DMT-Nexus Wiki - User contributions [en]

Other ergolines

2014-03-11T12:56:22Z

Wallyslow: /* Other ergolines */

== Other ergolines ==

the ergot molecuul is pretty fragile and decomposes easy in some moist/light/(some)air , the 3 best spots to change/improve the coumpound stabilitiet is reanforce at the most stable parts...those are the Nitrogens..in the moleculair ergot structur you see 3"N"'s , these are the nitrogens, one is at the bottom (position 1) , nr 2 is in the mid right position called position nr 6 and the third one is near the top connected to position 8 ( the positions are the number you get when you start counting the connections on the outside of the molecule anti-clockwise , try it !.
people have tried to add more atoms /elements to the "N's possitions and one such experiment was hoffman 25th try for a new compound eventually known as lsd....but here are some lesser know other samples :

1)on the 8 position :

- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1-4 mg. it still unknown if these can cause gangreen / nercosis in certain people.
source (J.ott in Pharmacotheon )

-(S)Lasba : a stereoselective butyl analoog on the 8-amide has been found active in humans a few years ago, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience)
nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url]

-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)

on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.

promising :
- future research is being done to replace the carboxylic acid to a "thoiacid"
this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide.
Warnig : activity and safeties of these compounds are still unknown.

- non-psychoactive ergolines :
bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more,
these are now used as proper migrane- an other-medicine.

- and then there is the sub-family called the clavines who mostly have only 2 nitrogens in their structures which seems to have less medicinal properties and is sleightly less stabiel, therefor the main rearch woldwide is focused on the ergot-family.

Other ergolines

2014-03-11T12:51:31Z

Wallyslow: /* Other ergolines */

== Other ergolines ==

the ergot molecuul is pretty fragile and decomposes easy in some Water/light/(some)air , the 3 best spots to change/improve the coumpound is at the most stable parts...those are the Nitrogens..in the moleculair ergot structur you see 3"N"'s , these are the nitrogens, one is at the bottom (position 1) , nr 2 is in the mid right position called position nr 6 and the third one is near the top connected to position 8 ( the positions are the number you get when you start counting the connections on the outside of the molecule anti-clockwise , try it !.
people have actually tried to add to the "N's possitions through extenting these nitrogen with carbons and such SD was hoffman 25th try for a new compound....but here are some lesser know other samples :

1)on the 8 position :

- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1-4 mg. it still unknown if these can cause gangreen / nercosis in certain people.
source (J.ott in Pharmacotheon )

-(S)Lasba : a stereoselective butyl analoog on the 8-amide has been found active in humans a few years ago, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience)
nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url]

-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)

on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.

promising :
- future research is being done to replace the carboxylic acid to a "thoiacid"
this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide.
Warnig : activity and safeties of these compounds are still unknown.

- non-psychoactive ergolines :
bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more,
these are now used as proper migrane- an other-medicine.

- and then there is the sub-family called the clavines who mostly have only 2 nitrogens in their structures which seems to have less medicinal properties and is sleightly less stabiel, therefor the main rearch woldwide is focused on the ergot-family.

Other ergolines

2014-03-11T12:44:27Z

Wallyslow:

== Other ergolines ==

the ergot molecuul is pretty fragile and decomposes easy in some Water/light/(some)air , the 3 best spots to change/improve the coumpound is at the most stable parts...those are the Nitrogens..in the moleculair ergot structur you see 3"N"'s , these are the nitrogens, one is at the bottom (position 1) , nr 2 is in the mid right position called position nr 6 and the third one is near the top connected to position 8 ( the positions are the number yuo get wen you srt counting the connection on the outside of the molecule anti clockwise , try it !.
people have actually tried to change the "N's possitions through extenting these nitrogen the ergoline compounds lsd follow the same principle,
but here are some lesser know other samples :

1)on the 8 position :

- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1-4 mg. it still unknown if these can cause gangreen / nercosis in certain people.
source (J.ott in Pharmacotheon )

-(S)Lasba : a stereoselective butyl analoog on the 8-amide has been found active in humans a few years ago, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience)
nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url]

-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)

on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.

promising :
- future research is being done to replace the carboxylic acid to a "thoiacid"
this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide.
Warnig : activity and safeties of these compounds are still unknown.

- non-psychoactive ergolines :
bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more,
these are now used as proper migrane- an other-medicine.

- and then there is the sub-family called the clavines who mostly have only 2 nitrogens in their structures which seems to have less medicinal properties and is sleightly less stabiel, therefor the main rearch woldwide is focused on the ergot-family.

Other ergolines

2014-03-11T11:59:16Z

Wallyslow: /* Other ergolines */

== Other ergolines ==

1)on the 8 position :

- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg. it still unknown if these can cause gangreen / nercosis in certain people.
source (J.ott in Pharmacotheon )

-(S)Lasba : a stereoseective butyl analoog on the 8-amide has been found active in humans, but mostly act as a stimulant (source : perdue-uni/nichols/personal exprience)
nice info to be found here : [url}http://bitnest.ca/Silo42/10.1007/BF02245940.pdf[url]

-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)

on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.

promising :
- future research is being done to replace the carboxylic acid to a "thoiacid"
this means at the top the oxygen will be repaced with a sulphur(=thio) and then there is still room for the N-diethyl amide.
Warnig : activity and safeties of these compounds are still unknown.

- non-psychoactive ergolines :
bromocryptine,dihydroergotamine, dihydrolysergic,carbagoline and a few more,
these are now used as proper migrane- an other-medicine.

- and then there is the sub-family called the clavines, which sems to have less medicinal properties therefor the main rearch woldwide is focused on the ergot-family.

Other ergolines

2014-03-11T11:33:21Z

Wallyslow: /* Other ergolines */

Other ergolines

2014-03-11T10:42:07Z

Wallyslow: /* Other ergolines */

== Other ergolines ==

on the 8 position :

- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg.
source (J.ott in Pharmacotheon )
(it still unknown if these can cause gangreen / nercosis in certain people..)

-(s)Lasba : a(stereoseective butyl analoog on the 8-amide) has been found active in humans, but mostly act as a stimulant (perdue uni/nichols/personal exprience)
nice info to be found here : [http://bitnest.ca/Silo42/10.1007/BF02245940.pdf]

-also the morpholine and methyl-ethyl-amide moity are active (hoffman/stoll at sandoz, and shulgin mentions it in Tihkal.)

promising :
- future research is being done to replace the carboxylic acid to a "thoiacid" (actually a thioeaster)
this means at the top the oxygen will be repaced with a sulphur(=thio) and then still have room for the N-diethyl amide. (activity of these compound are still unknown.)

- non-psychoactive ergolines :
bromocryptine, dihydroergotamine , dihydrolysergic, carbagoline and a bunch more , now used as proper migrane- an other-medicine.

on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.

Other ergolines

2014-03-11T10:39:00Z

Wallyslow: -other ergolines-

== Other ergolines ==

on the 8 position :

- some of the lysergic precursors : methysergide, ergometrine and metyl-ergmetrine are slightly active above 1 mg.
source (J.ott in Pharmacotheon )
(it still unknown if these can cause gangreen / nercosis in certain people..)

-(s)Lasba : a(stereoseective butyl analoog op de 8-amide) has been found active in humans, but mostly act as a stimulant (perdue uni/nichols/personal exprience)
nice info to be found here : [http://bitnest.ca/Silo42/10.1007/BF02245940.pdf]

-also the morpholine and methyl-ethyl-amide moity are active (o.a hoffman/stoll and shulgin mentions it in Tihkal.)

promising :
- future research is being done to replace the carboxylic acid to a "thoiacid" (actually a thioeaster)
this means atthe top the top the oxygen might be repaced with a sulphur(=thio) and the still have the N-dimethyl...activity of these compound are still unknown.

- non-psychoactive ergolines :
bromocryptine, dihydroergotamine , dihydrolysergic, carbagoline and a bunch more , now used as proper migrane- an other-medicine.

on the 6 position : AL-LAD, BU-LAD, CYP-LAD, ETH-LAD, PRO-LAD and a few others, Mostly developed by Nichols but in coalition with Shulgin.