconstricting substances like LSD), unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing
+* Possible side effects: nausea, [https://en.wikipedia.org/wiki/Vasoconstriction vasoconstriction], unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing
+|
 * Possible mental side effects: paranoia, fear, and panic. Hallucinogen persisting perception disorder.
@@ Line 12: / Line 12: @@
 * 1P-LSD is a substance not mentioned in academic literature, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known.
 * No studies on this substance have been performed, so long term effects and potential risks are UNKNOWN!
-* 1P-LSD is probably a controlled substance analogue under US law if intended for human consumption.}}
+* 1P-LSD is probably a controlled substance analogue under US law if intended for human consumption.
 [[Image:1P-LSD.png|right|thumb|200px|1P-LSD]]
@@ Line 43: / Line 45: @@
 == References ==
 <references />
-{{Page Footer|Allies and Associated Alkaloids}}
-[[Category:Alkaloids]]
+[[Category:Research Chemicals]]