DMT-Nexus Wiki - User contributions [en]

Psychedelic Compounds Chemical and Physical Properties

2010-11-05T00:05:56Z

Ouro: /* Freebase Ibogaine */

== Psychedelic Compounds Chemical and Physical Properties ==

=== DMT ===
N,N-Dimethyltryptamine

==== Freebase DMT ====
<table><tr><td>[[Image:dmtfreebase.png]]</td><td></table>
* Appearance: White/Transparent crystals
* CAS Registry Number: 61-50-7
* Composition: C12H16N2
* Molecular Weight: 188.26884 g/mol
* Melting point: 44-68°C (Conflicting reports in literature, as mentioned in [http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* Boiling point:
* XLogP: 2.0
* XLogP3: 2.5 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6089&loc=ec_rcs PubChem])
* pKa: 8.68 ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Stability/Degradation: Oxidation to DMT N-Oxide (yellow oil) in extended presence of oxygen (specialy in evaporation of dmt-containing solvents with heat and/or fan or generally in prolonged exposure to open air). N-oxide may be reverted back to the parent compound by reduction, as described [http://www.anoniem.org/?http://wiki.dmt-nexus.com/DMT_N-Oxide_to_Freebase_DMT in the N-Oxide to Freebase Wiki].
* Solubility:
Very Soluble in Xylene, Toluene, Limonene, acetone, IPA, methanol, ethanol, DCM, chloroform, ether, MEK, butanol

Soluble in naphtha, hexane, heptane but almost insoluble in these solvents at freezing temperatures

Almost insoluble in water.

==== DMT N-Oxide ====
<table><tr><td>[[Image:dmtnoxide.jpg]]</td><td></table>
* Appearance: Yellow oil
* XLogP3: 2
* Solubility:
Soluble in Xylene, Toluene, Limonene
Slightly soluble in basic water
Insoluble in naphtha

==== DMT Fumarate ====

* Molecular Weight: 492.608 g/mol
* Solubility:
Very soluble in water

Soluble in methanol (~10mg/ml)

Soluble in boiling IPA, Practically insoluble in room temp IPA (~1mg/ml), Insoluble in freeze-cold IPA.

Slightly soluble in ethanol (~5mg/ml)

Insoluble in cold acetone

Insoluble in FASI (Fumaric Acid Saturated IPA)

Insoluble in FASA (Fumaric Acid Saturated Acetone)

=== 5-MeO-DMT ===
5-methoxy-N,N-dimethyl-tryptamine

==== Freebase 5-MeO-DMT ====
<table><tr><td>[[Image:5meodmtfreebase.png]]</td><td></table>
* Appearance: Off-white crystals (Sigma Aldrich)
* Composition: C13H18N20
* Molecular Weight: 218.298 g/mol
* Melting Point: 69-70°C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* XLogP: 1.9
* XLogP3: 1.5 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1832&loc=ec_rcs PubChem])
* Stability: Stable under normal temperatures and pressures. Incompatible with strong oxidizing agents, strong acids ([http://ch3v1.chemexper.com/cheminfo/servlet/org.dbcreator.MainServlet?sort=&query=msds._msdsID%3D11173&target=msds&action=PowerSearch&from=0&format=ccd&searchValue=j%60qQ%40%40IVAdbfRfTJTYrRj%40Bfjb%40%40%40&history=off&realQuery=structure._structureID%3D4638142&onclick=1&selectionInfo=&searchTemplate=uniqueMol.structureString%3D%3F+elsor+uniqueMol.structureID%3D%3F&options=brandqtyoffer Source])
* Solubility:
Soluble in: (at least) 20mg/ml 96% ethanol ([https://www.dmt-nexus.com/forum/default.aspx?g=posts&m=176401#post176401 Source])
Practically Insoluble in water ([http://ch3v1.chemexper.com/cheminfo/servlet/org.dbcreator.MainServlet?sort=&query=msds._msdsID%3D11173&target=msds&action=PowerSearch&from=0&format=ccd&searchValue=j%60qQ%40%40IVAdbfRfTJTYrRj%40Bfjb%40%40%40&history=off&realQuery=structure._structureID%3D4638142&onclick=1&selectionInfo=&searchTemplate=uniqueMol.structureString%3D%3F+elsor+uniqueMol.structureID%3D%3F&options=brandqtyoffer Source])

==== 5-MeO-DMT Hydrochloride====
* Melting Point: 145-146°C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])

=== Bufotenine ===
5-HO-DMT - 5-hydroxy-N,N-dimethyl-tryptamine

==== Freebase Bufotenine ====
<table><tr><td>[[Image:bufoteninefreebase.png]]</td><td></table>
* CAS Registry Number: 487-93-4
* Composition: C12H16N2O
* Molecular Weight: 204.268 g/mol
* Melting point:146–147 °C (295–297 °F)
* Boiling point: 320 °C (608 °F)
* XLogP: 1.6
* XLogP3: 1.2 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* pKa:
* Solubility:
Acetone @ 20 C: soluble (5 g/100 ml)

Chloroform @ 20 C: soluble

Dichloromethane @ 20 C: soluble

Dimethyl sulfoxide (DMSO) @ 20 C: soluble (6 g/100 ml)

D-Limonene (Orange Oil) @ 20 C: insoluble

D-Limonene (Orange Oil) @ 176 C: soluble (more than 1.7 g/100 ml)

Dilute Acids and Alkalis: Soluble ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

Ethanol @ 20 C: soluble

Ether @ 20 C: soluble

Ethyl acetate @ 20 C: soluble

Heptane @ 20 C: insoluble

Heptane with 40% MEK @ 20 C: soluble (0.53 g/100 ml)

Heptane with 50% MEK @ 20 C: soluble (1.22 g/100 ml)

IPA @ 20 C: soluble

MEK @ 20 C: soluble

Methanol @ 20 C: soluble

Naphtha @ 20 C: insoluble

Water @ 20 C: nearly insoluble in pure water (no acid or alkali added)

Xylene @ 20 C: nearly insoluble (less than 0.03 g/100 ml)

Xylene @ 144 C: soluble (1.5 g/100 ml)

==== Bufotenine Fumarate ====
* Solubility:
Soluble in water

Insoluble in FASA (Fumaric Acid Saturated Acetone)

=== Psilocin ===
4-HO-DMT - 4-Hydroxy-N,N-dimethyl-tryptamine

==== Freebase Psilocin ====
<table><tr><td>[[Image:psilocinfreebase.png]]</td><td></table>
* CAS Registry Number: 520-53-6
* Composition: C12H16N2O
* Molecular Weight: 204.27 g/mol
* Melting Point: 103-104°C ([http://isomerdesign.com/PiHKAL/read.php?domain=tk&id=18 TIHKAL]) , 173-176°C (Merck Index)
* XLogP3: 2.1 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* Stability/Degradation: Unstable in solution, especially alkaline solution (Merck Index).
* Solubility:
Very slightly sol in water ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

=== Psilocybin ===
4-PO-DMT - O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine

==== Psilocybin (Psilocin Phosphate Ester) ====
<table><tr><td>[[Image:psilocybin.png]]</td><td></table>
* CAS Registry Number: 520-52-5
* Composition: C12H17N2O4P
* Molecular Weight: 284.248141 g/mol
* Melting Point: 220-228° from boiling water; 185-195° from boiling methanol ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* XLogP3: -1.6 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10624&loc=ec_rcs PubChem])
* Stability/Degradation: Dephosphorylated into Psilocin under acidic conditions. Also when ingested, by phosphatases enzymes.
* Solubility:
Soluble in water. Soluble in 20 parts boiling water (= 0.79g/ml in boiling water), 120 parts boiling methanol (= 0.0932g/ml in boiling methanol); difficultly soluble in ethanol. Practically insoluble in chloroform, benzene ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

=== Mescaline ===
3,4,5-trimethoxyphenethylamine

==== Freebase Mescaline ====
<table><tr><td>[[Image:mescalinefreebase.png]]</td><td></table>
* CAS Registry Number: 54-04-6
* Composition: C11H17NO3
* Melting point: 35-36°C (Kindler and Peschke, 103. [http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Boiling point: 180°C (12 mmHg)
* XLogP: 0.6 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* XLogP3: 0.7 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4076&loc=ec_rcs PubChem])
* pKa: 9.56
* Appearance: long needle shaped white crystals
* Molecular weight: 211.26
Notes: forms mescaline carbonate on prolonged exposure to air
* Average dose: 300 to 600 milligrams with a duration of 5 to 12 hours.
* Solubility
Soluble in: alcohol, chloroform, benzene, xylene, toluene, acetone, dichloromethane, highly soluble in isopropyl alcohol, soluble in d-limonene

Moderately soluble in: water

Insoluble in: practically insoluble in ether or petroleum ether
* LD50: i.p. rats 370 mg/kg

==== Mescaline Citrate ====
* Solubility
Soluble in water

Insoluble in: xylene, acetone <nowiki>*</nowiki>

<nowiki>*</nowiki> Possible unreliable web source.

==== Mescaline Hydrochloride ====
<table><tr><td>[[Image:mescalinehcl.png]]</td><td></table>
* Molecular weight: 247.72 (Sigma Aldrich)
* Empirical Formula (Hill Notation): C11H17NO3 • HCl (Sigma Aldrich)
* CAS Number: 832-92-8
* Appearance: colorless crystals, needles
* Melting point: 184°C ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Solubility:
Moderately soluble in: water, alcohol ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index]), methanol (at least 1.0 mg/ml, source Sigma Aldrich solution)
(Merck Index)
Insoluble in: practically insoluble in toluene and acetone, insoluble in isopropyl alcohol, diethyl ether, and d-limonene
* LD50: i.p. rats 132 mg/kg
* Storage temperature: 2-8°C (Sigma Aldrich)
* Isolation: when mescaline hydrochloride is extracted from San Pedro, Achuma, or Peruvian torch, it can be isolated from the other alkaloids by washing it in IPA or acetone (use 10 ml per gram of alkaloids, and wash 2-3 times). The non-mescaline alkaloids dissolve in the IPA or acetate, while the mescaline hydrochloride does not. Note that for the cleanest results use about 2 washes of acetone, and then 2 washes with IPA.

==== Mescaline Picrate ====
* Melting point: mp 222°C.

==== Mescaline Sulfate Dihydrate====
<table><tr><td>[[Image:mescalinesulfate.png]]</td><td></table>
* Composition: (C11H17NO3)2 • H2SO4 • 2H2O
* Appearance: prisms
* Melting point: 183–186 °C (361–367 °F)
* Molecular Weight: 309.33606
* Soluble in: hot water, methanol
* Almost insoluble in: near freezing water, alcohol, acetone <nowiki>*</nowiki>
<nowiki>*</nowiki> Possible unreliable web source.

==== Mescaline Fumarate ====
* Composition: unknown (it may be a one to one salt or may not be)
* Appearance: unknown
* Melting point: unknown
* Solubility
Soluble in: water<nowiki>**</nowiki>, acetone<nowiki>**</nowiki>

Insoluble in: unknown
<nowiki>**</nowiki> This information is from various SWIMs on this forum.

==== Mescaline Acetate ====
* Composition: unknown
* Appearance: white free flowing powder with a slight waxy texture <nowiki>***</nowiki>
* Melting point: unknown
* Solubility:
Soluble in: water<nowiki>***</nowiki>, isopropyl alcohol<nowiki>***</nowiki>, acetone<nowiki>***</nowiki>, DMSO<nowiki>***</nowiki> (more than 5 grams/100 ml), boiling MEK***

Insoluble in: xylene, d-limonene, cold MEK (Methyl Ethyl Ketone) <nowiki>***</nowiki>

<nowiki>***</nowiki> This information was validated by SWIM and is reliable.
* Isolation: when mescaline acetate is extracted from San Pedro, Achuma, or Peruvian torch, it can be isolated from the other alkaloids by washing it in cold MEK (use 10 ml per gram of alkaloids, and wash 2-3 times). The non-mescaline alkaloids dissolve in the MEK, while the mescaline acetate does not. Mescaline acetate can be recrystallized in MEK by boiling the MEK and then freezing it overnight.

=== Ibogaine ===
12-methoxyibogamine

==== Freebase Ibogaine ====
<table><tr><td>[[Image:ibogainefreebase.png]]</td><td></table>
* CAS Registry Number: 83-74-9
* Composition: C20H26N2O
* Molecular Weight: 310.43324 g/mol
* Melting Point: 152-153 °C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* XLogP3: 3.9 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* pKa: 8.1 in 80% methylcellosolve ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Solubility: Soluble in limonene ([http://www.anoniem.org/?https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=10651 Non-Toxic Iboga Extraction]) soluble in acetone (merck)

==== Ibogaine Hydrochloride ====
* Melting Point: 299-300 °C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* Solubility: Soluble in water, methanol (Sigma Aldrich), slightly soluble in acetone (merck)

=== Voacangine ===
12-methoxyibogamine-18-carboxylic acid methyl ester

==== Voacangine ====
<table><tr><td>[[Image:voacangine.png]]</td><td></table>
* Composition: C22H28N2O3
* Molecular Weight: 368.46932 g/mole
* Melting Point: 136–137 °C ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* pKa: 7.4 (40% aq methanol); 5.73 (33% DMF) ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* XLogP3-AA: 3.5 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])

=== LSA (ergine) ===
Lysergamide

==== Freebase LSA ====
<table><tr><td>[[Image:lsafreebase.png]]</td><td></table>
CAS Registry Number: 478-94-4
* Composition: C16H17N3O
* Molecular Weight: 267.32568 g/mol
* XLogP3: 1.6 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=442072&loc=ec_rcs PubChem])

=== Muscimol ===
Pantherine, Agarine

==== Freebase Muscimol ====
<table><tr><td>[[Image:muscimolfreebase.png]]</td><td></table>
* Appearance: White powder (Sigma Aldrich)
* CAS Registry Number: 2763-96-4
* Composition: C4H6N2O2
* Molecular Weight: 114.10264 g/mol
* Melting Point: 175°C (Merck Index)
* XLogP3-AA: -1.4 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4266&loc=ec_rcs PubChem])

=== Salvinorin A ===
Note: Technically NOT an alkaloid, as it contains no nitrogen. It is a trans-neoclerodane diterpene.

==== Salvinorin A ====
<table><tr><td>[[Image:salvinorina.png]]</td><td></table>
* Composition: C23H28O8
* Molecular Weight: 432.46362 g/mol
* Melting Point:242-244 – 238-240 °C (Wikipedia)
* Boiling Pont: 760.2 °C (1400 °F) (Wikipedia)
* XLogP3-AA: 2.5 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])

=== Elemicin ===
1,2,3-trimethoxy-5-allylbenzene

Note: Technically NOT an alkaloid, as it contains no nitrogen.

==== Elemicin ====
<table><tr><td>[[Image:elemicin.png]]</td><td></table>

* CAS Number: 487-11-6
* Molecular Formula: C12H16O3
* Molecular Weight: 208.25364 g/mol
* Boiling Point: 152-156 °C @ 17 mmHg, 144-147 °C @ 10 mmHg ([http://www.thegoodscentscompany.com/data/rw1021681.html Source]), 146-147 °C ([http://www.chemyq.com/En/xz/xz3/20815lmxvj.htm Source 1] [http://www.chunyuan.com.cn/zhanshishow.asp?id=94 Source 2]), 279.8 °C @ 760 mmHg ([http://www.chemspider.com/Chemical-Structure.9830.html ChemSpider])
* XlogP3: 2.5 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* Solubility:
Soluble in alcohol, Insoluble in water ([http://www.thegoodscentscompany.com/data/rw1021681.html Source])

=== Harmine ===
7-methoxy-β-carboline

==== Freebase Harmine ====
<table><tr><td>[[Image:harminefreebase.png]]</td><td></table>
* Composition: C13H12N2O
* Molecular Weight: 212.25 (Sigma Aldrich)
* Melting point: 262-264 °C (Sigma Aldrich)
* Boiling point:
* XLogP: 2.5
* XLogP3: 3.6
* pKa: 7.7
* Solubility:
Insoluble in basic water, poorly soluble in distilled water
* Isolation: To separate from harmaline, using pKa properties, raise pH of solution containing both alkaloids to pH 8.75 to precipitate 92% of harmine and only 8% Harmaline. Filter to retrieve precipitated alkaloids, and raise the pH further to retrieve the bulk of harmaline. Check the [https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=5725 freebase percentage calculator thread] and the [http://wiki.dmt-nexus.com/Harmalas_Extraction_and_Separation_Guide Harmala Extraction Guide] for more info.

==== Harmine Hydrochloride ====
<table><tr><td>[[Image:harminehcl.png]]</td><td></table>
* Melting Point: 321 °C
* Solubility:
Soluble in water

Insoluble in salt-saturated water

=== Harmaline ===
3,4-dihydro-7-methoxy-1-methyl-β-carboline

==== Freebase Harmaline ====
<table><tr><td>[[Image:harmaline.png]]</td><td></table>
* Composition: C13H14N2O
* Melting point: 232-234 °C (Sigma Aldrich)
* Boiling point: 120-140 °C at 0.001 mm/Hg ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* XLogP: 0.8
* XLogP3: 1.2
* pKa: 9.8
* Solubility:
Slightly soluble in basic water, poorly soluble in distilled water
* Isolation: To separate from harmine, using pKa properties, raise pH of solution containing both alkaloids to pH 8.75 to precipitate 92% of harmine and only 8% Harmaline. Filter to retrieve precipitated alkaloids, and raise the pH further to retrieve the bulk of harmaline. Check the [https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=5725 freebase percentage calculator thread] and the [http://wiki.dmt-nexus.com/Harmalas_Extraction_and_Separation_Guide Harmala Extraction Guide] for more info.

==== Harmaline Hydrochloride ====
* Solubility:
Soluble in water

Insoluble in salt-saturated water

=== THH ===
Tetrahydroharmine - 7-methoxy-1-methyl-1,2,3,4-tetrahydro-β-carboline

==== Freebase THH ====
<table><tr><td>[[Image:thhfreebase.png]]</td><td></table>
* Composition: C13H16N2O
* Molecular Weight: 216.27894 g/mol
* Melting Point: 187-190 °C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* XlogP: 1.9
* XLogP3: 1.9

Solubility: poorly soluble in distilled water

==== THH Hydrochloride ====
<table><tr><td>[[Image:thhhcl.png]]</td><td></table>
* Composition: C13H17ClN2O
* Molecular Weight: 252.73988 g/mol
* Melting Point: 232–234 °C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])

== Relevant NOT psychedelic compounds ==

=== Gramine ===
N,N-Dimethyl-1H-indole-3-methanamine

==== Freebase Gramine ====
<table><tr><td>[[Image:graminefreebase.png]]</td><td></table>
* Composition: C11H14N2
* Molecular Weight: 174.24226 g/mol
* Melting point: 138-139°C (Merck)
* Boiling point:
* XLogP3: 1.8
* pKa:
* Solubility:
Sol in alcohol, ether, chloroform; slightly sol in cold acetone. Practically insol in petr ether, water. (Merck Index)

=== Hordenine ===
N,N-dimethyltyramine

==== Freebase Hordenine ====
<table><tr><td>[[Image:hordeninefreebase.png]]</td><td></table>
* CAS Registry Number: 539-15-1
* Composition: C10H15NO
* Molecular Weight: 165.23 g/mol
* Melting point: 117-118° ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Boiling point: 173° @ 11mmHg ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* XlogP3: 2.1 (PubChem)
* Solubility:
Very sol in alcohol, chloroform, ether. 7 grams dissolve in 1000 ml water. Sparingly sol in benzene, toluene, xylene. Practically insol in petr ether. ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

==== Hordenine Hydrochloride ====
<table><tr><td>[[Image:hordeninehcl.png]]</td><td></table>
* CAS Registry Number: 6027-23-2
* Composition: C10H15NO.HCl
* Molecular Weight: 201.70 g/mol
* Melting point: 177° ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Solubility:
Very sol in water. ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

== Solvents and Alkaloids XlogP and XlogP3 ==

'''Alkaloid XlogP list'''

* 0.1 - 6-methoxy-2-methyl-beta-Carboline
* 0.7 - Beta-carboline, 6-methoxy-1,2-dimethyl-1,2-Dimethyl-2H-beta-carbolin-6-yl methyl ether
* 0.7 - Mescaline
* 0.8 - Harmaline
* 1.0 - 5-HO-Tryptamine (serotonin)
* 1.3 - 5-HO-DMT N-oxide (Bufotenine N-oxide)
* 1.6 - 5-HO-DMT (bufotenine)
* 1.7 - N-Methylserotonin
* 1.7 - DMT N-oxide (Dimethyltryptamine N-oxide)
* 1.7 - 5-MeO-NMT (5-Methoxy-N-methyltryptamine)
* 1.7 - 2-Methyl-1,2,3,4-tetrahydro-beta-carboline
* 1.8 - NMT (N-Methyltryptamine)
* 1.9 - 5-MeO-DMT (methoxybufotenin)
* 1.9 - Tetra−Hydro−Harmine (THH)
* 2.0 - DMT (Dimethyltryptamine)
* 2.5 - Harmine

'''Alkaloid XlogP3 list'''

* -1.4 - Muscimol
* -1.6 - Psilocybin
* 0.6 - Harmalol
* 0.7 - Mescaline
* 1.2 - Harmaline
* 1.2 - Bufotenine
* 1.5 - 5-MeO-DMT
* 1.6 - LSA (ergine)
* 1.8 - Gramine
* 1.9 - Tetrahydroharmine
* 2.0 - DMT N-oxide
* 2.1 - Psilocin
* 2.5 - DMT
* 2.5 - Salvinorin A
* 2.5 - Elemicin
* 3.5 - Voacangine
* 3.6 - Harmine
* 3.6 - Harman
* 3.9 - Ibogaine

Lower XlogP values are more water soluble, and higher XlogP values are more non-polar soluble.

'''Solvent XlogP list'''

* -0.7 - DMSO
* -0.5 - Methanol
* -0.1 - Ethyl Alcohol
* 0.2 - Acetone
* 0.4 - IPA
* 0.4 - MEK (Methyl Ethyl Ketone)
* 0.7 - Ethyl Acetate
* 0.9 - Ethyl Ether
* 1.5 - DCM
* 2.1 - Chloroform
* 2.5 - Toluene
* 2.5 - Xylene
* 3.7 - Limonene
* 4.3 - Heptane (similar to naphtha)

Psychedelic Compounds Chemical and Physical Properties

2010-11-05T00:05:24Z

Ouro: /* Ibogaine Hydrochloride */

== Psychedelic Compounds Chemical and Physical Properties ==

=== DMT ===
N,N-Dimethyltryptamine

==== Freebase DMT ====
<table><tr><td>[[Image:dmtfreebase.png]]</td><td></table>
* Appearance: White/Transparent crystals
* CAS Registry Number: 61-50-7
* Composition: C12H16N2
* Molecular Weight: 188.26884 g/mol
* Melting point: 44-68°C (Conflicting reports in literature, as mentioned in [http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* Boiling point:
* XLogP: 2.0
* XLogP3: 2.5 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6089&loc=ec_rcs PubChem])
* pKa: 8.68 ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Stability/Degradation: Oxidation to DMT N-Oxide (yellow oil) in extended presence of oxygen (specialy in evaporation of dmt-containing solvents with heat and/or fan or generally in prolonged exposure to open air). N-oxide may be reverted back to the parent compound by reduction, as described [http://www.anoniem.org/?http://wiki.dmt-nexus.com/DMT_N-Oxide_to_Freebase_DMT in the N-Oxide to Freebase Wiki].
* Solubility:
Very Soluble in Xylene, Toluene, Limonene, acetone, IPA, methanol, ethanol, DCM, chloroform, ether, MEK, butanol

Soluble in naphtha, hexane, heptane but almost insoluble in these solvents at freezing temperatures

Almost insoluble in water.

==== DMT N-Oxide ====
<table><tr><td>[[Image:dmtnoxide.jpg]]</td><td></table>
* Appearance: Yellow oil
* XLogP3: 2
* Solubility:
Soluble in Xylene, Toluene, Limonene
Slightly soluble in basic water
Insoluble in naphtha

==== DMT Fumarate ====

* Molecular Weight: 492.608 g/mol
* Solubility:
Very soluble in water

Soluble in methanol (~10mg/ml)

Soluble in boiling IPA, Practically insoluble in room temp IPA (~1mg/ml), Insoluble in freeze-cold IPA.

Slightly soluble in ethanol (~5mg/ml)

Insoluble in cold acetone

Insoluble in FASI (Fumaric Acid Saturated IPA)

Insoluble in FASA (Fumaric Acid Saturated Acetone)

=== 5-MeO-DMT ===
5-methoxy-N,N-dimethyl-tryptamine

==== Freebase 5-MeO-DMT ====
<table><tr><td>[[Image:5meodmtfreebase.png]]</td><td></table>
* Appearance: Off-white crystals (Sigma Aldrich)
* Composition: C13H18N20
* Molecular Weight: 218.298 g/mol
* Melting Point: 69-70°C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* XLogP: 1.9
* XLogP3: 1.5 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1832&loc=ec_rcs PubChem])
* Stability: Stable under normal temperatures and pressures. Incompatible with strong oxidizing agents, strong acids ([http://ch3v1.chemexper.com/cheminfo/servlet/org.dbcreator.MainServlet?sort=&query=msds._msdsID%3D11173&target=msds&action=PowerSearch&from=0&format=ccd&searchValue=j%60qQ%40%40IVAdbfRfTJTYrRj%40Bfjb%40%40%40&history=off&realQuery=structure._structureID%3D4638142&onclick=1&selectionInfo=&searchTemplate=uniqueMol.structureString%3D%3F+elsor+uniqueMol.structureID%3D%3F&options=brandqtyoffer Source])
* Solubility:
Soluble in: (at least) 20mg/ml 96% ethanol ([https://www.dmt-nexus.com/forum/default.aspx?g=posts&m=176401#post176401 Source])
Practically Insoluble in water ([http://ch3v1.chemexper.com/cheminfo/servlet/org.dbcreator.MainServlet?sort=&query=msds._msdsID%3D11173&target=msds&action=PowerSearch&from=0&format=ccd&searchValue=j%60qQ%40%40IVAdbfRfTJTYrRj%40Bfjb%40%40%40&history=off&realQuery=structure._structureID%3D4638142&onclick=1&selectionInfo=&searchTemplate=uniqueMol.structureString%3D%3F+elsor+uniqueMol.structureID%3D%3F&options=brandqtyoffer Source])

==== 5-MeO-DMT Hydrochloride====
* Melting Point: 145-146°C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])

=== Bufotenine ===
5-HO-DMT - 5-hydroxy-N,N-dimethyl-tryptamine

==== Freebase Bufotenine ====
<table><tr><td>[[Image:bufoteninefreebase.png]]</td><td></table>
* CAS Registry Number: 487-93-4
* Composition: C12H16N2O
* Molecular Weight: 204.268 g/mol
* Melting point:146–147 °C (295–297 °F)
* Boiling point: 320 °C (608 °F)
* XLogP: 1.6
* XLogP3: 1.2 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* pKa:
* Solubility:
Acetone @ 20 C: soluble (5 g/100 ml)

Chloroform @ 20 C: soluble

Dichloromethane @ 20 C: soluble

Dimethyl sulfoxide (DMSO) @ 20 C: soluble (6 g/100 ml)

D-Limonene (Orange Oil) @ 20 C: insoluble

D-Limonene (Orange Oil) @ 176 C: soluble (more than 1.7 g/100 ml)

Dilute Acids and Alkalis: Soluble ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

Ethanol @ 20 C: soluble

Ether @ 20 C: soluble

Ethyl acetate @ 20 C: soluble

Heptane @ 20 C: insoluble

Heptane with 40% MEK @ 20 C: soluble (0.53 g/100 ml)

Heptane with 50% MEK @ 20 C: soluble (1.22 g/100 ml)

IPA @ 20 C: soluble

MEK @ 20 C: soluble

Methanol @ 20 C: soluble

Naphtha @ 20 C: insoluble

Water @ 20 C: nearly insoluble in pure water (no acid or alkali added)

Xylene @ 20 C: nearly insoluble (less than 0.03 g/100 ml)

Xylene @ 144 C: soluble (1.5 g/100 ml)

==== Bufotenine Fumarate ====
* Solubility:
Soluble in water

Insoluble in FASA (Fumaric Acid Saturated Acetone)

=== Psilocin ===
4-HO-DMT - 4-Hydroxy-N,N-dimethyl-tryptamine

==== Freebase Psilocin ====
<table><tr><td>[[Image:psilocinfreebase.png]]</td><td></table>
* CAS Registry Number: 520-53-6
* Composition: C12H16N2O
* Molecular Weight: 204.27 g/mol
* Melting Point: 103-104°C ([http://isomerdesign.com/PiHKAL/read.php?domain=tk&id=18 TIHKAL]) , 173-176°C (Merck Index)
* XLogP3: 2.1 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* Stability/Degradation: Unstable in solution, especially alkaline solution (Merck Index).
* Solubility:
Very slightly sol in water ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

=== Psilocybin ===
4-PO-DMT - O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine

==== Psilocybin (Psilocin Phosphate Ester) ====
<table><tr><td>[[Image:psilocybin.png]]</td><td></table>
* CAS Registry Number: 520-52-5
* Composition: C12H17N2O4P
* Molecular Weight: 284.248141 g/mol
* Melting Point: 220-228° from boiling water; 185-195° from boiling methanol ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* XLogP3: -1.6 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10624&loc=ec_rcs PubChem])
* Stability/Degradation: Dephosphorylated into Psilocin under acidic conditions. Also when ingested, by phosphatases enzymes.
* Solubility:
Soluble in water. Soluble in 20 parts boiling water (= 0.79g/ml in boiling water), 120 parts boiling methanol (= 0.0932g/ml in boiling methanol); difficultly soluble in ethanol. Practically insoluble in chloroform, benzene ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

=== Mescaline ===
3,4,5-trimethoxyphenethylamine

==== Freebase Mescaline ====
<table><tr><td>[[Image:mescalinefreebase.png]]</td><td></table>
* CAS Registry Number: 54-04-6
* Composition: C11H17NO3
* Melting point: 35-36°C (Kindler and Peschke, 103. [http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Boiling point: 180°C (12 mmHg)
* XLogP: 0.6 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* XLogP3: 0.7 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4076&loc=ec_rcs PubChem])
* pKa: 9.56
* Appearance: long needle shaped white crystals
* Molecular weight: 211.26
Notes: forms mescaline carbonate on prolonged exposure to air
* Average dose: 300 to 600 milligrams with a duration of 5 to 12 hours.
* Solubility
Soluble in: alcohol, chloroform, benzene, xylene, toluene, acetone, dichloromethane, highly soluble in isopropyl alcohol, soluble in d-limonene

Moderately soluble in: water

Insoluble in: practically insoluble in ether or petroleum ether
* LD50: i.p. rats 370 mg/kg

==== Mescaline Citrate ====
* Solubility
Soluble in water

Insoluble in: xylene, acetone <nowiki>*</nowiki>

<nowiki>*</nowiki> Possible unreliable web source.

==== Mescaline Hydrochloride ====
<table><tr><td>[[Image:mescalinehcl.png]]</td><td></table>
* Molecular weight: 247.72 (Sigma Aldrich)
* Empirical Formula (Hill Notation): C11H17NO3 • HCl (Sigma Aldrich)
* CAS Number: 832-92-8
* Appearance: colorless crystals, needles
* Melting point: 184°C ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Solubility:
Moderately soluble in: water, alcohol ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index]), methanol (at least 1.0 mg/ml, source Sigma Aldrich solution)
(Merck Index)
Insoluble in: practically insoluble in toluene and acetone, insoluble in isopropyl alcohol, diethyl ether, and d-limonene
* LD50: i.p. rats 132 mg/kg
* Storage temperature: 2-8°C (Sigma Aldrich)
* Isolation: when mescaline hydrochloride is extracted from San Pedro, Achuma, or Peruvian torch, it can be isolated from the other alkaloids by washing it in IPA or acetone (use 10 ml per gram of alkaloids, and wash 2-3 times). The non-mescaline alkaloids dissolve in the IPA or acetate, while the mescaline hydrochloride does not. Note that for the cleanest results use about 2 washes of acetone, and then 2 washes with IPA.

==== Mescaline Picrate ====
* Melting point: mp 222°C.

==== Mescaline Sulfate Dihydrate====
<table><tr><td>[[Image:mescalinesulfate.png]]</td><td></table>
* Composition: (C11H17NO3)2 • H2SO4 • 2H2O
* Appearance: prisms
* Melting point: 183–186 °C (361–367 °F)
* Molecular Weight: 309.33606
* Soluble in: hot water, methanol
* Almost insoluble in: near freezing water, alcohol, acetone <nowiki>*</nowiki>
<nowiki>*</nowiki> Possible unreliable web source.

==== Mescaline Fumarate ====
* Composition: unknown (it may be a one to one salt or may not be)
* Appearance: unknown
* Melting point: unknown
* Solubility
Soluble in: water<nowiki>**</nowiki>, acetone<nowiki>**</nowiki>

Insoluble in: unknown
<nowiki>**</nowiki> This information is from various SWIMs on this forum.

==== Mescaline Acetate ====
* Composition: unknown
* Appearance: white free flowing powder with a slight waxy texture <nowiki>***</nowiki>
* Melting point: unknown
* Solubility:
Soluble in: water<nowiki>***</nowiki>, isopropyl alcohol<nowiki>***</nowiki>, acetone<nowiki>***</nowiki>, DMSO<nowiki>***</nowiki> (more than 5 grams/100 ml), boiling MEK***

Insoluble in: xylene, d-limonene, cold MEK (Methyl Ethyl Ketone) <nowiki>***</nowiki>

<nowiki>***</nowiki> This information was validated by SWIM and is reliable.
* Isolation: when mescaline acetate is extracted from San Pedro, Achuma, or Peruvian torch, it can be isolated from the other alkaloids by washing it in cold MEK (use 10 ml per gram of alkaloids, and wash 2-3 times). The non-mescaline alkaloids dissolve in the MEK, while the mescaline acetate does not. Mescaline acetate can be recrystallized in MEK by boiling the MEK and then freezing it overnight.

=== Ibogaine ===
12-methoxyibogamine

==== Freebase Ibogaine ====
<table><tr><td>[[Image:ibogainefreebase.png]]</td><td></table>
* CAS Registry Number: 83-74-9
* Composition: C20H26N2O
* Molecular Weight: 310.43324 g/mol
* Melting Point: 152-153 °C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* XLogP3: 3.9 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* pKa: 8.1 in 80% methylcellosolve ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Solubility: Soluble in limonene ([http://www.anoniem.org/?https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=10651 Non-Toxic Iboga Extraction]) soluble in acetone

==== Ibogaine Hydrochloride ====
* Melting Point: 299-300 °C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* Solubility: Soluble in water, methanol (Sigma Aldrich), slightly soluble in acetone (merck)

=== Voacangine ===
12-methoxyibogamine-18-carboxylic acid methyl ester

==== Voacangine ====
<table><tr><td>[[Image:voacangine.png]]</td><td></table>
* Composition: C22H28N2O3
* Molecular Weight: 368.46932 g/mole
* Melting Point: 136–137 °C ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* pKa: 7.4 (40% aq methanol); 5.73 (33% DMF) ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* XLogP3-AA: 3.5 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])

=== LSA (ergine) ===
Lysergamide

==== Freebase LSA ====
<table><tr><td>[[Image:lsafreebase.png]]</td><td></table>
CAS Registry Number: 478-94-4
* Composition: C16H17N3O
* Molecular Weight: 267.32568 g/mol
* XLogP3: 1.6 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=442072&loc=ec_rcs PubChem])

=== Muscimol ===
Pantherine, Agarine

==== Freebase Muscimol ====
<table><tr><td>[[Image:muscimolfreebase.png]]</td><td></table>
* Appearance: White powder (Sigma Aldrich)
* CAS Registry Number: 2763-96-4
* Composition: C4H6N2O2
* Molecular Weight: 114.10264 g/mol
* Melting Point: 175°C (Merck Index)
* XLogP3-AA: -1.4 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4266&loc=ec_rcs PubChem])

=== Salvinorin A ===
Note: Technically NOT an alkaloid, as it contains no nitrogen. It is a trans-neoclerodane diterpene.

==== Salvinorin A ====
<table><tr><td>[[Image:salvinorina.png]]</td><td></table>
* Composition: C23H28O8
* Molecular Weight: 432.46362 g/mol
* Melting Point:242-244 – 238-240 °C (Wikipedia)
* Boiling Pont: 760.2 °C (1400 °F) (Wikipedia)
* XLogP3-AA: 2.5 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])

=== Elemicin ===
1,2,3-trimethoxy-5-allylbenzene

Note: Technically NOT an alkaloid, as it contains no nitrogen.

==== Elemicin ====
<table><tr><td>[[Image:elemicin.png]]</td><td></table>

* CAS Number: 487-11-6
* Molecular Formula: C12H16O3
* Molecular Weight: 208.25364 g/mol
* Boiling Point: 152-156 °C @ 17 mmHg, 144-147 °C @ 10 mmHg ([http://www.thegoodscentscompany.com/data/rw1021681.html Source]), 146-147 °C ([http://www.chemyq.com/En/xz/xz3/20815lmxvj.htm Source 1] [http://www.chunyuan.com.cn/zhanshishow.asp?id=94 Source 2]), 279.8 °C @ 760 mmHg ([http://www.chemspider.com/Chemical-Structure.9830.html ChemSpider])
* XlogP3: 2.5 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* Solubility:
Soluble in alcohol, Insoluble in water ([http://www.thegoodscentscompany.com/data/rw1021681.html Source])

=== Harmine ===
7-methoxy-β-carboline

==== Freebase Harmine ====
<table><tr><td>[[Image:harminefreebase.png]]</td><td></table>
* Composition: C13H12N2O
* Molecular Weight: 212.25 (Sigma Aldrich)
* Melting point: 262-264 °C (Sigma Aldrich)
* Boiling point:
* XLogP: 2.5
* XLogP3: 3.6
* pKa: 7.7
* Solubility:
Insoluble in basic water, poorly soluble in distilled water
* Isolation: To separate from harmaline, using pKa properties, raise pH of solution containing both alkaloids to pH 8.75 to precipitate 92% of harmine and only 8% Harmaline. Filter to retrieve precipitated alkaloids, and raise the pH further to retrieve the bulk of harmaline. Check the [https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=5725 freebase percentage calculator thread] and the [http://wiki.dmt-nexus.com/Harmalas_Extraction_and_Separation_Guide Harmala Extraction Guide] for more info.

==== Harmine Hydrochloride ====
<table><tr><td>[[Image:harminehcl.png]]</td><td></table>
* Melting Point: 321 °C
* Solubility:
Soluble in water

Insoluble in salt-saturated water

=== Harmaline ===
3,4-dihydro-7-methoxy-1-methyl-β-carboline

==== Freebase Harmaline ====
<table><tr><td>[[Image:harmaline.png]]</td><td></table>
* Composition: C13H14N2O
* Melting point: 232-234 °C (Sigma Aldrich)
* Boiling point: 120-140 °C at 0.001 mm/Hg ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* XLogP: 0.8
* XLogP3: 1.2
* pKa: 9.8
* Solubility:
Slightly soluble in basic water, poorly soluble in distilled water
* Isolation: To separate from harmine, using pKa properties, raise pH of solution containing both alkaloids to pH 8.75 to precipitate 92% of harmine and only 8% Harmaline. Filter to retrieve precipitated alkaloids, and raise the pH further to retrieve the bulk of harmaline. Check the [https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=5725 freebase percentage calculator thread] and the [http://wiki.dmt-nexus.com/Harmalas_Extraction_and_Separation_Guide Harmala Extraction Guide] for more info.

==== Harmaline Hydrochloride ====
* Solubility:
Soluble in water

Insoluble in salt-saturated water

=== THH ===
Tetrahydroharmine - 7-methoxy-1-methyl-1,2,3,4-tetrahydro-β-carboline

==== Freebase THH ====
<table><tr><td>[[Image:thhfreebase.png]]</td><td></table>
* Composition: C13H16N2O
* Molecular Weight: 216.27894 g/mol
* Melting Point: 187-190 °C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* XlogP: 1.9
* XLogP3: 1.9

Solubility: poorly soluble in distilled water

==== THH Hydrochloride ====
<table><tr><td>[[Image:thhhcl.png]]</td><td></table>
* Composition: C13H17ClN2O
* Molecular Weight: 252.73988 g/mol
* Melting Point: 232–234 °C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])

== Relevant NOT psychedelic compounds ==

=== Gramine ===
N,N-Dimethyl-1H-indole-3-methanamine

==== Freebase Gramine ====
<table><tr><td>[[Image:graminefreebase.png]]</td><td></table>
* Composition: C11H14N2
* Molecular Weight: 174.24226 g/mol
* Melting point: 138-139°C (Merck)
* Boiling point:
* XLogP3: 1.8
* pKa:
* Solubility:
Sol in alcohol, ether, chloroform; slightly sol in cold acetone. Practically insol in petr ether, water. (Merck Index)

=== Hordenine ===
N,N-dimethyltyramine

==== Freebase Hordenine ====
<table><tr><td>[[Image:hordeninefreebase.png]]</td><td></table>
* CAS Registry Number: 539-15-1
* Composition: C10H15NO
* Molecular Weight: 165.23 g/mol
* Melting point: 117-118° ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Boiling point: 173° @ 11mmHg ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* XlogP3: 2.1 (PubChem)
* Solubility:
Very sol in alcohol, chloroform, ether. 7 grams dissolve in 1000 ml water. Sparingly sol in benzene, toluene, xylene. Practically insol in petr ether. ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

==== Hordenine Hydrochloride ====
<table><tr><td>[[Image:hordeninehcl.png]]</td><td></table>
* CAS Registry Number: 6027-23-2
* Composition: C10H15NO.HCl
* Molecular Weight: 201.70 g/mol
* Melting point: 177° ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Solubility:
Very sol in water. ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

== Solvents and Alkaloids XlogP and XlogP3 ==

'''Alkaloid XlogP list'''

* 0.1 - 6-methoxy-2-methyl-beta-Carboline
* 0.7 - Beta-carboline, 6-methoxy-1,2-dimethyl-1,2-Dimethyl-2H-beta-carbolin-6-yl methyl ether
* 0.7 - Mescaline
* 0.8 - Harmaline
* 1.0 - 5-HO-Tryptamine (serotonin)
* 1.3 - 5-HO-DMT N-oxide (Bufotenine N-oxide)
* 1.6 - 5-HO-DMT (bufotenine)
* 1.7 - N-Methylserotonin
* 1.7 - DMT N-oxide (Dimethyltryptamine N-oxide)
* 1.7 - 5-MeO-NMT (5-Methoxy-N-methyltryptamine)
* 1.7 - 2-Methyl-1,2,3,4-tetrahydro-beta-carboline
* 1.8 - NMT (N-Methyltryptamine)
* 1.9 - 5-MeO-DMT (methoxybufotenin)
* 1.9 - Tetra−Hydro−Harmine (THH)
* 2.0 - DMT (Dimethyltryptamine)
* 2.5 - Harmine

'''Alkaloid XlogP3 list'''

* -1.4 - Muscimol
* -1.6 - Psilocybin
* 0.6 - Harmalol
* 0.7 - Mescaline
* 1.2 - Harmaline
* 1.2 - Bufotenine
* 1.5 - 5-MeO-DMT
* 1.6 - LSA (ergine)
* 1.8 - Gramine
* 1.9 - Tetrahydroharmine
* 2.0 - DMT N-oxide
* 2.1 - Psilocin
* 2.5 - DMT
* 2.5 - Salvinorin A
* 2.5 - Elemicin
* 3.5 - Voacangine
* 3.6 - Harmine
* 3.6 - Harman
* 3.9 - Ibogaine

Lower XlogP values are more water soluble, and higher XlogP values are more non-polar soluble.

'''Solvent XlogP list'''

* -0.7 - DMSO
* -0.5 - Methanol
* -0.1 - Ethyl Alcohol
* 0.2 - Acetone
* 0.4 - IPA
* 0.4 - MEK (Methyl Ethyl Ketone)
* 0.7 - Ethyl Acetate
* 0.9 - Ethyl Ether
* 1.5 - DCM
* 2.1 - Chloroform
* 2.5 - Toluene
* 2.5 - Xylene
* 3.7 - Limonene
* 4.3 - Heptane (similar to naphtha)

Psychedelic Compounds Chemical and Physical Properties

2010-11-04T21:17:18Z

Ouro: updated ibogaine solubilities in acetone, harmalas solubility in distilled water

== Psychedelic Compounds Chemical and Physical Properties ==

=== DMT ===
N,N-Dimethyltryptamine

==== Freebase DMT ====
<table><tr><td>[[Image:dmtfreebase.png]]</td><td></table>
* Appearance: White/Transparent crystals
* CAS Registry Number: 61-50-7
* Composition: C12H16N2
* Molecular Weight: 188.26884 g/mol
* Melting point: 44-68°C (Conflicting reports in literature, as mentioned in [http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* Boiling point:
* XLogP: 2.0
* XLogP3: 2.5 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6089&loc=ec_rcs PubChem])
* pKa: 8.68 ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Stability/Degradation: Oxidation to DMT N-Oxide (yellow oil) in extended presence of oxygen (specialy in evaporation of dmt-containing solvents with heat and/or fan or generally in prolonged exposure to open air). N-oxide may be reverted back to the parent compound by reduction, as described [http://www.anoniem.org/?http://wiki.dmt-nexus.com/DMT_N-Oxide_to_Freebase_DMT in the N-Oxide to Freebase Wiki].
* Solubility:
Very Soluble in Xylene, Toluene, Limonene, acetone, IPA, methanol, ethanol, DCM, chloroform, ether, MEK, butanol

Soluble in naphtha, hexane, heptane but almost insoluble in these solvents at freezing temperatures

Almost insoluble in water.

==== DMT N-Oxide ====
<table><tr><td>[[Image:dmtnoxide.jpg]]</td><td></table>
* Appearance: Yellow oil
* XLogP3: 2
* Solubility:
Soluble in Xylene, Toluene, Limonene
Slightly soluble in basic water
Insoluble in naphtha

==== DMT Fumarate ====

* Molecular Weight: 492.608 g/mol
* Solubility:
Very soluble in water

Soluble in methanol (~10mg/ml)

Soluble in boiling IPA, Practically insoluble in room temp IPA (~1mg/ml), Insoluble in freeze-cold IPA.

Slightly soluble in ethanol (~5mg/ml)

Insoluble in cold acetone

Insoluble in FASI (Fumaric Acid Saturated IPA)

Insoluble in FASA (Fumaric Acid Saturated Acetone)

=== 5-MeO-DMT ===
5-methoxy-N,N-dimethyl-tryptamine

==== Freebase 5-MeO-DMT ====
<table><tr><td>[[Image:5meodmtfreebase.png]]</td><td></table>
* Appearance: Off-white crystals (Sigma Aldrich)
* Composition: C13H18N20
* Molecular Weight: 218.298 g/mol
* Melting Point: 69-70°C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* XLogP: 1.9
* XLogP3: 1.5 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=1832&loc=ec_rcs PubChem])
* Stability: Stable under normal temperatures and pressures. Incompatible with strong oxidizing agents, strong acids ([http://ch3v1.chemexper.com/cheminfo/servlet/org.dbcreator.MainServlet?sort=&query=msds._msdsID%3D11173&target=msds&action=PowerSearch&from=0&format=ccd&searchValue=j%60qQ%40%40IVAdbfRfTJTYrRj%40Bfjb%40%40%40&history=off&realQuery=structure._structureID%3D4638142&onclick=1&selectionInfo=&searchTemplate=uniqueMol.structureString%3D%3F+elsor+uniqueMol.structureID%3D%3F&options=brandqtyoffer Source])
* Solubility:
Soluble in: (at least) 20mg/ml 96% ethanol ([https://www.dmt-nexus.com/forum/default.aspx?g=posts&m=176401#post176401 Source])
Practically Insoluble in water ([http://ch3v1.chemexper.com/cheminfo/servlet/org.dbcreator.MainServlet?sort=&query=msds._msdsID%3D11173&target=msds&action=PowerSearch&from=0&format=ccd&searchValue=j%60qQ%40%40IVAdbfRfTJTYrRj%40Bfjb%40%40%40&history=off&realQuery=structure._structureID%3D4638142&onclick=1&selectionInfo=&searchTemplate=uniqueMol.structureString%3D%3F+elsor+uniqueMol.structureID%3D%3F&options=brandqtyoffer Source])

==== 5-MeO-DMT Hydrochloride====
* Melting Point: 145-146°C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])

=== Bufotenine ===
5-HO-DMT - 5-hydroxy-N,N-dimethyl-tryptamine

==== Freebase Bufotenine ====
<table><tr><td>[[Image:bufoteninefreebase.png]]</td><td></table>
* CAS Registry Number: 487-93-4
* Composition: C12H16N2O
* Molecular Weight: 204.268 g/mol
* Melting point:146–147 °C (295–297 °F)
* Boiling point: 320 °C (608 °F)
* XLogP: 1.6
* XLogP3: 1.2 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* pKa:
* Solubility:
Acetone @ 20 C: soluble (5 g/100 ml)

Chloroform @ 20 C: soluble

Dichloromethane @ 20 C: soluble

Dimethyl sulfoxide (DMSO) @ 20 C: soluble (6 g/100 ml)

D-Limonene (Orange Oil) @ 20 C: insoluble

D-Limonene (Orange Oil) @ 176 C: soluble (more than 1.7 g/100 ml)

Dilute Acids and Alkalis: Soluble ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

Ethanol @ 20 C: soluble

Ether @ 20 C: soluble

Ethyl acetate @ 20 C: soluble

Heptane @ 20 C: insoluble

Heptane with 40% MEK @ 20 C: soluble (0.53 g/100 ml)

Heptane with 50% MEK @ 20 C: soluble (1.22 g/100 ml)

IPA @ 20 C: soluble

MEK @ 20 C: soluble

Methanol @ 20 C: soluble

Naphtha @ 20 C: insoluble

Water @ 20 C: nearly insoluble in pure water (no acid or alkali added)

Xylene @ 20 C: nearly insoluble (less than 0.03 g/100 ml)

Xylene @ 144 C: soluble (1.5 g/100 ml)

==== Bufotenine Fumarate ====
* Solubility:
Soluble in water

Insoluble in FASA (Fumaric Acid Saturated Acetone)

=== Psilocin ===
4-HO-DMT - 4-Hydroxy-N,N-dimethyl-tryptamine

==== Freebase Psilocin ====
<table><tr><td>[[Image:psilocinfreebase.png]]</td><td></table>
* CAS Registry Number: 520-53-6
* Composition: C12H16N2O
* Molecular Weight: 204.27 g/mol
* Melting Point: 103-104°C ([http://isomerdesign.com/PiHKAL/read.php?domain=tk&id=18 TIHKAL]) , 173-176°C (Merck Index)
* XLogP3: 2.1 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* Stability/Degradation: Unstable in solution, especially alkaline solution (Merck Index).
* Solubility:
Very slightly sol in water ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

=== Psilocybin ===
4-PO-DMT - O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine

==== Psilocybin (Psilocin Phosphate Ester) ====
<table><tr><td>[[Image:psilocybin.png]]</td><td></table>
* CAS Registry Number: 520-52-5
* Composition: C12H17N2O4P
* Molecular Weight: 284.248141 g/mol
* Melting Point: 220-228° from boiling water; 185-195° from boiling methanol ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* XLogP3: -1.6 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10624&loc=ec_rcs PubChem])
* Stability/Degradation: Dephosphorylated into Psilocin under acidic conditions. Also when ingested, by phosphatases enzymes.
* Solubility:
Soluble in water. Soluble in 20 parts boiling water (= 0.79g/ml in boiling water), 120 parts boiling methanol (= 0.0932g/ml in boiling methanol); difficultly soluble in ethanol. Practically insoluble in chloroform, benzene ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

=== Mescaline ===
3,4,5-trimethoxyphenethylamine

==== Freebase Mescaline ====
<table><tr><td>[[Image:mescalinefreebase.png]]</td><td></table>
* CAS Registry Number: 54-04-6
* Composition: C11H17NO3
* Melting point: 35-36°C (Kindler and Peschke, 103. [http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Boiling point: 180°C (12 mmHg)
* XLogP: 0.6 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* XLogP3: 0.7 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4076&loc=ec_rcs PubChem])
* pKa: 9.56
* Appearance: long needle shaped white crystals
* Molecular weight: 211.26
Notes: forms mescaline carbonate on prolonged exposure to air
* Average dose: 300 to 600 milligrams with a duration of 5 to 12 hours.
* Solubility
Soluble in: alcohol, chloroform, benzene, xylene, toluene, acetone, dichloromethane, highly soluble in isopropyl alcohol, soluble in d-limonene

Moderately soluble in: water

Insoluble in: practically insoluble in ether or petroleum ether
* LD50: i.p. rats 370 mg/kg

==== Mescaline Citrate ====
* Solubility
Soluble in water

Insoluble in: xylene, acetone <nowiki>*</nowiki>

<nowiki>*</nowiki> Possible unreliable web source.

==== Mescaline Hydrochloride ====
<table><tr><td>[[Image:mescalinehcl.png]]</td><td></table>
* Molecular weight: 247.72 (Sigma Aldrich)
* Empirical Formula (Hill Notation): C11H17NO3 • HCl (Sigma Aldrich)
* CAS Number: 832-92-8
* Appearance: colorless crystals, needles
* Melting point: 184°C ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Solubility:
Moderately soluble in: water, alcohol ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index]), methanol (at least 1.0 mg/ml, source Sigma Aldrich solution)
(Merck Index)
Insoluble in: practically insoluble in toluene and acetone, insoluble in isopropyl alcohol, diethyl ether, and d-limonene
* LD50: i.p. rats 132 mg/kg
* Storage temperature: 2-8°C (Sigma Aldrich)
* Isolation: when mescaline hydrochloride is extracted from San Pedro, Achuma, or Peruvian torch, it can be isolated from the other alkaloids by washing it in IPA or acetone (use 10 ml per gram of alkaloids, and wash 2-3 times). The non-mescaline alkaloids dissolve in the IPA or acetate, while the mescaline hydrochloride does not. Note that for the cleanest results use about 2 washes of acetone, and then 2 washes with IPA.

==== Mescaline Picrate ====
* Melting point: mp 222°C.

==== Mescaline Sulfate Dihydrate====
<table><tr><td>[[Image:mescalinesulfate.png]]</td><td></table>
* Composition: (C11H17NO3)2 • H2SO4 • 2H2O
* Appearance: prisms
* Melting point: 183–186 °C (361–367 °F)
* Molecular Weight: 309.33606
* Soluble in: hot water, methanol
* Almost insoluble in: near freezing water, alcohol, acetone <nowiki>*</nowiki>
<nowiki>*</nowiki> Possible unreliable web source.

==== Mescaline Fumarate ====
* Composition: unknown (it may be a one to one salt or may not be)
* Appearance: unknown
* Melting point: unknown
* Solubility
Soluble in: water<nowiki>**</nowiki>, acetone<nowiki>**</nowiki>

Insoluble in: unknown
<nowiki>**</nowiki> This information is from various SWIMs on this forum.

==== Mescaline Acetate ====
* Composition: unknown
* Appearance: white free flowing powder with a slight waxy texture <nowiki>***</nowiki>
* Melting point: unknown
* Solubility:
Soluble in: water<nowiki>***</nowiki>, isopropyl alcohol<nowiki>***</nowiki>, acetone<nowiki>***</nowiki>, DMSO<nowiki>***</nowiki> (more than 5 grams/100 ml), boiling MEK***

Insoluble in: xylene, d-limonene, cold MEK (Methyl Ethyl Ketone) <nowiki>***</nowiki>

<nowiki>***</nowiki> This information was validated by SWIM and is reliable.
* Isolation: when mescaline acetate is extracted from San Pedro, Achuma, or Peruvian torch, it can be isolated from the other alkaloids by washing it in cold MEK (use 10 ml per gram of alkaloids, and wash 2-3 times). The non-mescaline alkaloids dissolve in the MEK, while the mescaline acetate does not. Mescaline acetate can be recrystallized in MEK by boiling the MEK and then freezing it overnight.

=== Ibogaine ===
12-methoxyibogamine

==== Freebase Ibogaine ====
<table><tr><td>[[Image:ibogainefreebase.png]]</td><td></table>
* CAS Registry Number: 83-74-9
* Composition: C20H26N2O
* Molecular Weight: 310.43324 g/mol
* Melting Point: 152-153 °C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* XLogP3: 3.9 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* pKa: 8.1 in 80% methylcellosolve ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Solubility: Soluble in limonene ([http://www.anoniem.org/?https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=10651 Non-Toxic Iboga Extraction]) soluble in acetone

==== Ibogaine Hydrochloride ====
* Melting Point: 299-300 °C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* Solubility: Soluble in water, methanol (Sigma Aldrich), insoluble in acetone

=== Voacangine ===
12-methoxyibogamine-18-carboxylic acid methyl ester

==== Voacangine ====
<table><tr><td>[[Image:voacangine.png]]</td><td></table>
* Composition: C22H28N2O3
* Molecular Weight: 368.46932 g/mole
* Melting Point: 136–137 °C ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* pKa: 7.4 (40% aq methanol); 5.73 (33% DMF) ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* XLogP3-AA: 3.5 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])

=== LSA (ergine) ===
Lysergamide

==== Freebase LSA ====
<table><tr><td>[[Image:lsafreebase.png]]</td><td></table>
CAS Registry Number: 478-94-4
* Composition: C16H17N3O
* Molecular Weight: 267.32568 g/mol
* XLogP3: 1.6 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=442072&loc=ec_rcs PubChem])

=== Muscimol ===
Pantherine, Agarine

==== Freebase Muscimol ====
<table><tr><td>[[Image:muscimolfreebase.png]]</td><td></table>
* Appearance: White powder (Sigma Aldrich)
* CAS Registry Number: 2763-96-4
* Composition: C4H6N2O2
* Molecular Weight: 114.10264 g/mol
* Melting Point: 175°C (Merck Index)
* XLogP3-AA: -1.4 ([http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4266&loc=ec_rcs PubChem])

=== Salvinorin A ===
Note: Technically NOT an alkaloid, as it contains no nitrogen. It is a trans-neoclerodane diterpene.

==== Salvinorin A ====
<table><tr><td>[[Image:salvinorina.png]]</td><td></table>
* Composition: C23H28O8
* Molecular Weight: 432.46362 g/mol
* Melting Point:242-244 – 238-240 °C (Wikipedia)
* Boiling Pont: 760.2 °C (1400 °F) (Wikipedia)
* XLogP3-AA: 2.5 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])

=== Elemicin ===
1,2,3-trimethoxy-5-allylbenzene

Note: Technically NOT an alkaloid, as it contains no nitrogen.

==== Elemicin ====
<table><tr><td>[[Image:elemicin.png]]</td><td></table>

* CAS Number: 487-11-6
* Molecular Formula: C12H16O3
* Molecular Weight: 208.25364 g/mol
* Boiling Point: 152-156 °C @ 17 mmHg, 144-147 °C @ 10 mmHg ([http://www.thegoodscentscompany.com/data/rw1021681.html Source]), 146-147 °C ([http://www.chemyq.com/En/xz/xz3/20815lmxvj.htm Source 1] [http://www.chunyuan.com.cn/zhanshishow.asp?id=94 Source 2]), 279.8 °C @ 760 mmHg ([http://www.chemspider.com/Chemical-Structure.9830.html ChemSpider])
* XlogP3: 2.5 ([http://pubchem.ncbi.nlm.nih.gov/ PubChem])
* Solubility:
Soluble in alcohol, Insoluble in water ([http://www.thegoodscentscompany.com/data/rw1021681.html Source])

=== Harmine ===
7-methoxy-β-carboline

==== Freebase Harmine ====
<table><tr><td>[[Image:harminefreebase.png]]</td><td></table>
* Composition: C13H12N2O
* Molecular Weight: 212.25 (Sigma Aldrich)
* Melting point: 262-264 °C (Sigma Aldrich)
* Boiling point:
* XLogP: 2.5
* XLogP3: 3.6
* pKa: 7.7
* Solubility:
Insoluble in basic water, poorly soluble in distilled water
* Isolation: To separate from harmaline, using pKa properties, raise pH of solution containing both alkaloids to pH 8.75 to precipitate 92% of harmine and only 8% Harmaline. Filter to retrieve precipitated alkaloids, and raise the pH further to retrieve the bulk of harmaline. Check the [https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=5725 freebase percentage calculator thread] and the [http://wiki.dmt-nexus.com/Harmalas_Extraction_and_Separation_Guide Harmala Extraction Guide] for more info.

==== Harmine Hydrochloride ====
<table><tr><td>[[Image:harminehcl.png]]</td><td></table>
* Melting Point: 321 °C
* Solubility:
Soluble in water

Insoluble in salt-saturated water

=== Harmaline ===
3,4-dihydro-7-methoxy-1-methyl-β-carboline

==== Freebase Harmaline ====
<table><tr><td>[[Image:harmaline.png]]</td><td></table>
* Composition: C13H14N2O
* Melting point: 232-234 °C (Sigma Aldrich)
* Boiling point: 120-140 °C at 0.001 mm/Hg ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* XLogP: 0.8
* XLogP3: 1.2
* pKa: 9.8
* Solubility:
Slightly soluble in basic water, poorly soluble in distilled water
* Isolation: To separate from harmine, using pKa properties, raise pH of solution containing both alkaloids to pH 8.75 to precipitate 92% of harmine and only 8% Harmaline. Filter to retrieve precipitated alkaloids, and raise the pH further to retrieve the bulk of harmaline. Check the [https://www.dmt-nexus.com/forum/default.aspx?g=posts&t=5725 freebase percentage calculator thread] and the [http://wiki.dmt-nexus.com/Harmalas_Extraction_and_Separation_Guide Harmala Extraction Guide] for more info.

==== Harmaline Hydrochloride ====
* Solubility:
Soluble in water

Insoluble in salt-saturated water

=== THH ===
Tetrahydroharmine - 7-methoxy-1-methyl-1,2,3,4-tetrahydro-β-carboline

==== Freebase THH ====
<table><tr><td>[[Image:thhfreebase.png]]</td><td></table>
* Composition: C13H16N2O
* Molecular Weight: 216.27894 g/mol
* Melting Point: 187-190 °C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])
* XlogP: 1.9
* XLogP3: 1.9

Solubility: poorly soluble in distilled water

==== THH Hydrochloride ====
<table><tr><td>[[Image:thhhcl.png]]</td><td></table>
* Composition: C13H17ClN2O
* Molecular Weight: 252.73988 g/mol
* Melting Point: 232–234 °C ([http://isomerdesign.com/PiHKAL/browse.php?domain=tk TIHKAL])

== Relevant NOT psychedelic compounds ==

=== Gramine ===
N,N-Dimethyl-1H-indole-3-methanamine

==== Freebase Gramine ====
<table><tr><td>[[Image:graminefreebase.png]]</td><td></table>
* Composition: C11H14N2
* Molecular Weight: 174.24226 g/mol
* Melting point: 138-139°C (Merck)
* Boiling point:
* XLogP3: 1.8
* pKa:
* Solubility:
Sol in alcohol, ether, chloroform; slightly sol in cold acetone. Practically insol in petr ether, water. (Merck Index)

=== Hordenine ===
N,N-dimethyltyramine

==== Freebase Hordenine ====
<table><tr><td>[[Image:hordeninefreebase.png]]</td><td></table>
* CAS Registry Number: 539-15-1
* Composition: C10H15NO
* Molecular Weight: 165.23 g/mol
* Melting point: 117-118° ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Boiling point: 173° @ 11mmHg ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* XlogP3: 2.1 (PubChem)
* Solubility:
Very sol in alcohol, chloroform, ether. 7 grams dissolve in 1000 ml water. Sparingly sol in benzene, toluene, xylene. Practically insol in petr ether. ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

==== Hordenine Hydrochloride ====
<table><tr><td>[[Image:hordeninehcl.png]]</td><td></table>
* CAS Registry Number: 6027-23-2
* Composition: C10H15NO.HCl
* Molecular Weight: 201.70 g/mol
* Melting point: 177° ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])
* Solubility:
Very sol in water. ([http://wiki.dmt-nexus.com/w/images/8/81/MERCK.pdf Merck Index])

== Solvents and Alkaloids XlogP and XlogP3 ==

'''Alkaloid XlogP list'''

* 0.1 - 6-methoxy-2-methyl-beta-Carboline
* 0.7 - Beta-carboline, 6-methoxy-1,2-dimethyl-1,2-Dimethyl-2H-beta-carbolin-6-yl methyl ether
* 0.7 - Mescaline
* 0.8 - Harmaline
* 1.0 - 5-HO-Tryptamine (serotonin)
* 1.3 - 5-HO-DMT N-oxide (Bufotenine N-oxide)
* 1.6 - 5-HO-DMT (bufotenine)
* 1.7 - N-Methylserotonin
* 1.7 - DMT N-oxide (Dimethyltryptamine N-oxide)
* 1.7 - 5-MeO-NMT (5-Methoxy-N-methyltryptamine)
* 1.7 - 2-Methyl-1,2,3,4-tetrahydro-beta-carboline
* 1.8 - NMT (N-Methyltryptamine)
* 1.9 - 5-MeO-DMT (methoxybufotenin)
* 1.9 - Tetra−Hydro−Harmine (THH)
* 2.0 - DMT (Dimethyltryptamine)
* 2.5 - Harmine

'''Alkaloid XlogP3 list'''

* -1.4 - Muscimol
* -1.6 - Psilocybin
* 0.6 - Harmalol
* 0.7 - Mescaline
* 1.2 - Harmaline
* 1.2 - Bufotenine
* 1.5 - 5-MeO-DMT
* 1.6 - LSA (ergine)
* 1.8 - Gramine
* 1.9 - Tetrahydroharmine
* 2.0 - DMT N-oxide
* 2.1 - Psilocin
* 2.5 - DMT
* 2.5 - Salvinorin A
* 2.5 - Elemicin
* 3.5 - Voacangine
* 3.6 - Harmine
* 3.6 - Harman
* 3.9 - Ibogaine

Lower XlogP values are more water soluble, and higher XlogP values are more non-polar soluble.

'''Solvent XlogP list'''

* -0.7 - DMSO
* -0.5 - Methanol
* -0.1 - Ethyl Alcohol
* 0.2 - Acetone
* 0.4 - IPA
* 0.4 - MEK (Methyl Ethyl Ketone)
* 0.7 - Ethyl Acetate
* 0.9 - Ethyl Ether
* 1.5 - DCM
* 2.1 - Chloroform
* 2.5 - Toluene
* 2.5 - Xylene
* 3.7 - Limonene
* 4.3 - Heptane (similar to naphtha)