1P-LSD

2015-02-24T06:23:25Z

GameComplete:

{{Safety_profile
|
* Psychedelic
|
* Open and closed eye visuals, euphoria, change in perception of time
|
* Nausea, vasoconstriction (mostly when combined with other vasoconstricting substances like LSD), unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing
|
* Mental: paranoia, fear, and panic. No other known specific physical risks at this time (but likely similar to LSD).
|
* 1P-LSD is a substance with very little published about, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known.
* Elaborate studies on this substance have not been performed, so long term effects are UNKNOWN!
}}

[[Image:1P-LSD.png|right|thumb|200px]]

== Brief overview - What is 1P-LSD? ==

== Chemical and physical properties ==

Sharing a strong structural similarity with [[ALD-52]], the chemical purportedly used in the 1960's Orange Sunshine 1P-LSD follows the less common path of modifying the 1- position on the LSD molecule which in the past has been avoided due to unpredictable results or lack of activity.<ref>http://chemistry.mdma.ch/hiveboard/palladium/pdf/Ergot%20-%20The%20Genus%20Claviceps%20(1999)/TF3168ch8.pdf</ref>
Lots of debate is surrounding the action of 1P-LSD and is unclear exactly how the chemical is functional with an unconfirmed quote from [[David E. Nichols]] believing the chemical should be inactive while most other speculation believing it would simply follow the same metabolic path as ALD-52 and undergo conversion in vivo to LSD.

"I am sure that the 1-[[propionyl]] would also hydrolyze off of an [[indole]], but I don't know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don't know the answer to that. The compound would not be active as the N-propionyl however. Way that LSD docks into the [[5-HT2A receptor]], the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won't fit into the receptor."<ref>http://www.shroomery.org/forums/showflat.php/Number/21106929#21106929</ref>.



== Links ==
* http://www.bluelight.org/vb/threads/745848-The-Big-amp-Dandy-1P-LSD-%281-propionyl-lysergic-acid-diethylamide%29-Thread
* https://en.wikipedia.org/w/index.php?title=Draft:1P-LSD&oldid=647406505
* https://www.reddit.com/r/Drugs/comments/2s615k/new_novel_lysergamide_1plsd/

== References ==
<references />
{{Page Footer|Allies and Associated Alkaloids}}
[[Category:Alkaloids]]

1P-LSD

2015-02-24T06:19:53Z

GameComplete: /* Chemical and physical properties */

{{Safety_profile
|
* Psychedelic
|
* Open and closed eye visuals, euphoria, change in perception of time
|
* Nausea, vasoconstriction (mostly when combined with other vasoconstricting substances like LSD), unusual body sensations (facial flushing, chills, goosebumps, body energy), slight increase in heart rate, difficulty focusing
|
* Mental: paranoia, fear, and panic. No other known specific physical risks at this time (but likely similar to LSD).
|
* 1P-LSD is a substance with very little published about, with little known about its pharmacological or behavioral risks. The LD50 (median lethal dose) is not known.
* Elaborate studies on this substance have not been performed, so long term effects are UNKNOWN!
}}

[[Image:1P-LSD.png|right|thumb|200px]]

== Brief overview - What is 1P-LSD? ==

== Chemical and physical properties ==

Sharing a strong structural similarity with [[ALD-52]], the chemical purportedly used in the 1960's Orange Sunshine 1P-LSD follows the less common path of modifying the 1- position on the LSD molecule which in the past has been avoided due to unpredictable results or lack of activity.<ref>http://chemistry.mdma.ch/hiveboard/palladium/pdf/Ergot%20-%20The%20Genus%20Claviceps%20(1999)/TF3168ch8.pdf</ref>
Lots of debate is surrounding the action of 1P-LSD and is unclear exactly how the chemical is functional with an unconfirmed quote from [[David E. Nichols]] believing the chemical should be inactive while most other speculation believing it would simply follow the same metabolic path as ALD-52 and undergo conversion in vivo to LSD.

"I am sure that the 1-[[propionyl]] would also hydrolyze off of an [[indole]], but I don't know whether in vivo conditions would work. In a chemistry lab, you can get off an N-benzoyl, so an N-propionyl will probably come off too. But in the body? I don't know the answer to that. The compound would not be active as the N-propionyl however. Way that LSD docks into the [[5-HT2A receptor]], the indole NH hydrogen bonds to serine 5.46. With the propionyl, it won't fit into the receptor."<ref>http://www.shroomery.org/forums/showflat.php/Number/21106929#21106929</ref>.

== Effects ==

== Pharmacology, toxicity and general safety ==

== Dosages and consumption methods ==

== History of usage ==

== Analysis of 1P-LSD ==

== Scientific publications ==

== Other links of interest ==

{{Page Footer|Allies and Associated Alkaloids}}
[[Category:Alkaloids]]

1P-LSD

2015-02-24T06:16:54Z

GameComplete: Created page with "{{Safety_profile | * Psychedelic | * Open and closed eye visuals, euphoria, change in perception of time | * Nausea, vasoconstriction (mostly when combined with other vasocons..."